Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R. M. J. Ings"'
Publikováno v:
The Handbook of Medicinal Chemistry ISBN: 9781788018982
It is almost impossible to design a bioavailable, long half-life and safe drug without a good understanding of both the principles of, and specific risks associated with, drug metabolism. Designing potent compounds with limited metabolic liabilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf89d608ac5f46d4a55309b9be1ab2d1
https://doi.org/10.1039/9781788018982-00265
https://doi.org/10.1039/9781788018982-00265
Autor:
R. M. J. Ings
Publikováno v:
Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c177fa14c3c4c1a777be8af030984b
https://doi.org/10.1201/9780367813093-8
https://doi.org/10.1201/9780367813093-8
Autor:
C. W. Vose, R. M. J. Ings
Drug metabolism is the chemical alteration of a drug via a biological system to aid its elimination by increasing its hydrophilicity. Drug metabolism occurs in two phases: Phase 1 includes oxidative reactions such as those undertaken by the cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e868bd878bb3334b35cc1848c76ccc7b
https://doi.org/10.1039/9781782621836-00184
https://doi.org/10.1039/9781782621836-00184
Autor:
D. Wallace, R.D. Brownsill, A. J. Gray, R. P. Richards, A. R. Taylor, R. M. J. Ings, T. Hughes, M. P. Hiley, J. Williams, C. Lucas, D. B. Campbell, B. H. Gordon, R. Thomas, N. C. Marchant, M. Breen
Publikováno v:
European Journal of Cancer and Clinical Oncology. 26:838-842
The pharmacokinetics and metabolism of intravenously infused 14C-fotemustine (about 100 mg/m2) were examined in 2 cancer patients. Plasma levels of radioactivity increased to a maximum of 4.1 and 5.5 micrograms equivalents per g when the infusion sto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f77092529574c6fe5d32c9e6091350
https://doi.org/10.1016/0277-5379(90)90166-q
https://doi.org/10.1016/0277-5379(90)90166-q
Autor:
R M J Ings
Publikováno v:
Bioanalysis. 2:371-372
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f4ce9987d4f5ff2d8151c05071a888
https://doi.org/10.4155/bio.10.9
https://doi.org/10.4155/bio.10.9
Autor:
N. C. Marchant, R. M. J. Ings, J. Williams, D. Wallace, M. Breen, A. R. Taylor, S. Bass, D. B. Campbell
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(11)
1. The comparative metabolism of fenfluramine was investigated in mouse, rat, dog and man following a single oral dose of 14C-(+/-)-fenfluramine hydrochloride (1 mg/kg), and also in rat after eight consecutive 12-h subcutaneous doses (24 mg/kg). 2. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0517845fec805206be155ac560ed9916
https://pubmed.ncbi.nlm.nih.gov/1492418
https://pubmed.ncbi.nlm.nih.gov/1492418
Autor:
M. Clavel, P. Solere, D. Minaidis, S. Leyvraz, C. Ardiet, F. Lokiec, F. Turpin, E. Lelièvre, R. M. J. Ings, C. Lucas
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(7)
1. A novel anticancer vinca alkaloid derivative (I) has been given as an i.v. bolus to cancer patients, using four different dosage regimens with dose levels ranging from 0.04 to 0.84 mg/m2 (equivalent to between 0.12 and 1.35 mg per dose), and the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab7607cf448b6d51664b44338e74348
https://pubmed.ncbi.nlm.nih.gov/1455905
https://pubmed.ncbi.nlm.nih.gov/1455905
Autor:
R. M. J. Ings
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(11)
1. Methods of interspecies extrapolation using physiological models and allometric scaling have been reviewed with their possible application to drug development, both for candidate drug selection and the interpretation of toxicokinetic data. 2. Phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f52a0aae599845445ff756412972ae8
https://pubmed.ncbi.nlm.nih.gov/2275215
https://pubmed.ncbi.nlm.nih.gov/2275215
Autor:
F. E. Edwards, D. B. Campbell, M. Breen, A. J. Gray, M. Briggs, K. Devereux, C. Lucas, B. V. Robinson, R. M. J. Ings
Publikováno v:
Cancer chemotherapy and pharmacology. 27(2)
The distribution and excretion of radioactivity from [14C]-fotemustine was examined in mice with melanomas at different stages of development to determine whether the disease state substantially alters the disposition of the drug and its metabolites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2968b26efca5ab57c50fd3cb02712dc
https://pubmed.ncbi.nlm.nih.gov/2249325
https://pubmed.ncbi.nlm.nih.gov/2249325
Publikováno v:
Xenobiotica. 19:329-339
1. An analytical method for a novel nitrosourea, fotemustine, has been developed using solid-phase extraction and h.p.l.c. with u.v. detection. As part of the development, different methods for stabilising fotemustine after sample collection have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fccf15b7116d24495212afb40ad61aa
https://doi.org/10.3109/00498258909042277
https://doi.org/10.3109/00498258909042277