Zobrazeno 1 - 10
of 35
pro vyhledávání: '"R. M. Liskay"'
Publikováno v:
Oncogene
APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. Therefore, we measured transfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01690dcfabb6dcc2bc2d1e2ecc08c945
http://europepmc.org/articles/PMC3235266
http://europepmc.org/articles/PMC3235266
Publikováno v:
Proceedings of the National Academy of Sciences. 98:9760-9765
Previously, we reported evidence suggesting that Saccharomyces cerevisiae MutLα, composed of Mlh1p and Pms1p, was a functional member of the gyrase b/Hsp90/MutL (GHL) dimeric ATPase superfamily characterized by highly conserved ATPase domains. Simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25046e0dbec4899145601bbce4f800b8
https://doi.org/10.1073/pnas.161175998
https://doi.org/10.1073/pnas.161175998
Publikováno v:
Proceedings of the National Academy of Sciences. 91:12554-12558
We have derived Chinese hamster ovary (CHO) cell hybrids containing herpes simplex virus thymidine kinase (tk) heteroalleles for the study of spontaneous and restriction enzyme-induced interchromosomal recombination. These lines allowed us to make a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa89f74096430b09d3d4de98772d541f
https://doi.org/10.1073/pnas.91.26.12554
https://doi.org/10.1073/pnas.91.26.12554
Publikováno v:
Molecular and Cellular Biology. 14:407-415
We have identified a new Saccharomyces cerevisiae gene, MLH1 (mutL homolog), that encodes a predicted protein product with sequence similarity to DNA mismatch repair proteins of bacteria (MutL and HexB) and S. cerevisiae yeast (PMS1). Disruption of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c487959dbb039c44a08e9a95a3de7ee9
https://doi.org/10.1128/mcb.14.1.407
https://doi.org/10.1128/mcb.14.1.407
Publikováno v:
Molecular and Cellular Biology. 12:1546-1552
We have studied intrachromosomal gene conversion in mouse Ltk- cells with a substrate designed to provide genetic evidence for heteroduplex DNA. Our recombination substrate consists of two defective chicken thymidine kinase genes arranged so as to fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a15f85f4d616d01d253e4c8dcf8cd4
https://doi.org/10.1128/mcb.12.4.1546
https://doi.org/10.1128/mcb.12.4.1546
Autor:
R J Bollag, R M Liskay
Publikováno v:
Molecular and Cellular Biology. 11:4839-4845
Homologous intrachromosomal recombination between linked genes can involve interactions that are either intramolecular (intrachromatid) or intermolecular (sister chromatid). To assess the relative proportions of chromatid interactions, we report stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02565cc5504bb7e9293452ba7f081687
https://doi.org/10.1128/mcb.11.10.4839-4845.1991
https://doi.org/10.1128/mcb.11.10.4839-4845.1991
Autor:
Nicolé M. Hedrick, R M Liskay, E Winkeler, S Dudley, Omar Kabbarah, David H. Gutmann, Paul J. Goodfellow
Publikováno v:
Oncogene. 22(29)
Defects in DNA mismatch repair (MMR) have been implicated in the genesis of a diverse set of human cancers. Recent studies have suggested that one of the targets of MMR is the neurofibromatosis 1 (NF1) gene. To evaluate the contribution of Mlh1 MMR d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18484af3cbfe511e65f87a969801ccca
https://pubmed.ncbi.nlm.nih.gov/12881715
https://pubmed.ncbi.nlm.nih.gov/12881715
Publikováno v:
The Journal of heredity. 93(3)
Meiotic recombination was studied in DNA mismatch repair (MMR)-deficient mice using a strain carrying a Pms2 knockout mutation. Using single-sperm typing, recombination was analyzed over five intervals on four chromosomes in four Pms2 -/- animals. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc3c55935756fdbc45e2bdc5a5bb47c
https://pubmed.ncbi.nlm.nih.gov/12195036
https://pubmed.ncbi.nlm.nih.gov/12195036
Publikováno v:
Cancer research. 61(9)
DNA mismatch repair (MMR) has been shown to play a role in the cytotoxicity of ionizing radiation (IR), as cell lines established from MMR-deficient mice exhibit higher clonogenic survival after IR than do cell lines from wild-type littermates. To te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9cf70eb894a502d57de229033779abd
https://pubmed.ncbi.nlm.nih.gov/11325851
https://pubmed.ncbi.nlm.nih.gov/11325851
Publikováno v:
Cancer research. 60(17)
The cytotoxicity of ionizing radiation (IR) has been associated with both the p53 pathway and with DNA mismatch repair (MMR). p53 mediates cell cycle arrest and apoptosis in response to X-ray damage, whereas the MMR complex is thought to recognize da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::135d03a7cf69bb7a81cddd7303b5bad2
https://pubmed.ncbi.nlm.nih.gov/10987303
https://pubmed.ncbi.nlm.nih.gov/10987303