Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis regulatory elements

Autor: A. G. Anderson, B. B. Rogers, J. M. Loupe, I. Rodriguez-Nunez, S. C. Roberts, L. M. White, J. N. Brazell, W. E. Bunney, B. G. Bunney, S. J. Watson, J. N. Cochran, R. M. Myers, L. F. Rizzardi

SummaryCell type-specific transcriptional differences between brain tissues from donors with Alzheimer’s disease (AD) and unaffected controls have been well-documented, but few studies have rigorously interrogated the regulatory mechanisms responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ee6edac6231fa30fb46ef634329b43f
https://doi.org/10.1101/2022.10.04.510636

PSF reconstruction validated using on-sky CANARY data in MOAO mode

Autor: O. Martin, Eric Gendron, Alastair Basden, Gérard Rousset, Damien Gratadour, Fabrice Vidal, R. M. Myers, Carlos Correia, Thierry Fusco, Tim Morris, Benoit Neichel

Publikováno v: Proceedings of the SPIE
Adaptive Optics Systems V
Adaptive Optics Systems V, Jun 2016, Edinburgh, United Kingdom. pp.99091Q 1-13, ⟨10.1117/12.2231424⟩

International audience; CANARY is an open-loop tomographic adaptive optics (AO) demonstrator that was designed for use at the 4.2m William Herschel Telescope (WHT) in La Palma. Gearing up to extensive statistical studies of high redshifted galaxies s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272ffbdb2d47b1a7e97fd5afdb1382a8
https://doi.org/10.1117/12.2231424

Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease

Autor: R A, Popat, S K, Van Den Eeden, C M, Tanner, F, Kamel, D M, Umbach, K, Marder, R, Mayeux, B, Ritz, G W, Ross, H, Petrovitch, B, Topol, V, McGuire, S, Costello, A D, Manthripragada, A, Southwick, R M, Myers, L M, Nelson

Publikováno v: European journal of neurology. 18(5)

In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson's disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A). Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2). Our objective wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c09b04b512fbbd74a672f4575e08935
https://pubmed.ncbi.nlm.nih.gov/21834891

Performance of Monte-Carlo simulation of adaptive optics systems of the EAGLE multi-IFU instrument for E-ELT

Autor: Tim Morris, R. M. Myers, Timothy Butterley, Mark A. Harrison, Benoit Neichel, Richard Wilson, Alastair Basden, Brice Le Roux, Thierry Fusco, Eddy Younger

Publikováno v: Proceedings of the SPIE
Adaptive Optics Systems
Adaptive Optics Systems, Jun 2008, Marseille, France. ⟨10.1117/12.789276⟩

International audience; A method that has been followed to produce performance estimates for the adaptive optics (AO) aspect of the EAGLE instrument proposed for the European Extremely Large Telescope (ELT) (E-ELT) using Durham Monte-Carlo simulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a1b204ffc0e8178bd939206d0b948
https://doi.org/10.1117/12.789276

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein

Autor: M H Brodsky, M Warton, R M Myers, D R Littman

Publikováno v: The Journal of Immunology. 144:3078-3086

The first step in infection of human mononuclear cells with HIV involves the high affinity binding of the viral envelope glycoprotein, gp120, to the cell-surface receptor, CD4. To gain a better understanding of the molecular basis of this interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3da38866127f39d2251a433a87ff4074
https://doi.org/10.4049/jimmunol.144.8.3078