Zobrazeno 1 - 8 of 8 pro vyhledávání: '"R. M. Hillman"'
1
Degradation of growth hormone releasing factor analogs in neutral aqueous solution is related to deamidation of asparagine residues
Autor: L. F. Krabill, R. M. Hillman, A. K. Ichhpurani, H A Zurcher-Neely, Alan R. Friedman, David M. Guido, R. A. Martin, D. M. Brown
Publikováno v: International Journal of Peptide and Protein Research. 37:14-20
The incubation of a solution of the human growth hormone releasing factor analog, [Leu27] hGRF(1-32)NH2 at pH 7.4 and 37 degrees, resulted in extensive degradation of the sample. The major degradation products were identified as the peptides [beta-As
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade37036b2d65367d06b89df069c4206
https://doi.org/10.1111/j.1399-3011.1991.tb00727.x
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2
Position 2 and position 2/Ala15-substituted analogs of bovine growth hormone-releasing factor (bGRF) with enhanced metabolic stability and improved in vivo bioactivity
Autor: M. C. Goodwin, A. R. Friedman, R. M. Hillman, W. H. Claflin, A. K. Ichhpurani, G. R. Alaniz, Cleary Dl, Teresa M. Kubiak, C. R. Kelly, R. A. Martin
Publikováno v: Journal of Medicinal Chemistry. 36:888-897
In order to prepare GRF analogs with high activity in vivo, a strategy was undertaken to stabilize the peptide to dipeptidylpeptidase IV (DPP-IV), a protease found in plasma which inactivates native human and bovine GRF by cleavage of the Ala2-Asp3 b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e2bf7b1bd52854f96e27a24774ff86
https://doi.org/10.1021/jm00059a014
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3
Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression
Autor: Cecilia Hofmann, Jerry R. Colca, C W Edwards, R M Hillman
Publikováno v: Endocrinology. 130:735-740
Obese KKAy insulin-resistant mice represent a model for the human syndrome of noninsulin-dependent diabetes mellitus. As such, the animals are hyperglycemic and hyperinsulinenic. Treatment of KKAy mice with pioglitazone, a new antihyperglycemic agent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccc3ddcfbd6bb8c3d9ee0577b6b8a05
https://doi.org/10.1210/endo.130.2.1733721
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6
1H NMR analysis and in vitro bioactivity of Leu27-bGRF(1-29)NH2 and its D-Ala2 and des-(Tyr1-Ala2)-analogs
Autor: D A, Kloosterman, T A, Scahill, R M, Hillman, D L, Cleary, T M, Kubiak
Publikováno v: Peptide research. 4(2)
Relative growth hormone-releasing potencies of bovine growth hormone-releasing factor (bGRF) analogs bGRF(1-44)NH2 (I), Leu27-bGRF(1-29)NH2 (II) and D-Ala2, Leu27-bGRF(1-29)NH2 (III) in in vitro bovine anterior pituitary cell cultures were determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a119adcd988700b5da2b78e8a1416c85
https://pubmed.ncbi.nlm.nih.gov/1667740
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8
Relation of in vitro properties to tumorigenicity for a series of sublines of the human breast cancer cell line MCF-7
Autor: W B, Butler, P J, Berlinski, R M, Hillman, W H, Kelsey, M M, Toenniges
Publikováno v: Cancer research. 46(12 Pt 1)
The relation of in vitro properties to tumorigenicity was studied using eight sublines of the human breast cancer cell line MCF-7. Four of the eight were tumorigenic in estrogen-treated nude mice. The sublines differed for each of the in vitro proper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad1633b0b12bce95089d13bd80606b4c
https://pubmed.ncbi.nlm.nih.gov/3779650
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