Zobrazeno 1 - 10
of 1 386
pro vyhledávání: '"R. M. Henkelman"'
Autor:
Thomas Arbogast, Christelle Golzio, R. M. Henkelman, William C. Wetsel, Parisa Razaz, Benjamin Currall, Jacob Ellegood, Serkan Erdin, Lily R. Qiu, Ramona M. Rodriguiz, Spencer U. McKinstry, Jason P. Lerch, Michael E. Talkowski, Tanya Aneichyk, Nicholas Katsanis
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 2019, 28 (9), pp.1474-1486. ⟨10.1093/hmg/ddy436⟩
Hum Mol Genet
Human Molecular Genetics, 2019, 28 (9), pp.1474-1486. ⟨10.1093/hmg/ddy436⟩
Hum Mol Genet
The 16p11.2 BP4-BP5 deletion and duplication syndromes are associated with a complex spectrum of neurodevelopmental phenotypes that includes developmental delay and autism spectrum disorder, with a reciprocal effect on head circumference, brain struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0310455ab6cc2836c3a7eb6cc820a942
https://doi.org/10.1093/hmg/ddy436
https://doi.org/10.1093/hmg/ddy436
Autor:
R. M. Henkelman, Michael D. Sherar, W. Kucharczyk, M. J. Bronskill, A. C. Easty, B. C. Wilson, J. W. Hunt, R. S. Hinks, J. C. Chen, A. S. Gladman, Michael C. Kolios, R. D. Peters, J. A. Moriarty, I. Alex Vitkin
Changes in magnetic resonance (MR) signals during interstitial microwave heating are reported, and correlated with simultaneously acquired temperature readings from three fiber-optic probes implanted in a polyacrylamide gel phantom. The heating by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512684f639b1678ae331452d0c164330
https://doi.org/10.32920/14638608.v1
https://doi.org/10.32920/14638608.v1
Autor:
Emanuel DiCicco-Bloom, Sean E. Egan, Lucy R. Osborne, Jeremy Veenstra-VanderWeele, Armin Raznahan, Darren J. Fernandes, Jason P. Lerch, Michael W. Salter, Craig M. Powell, Ameet S. Sengar, Randy D. Blakely, Diane M. Robins, Rand Askalan, R. M. Henkelman, Jacob Ellegood
Publikováno v:
NeuroImage. 163
MRI is a powerful modality to detect neuroanatomical differences that result from mutations and treatments. Knowing which genes drive these differences is important in understanding etiology, but candidate genes are often difficult to identify. We te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71384fa79e63ad3fbce9276b4d91daa5
https://pubmed.ncbi.nlm.nih.gov/28882630
https://pubmed.ncbi.nlm.nih.gov/28882630
Autor:
Sean E. Egan, S. C. Juneja, Michael W. Salter, Ameet S. Sengar, Adelaide P. Yiu, Sheena A. Josselyn, Wei Wang, H. Wang, R. M. Henkelman, Jason P. Lerch, Jacob Ellegood
Publikováno v:
The Journal of Neuroscience. 33:4055-4065
Invertebrate studies have highlighted a role for EH and SH3 domain Intersectin (Itsn) proteins in synaptic vesicle recycling and morphology. Mammals have twoItsngenes (Itsn1andItsn2), both of which can undergo alternative splicing to include DBL/PH a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd34c5a82abf54bcd298aefe6ba6e4
https://doi.org/10.1523/jneurosci.4428-12.2013
https://doi.org/10.1523/jneurosci.4428-12.2013
Autor:
Curtis W. Boswell, Daniel T. Grimes, Brian Ciruna, Rebecca D. Burdine, Nicholas F.C. Morante, R. M. Henkelman
Altered fluid flow causes curved spine Adolescent idiopathic scoliosis is characterized by three-dimensional spinal curves and affects 3% of the world's children. However, the biological basis of this condition is unclear. Grimes et al. studied zebra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78df122041542a659e3125b85c80d08c
https://europepmc.org/articles/PMC5574193/
https://europepmc.org/articles/PMC5574193/
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H1249-H1259
The availability of detailed three-dimensional images of vascular trees from mammalian organs provides a wealth of essential data for understanding the processes and mechanisms of vascular patterning. Using this detailed geometric data requires the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3badc2bf8349a7b38c9930e4254d38f3
https://doi.org/10.1152/ajpheart.00363.2009
https://doi.org/10.1152/ajpheart.00363.2009
Autor:
Daniela Rotin, Chong Jiang, Nils Brose, Benoit G. Bruneau, R. M. Henkelman, Hiroshi Kawabe, Annie Huang, Limei Zhou, Jonathon R. Walls, Chen Lu, Yimin She, Fatemeh Fouladkou
Publikováno v:
Journal of Biological Chemistry. 285:6770-6780
Nedd4 (Nedd4-1) is a Hect domain E3 ubiquitin ligase that also contains a C2 domain and three WW domains. Despite numerous in vitro studies, its biological function in vivo is not well understood. Here we show that disruption of Nedd4-1 in mice (leav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d511936a7c494a9e3ff9d40da5b66290
https://doi.org/10.1074/jbc.m109.082347
https://doi.org/10.1074/jbc.m109.082347
Autor:
Jingyi Pan, Brendan A.S. McIntyre, R. M. Henkelman, Lisa X. Yu, Michelle Letarte, J. Leen, Jaques Belik, Mirjana Jerkic, Mourad Toporsian
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L1170-L1178
Endoglin is a TGF-β superfamily receptor critical for endothelial cell function. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia type I (HHT1), and clinical signs of disease are generally more evident later in life.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7688e2cc2cedfd84f73020e4d204eeac
https://doi.org/10.1152/ajplung.00168.2009
https://doi.org/10.1152/ajplung.00168.2009
Publikováno v:
NeuroImage. 42:60-69
Detailed anatomical atlases can provide considerable interpretive power in studies of both human and rodent neuroanatomy. Here we describe a three-dimensional atlas of the mouse brain, manually segmented into 62 structures, based on an average of 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9906c4a6fafab479fa04314152986f7
https://doi.org/10.1016/j.neuroimage.2008.03.037
https://doi.org/10.1016/j.neuroimage.2008.03.037
Publikováno v:
Magnetic Resonance in Medicine. 59:1412-1421
Inhaled molecular oxygen has been widely used in humans to evaluate pulmonary ventilation using MRI. MR imaging has recently played a greater role in examining the morphologic and physiologic characteristics of mouse models of lung disease where stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babc832f2bacdebe1a8539f7e68faa06
https://doi.org/10.1002/mrm.21517
https://doi.org/10.1002/mrm.21517