Zobrazeno 1 - 10
of 85
pro vyhledávání: '"R. M. Mcclain"'
Autor:
R M McClain
Publikováno v:
Toxicology Letters. :397-408
There are two basic mechanisms whereby chemicals produce thyroid gland neoplasia in rodents. The first involves chemicals that exert a direct carcinogenic effect in the thyroid gland and the other involves chemicals which, through a variety of mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fe1f308964a49220d587de70919bed
https://doi.org/10.1016/0378-4274(92)90213-4
https://doi.org/10.1016/0378-4274(92)90213-4
Autor:
James L Ivett, B Jessen, Bhasker Shetty, C C Capen, T E Ryan, R Gasser, Gregory J. Stevens, J C Theiss, Leigh Ann Burns-Naas, R M McClain, G Furman, W Evering, Mark Zorbas, E Wu, J C Cook, Stephanie Webber, M Chen
Publikováno v:
Humanexperimental toxicology. 24(12)
The carcinogenic potential of nelfinavir mesylate (nelfinavir) was evaluated in a 2-year oral (gavage) study on Sprague-Dawley rats at dose levels of 0 (control), 0 (vehicle control), 100, 300 and 1000 mg/kg per day. At the end of the treatment, incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26c16a3607fe5464da333fc5d34f14b
https://pubmed.ncbi.nlm.nih.gov/16408618
https://pubmed.ncbi.nlm.nih.gov/16408618
Autor:
R M, McClain, J M, Rice
Publikováno v:
IARC scientific publications. (147)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::559a1d33853e8b5bdf71a840df542bfa
https://pubmed.ncbi.nlm.nih.gov/10457910
https://pubmed.ncbi.nlm.nih.gov/10457910
Publikováno v:
International journal of cancer. 72(3)
Modifications to DNA-5-methylcytosine (5MeC) content (i.e., alterations in the level of 5MeC) constitute epigenetic events. In general, hypomethylation of a gene is necessary but not sufficient for expression, while methylated genes typically are qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3191cf29f45c225acb14ed4fdfbbe7f5
https://pubmed.ncbi.nlm.nih.gov/9247294
https://pubmed.ncbi.nlm.nih.gov/9247294
Publikováno v:
Molecular carcinogenesis. 18(2)
The effects of different liver tumor-promoting treatments (i.e., a choline-devoid, methionine-deficient (CMD) diet, phenobarbital (PB), or both) on Ha-ras and raf methylation status and expression were determined in mouse strains with different susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::505119f08599bb141e3d2abbd043e245
https://pubmed.ncbi.nlm.nih.gov/9049185
https://pubmed.ncbi.nlm.nih.gov/9049185
Autor:
R. M. Mcclain
Publikováno v:
Mutation research. 333(1-2)
There are two basic mechanisms whereby chemicals produce thyroid gland neoplasia in rodents. The first involves chemicals that exert a direct carcinogenic effect in the thyroid gland and the other involves chemicals which, through a variety of mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad436bc51fb49f3a9abe6214a945d324
https://pubmed.ncbi.nlm.nih.gov/8538620
https://pubmed.ncbi.nlm.nih.gov/8538620
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment
Autor:
R M, McClain
Publikováno v:
Progress in clinical and biological research. 391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad8b5ac444928809afdf526928019fb4
https://pubmed.ncbi.nlm.nih.gov/8532725
https://pubmed.ncbi.nlm.nih.gov/8532725
Autor:
R W, Nims, R M, McClain, P S, Manchand, P S, Belica, P E, Thomas, D W, Mellini, W E, Utermahlen, R A, Lubet
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
To explore further the structural requirements for ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of CYP2B induction by 5,5-diphenylbarbituric acid, phenytoin (5,5-diphenylhydantoin), barbital (5,5-diethylbarbituric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d899bcf72b129ec352ca7ed5f8787303
https://pubmed.ncbi.nlm.nih.gov/8035330
https://pubmed.ncbi.nlm.nih.gov/8035330
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 65(3)
The adrenal medulla is innervated by nerve fibers from several sources, which synapse on chromaffin cells and stimulate the secretion of catecholamines. The antihypertensive agent reserpine is known to reflexively increase this neurogenic stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49a79c8ba3771535df28a2526bb1d023
https://pubmed.ncbi.nlm.nih.gov/1890815
https://pubmed.ncbi.nlm.nih.gov/1890815