Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R. M. Gutsul"'
Publikováno v:
Chemistry of Heterocyclic Compounds. 47:309-315
The alkylation of derivatives of 3-aminoisoquinolin-1(2H)-one in the presence of NaH may proceed in three directions: 1) at the carbonyl group oxygen atom, 2) at the nitrogen atom N-2, and 3) at the 3-amino group. The reaction of equivalent amounts o
Publikováno v:
Chemistry of Heterocyclic Compounds. 47:342-354
The reaction of 3-NHR-isoquinolin-1(2H)-ones (R = Ar) with aromatic aldehydes in the presence of Me3SiCl or in acetic acid leads to the formation of derivatives of dibenzo[b,f][1, 8]naphthyridin-5(6H)- one and benzo[f]isoquino[3,4-b][1, 8]naphthyridi
Publikováno v:
Chemistry of Heterocyclic Compounds. 46:457-467
The reaction of 2-(cyanomethyl)benzoic acid with amines RNH2 (R = Ar, Het, CH2Ar, CH2Het) leads to the formation of the corresponding 3-NHR-isoquinolin-1(2H)-ones. When R = CH2Ar and CH2Het, there is a side reaction involving hydrolysis of the hydrol
Publikováno v:
Chemistry of Heterocyclic Compounds. 45:42-47
Heating 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with isonicotinoyl chloride in pyridine gives 6-isonicotinoyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one. The 1-alkyl-4[(11-oxo-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-6-yl)carbonyl]
Publikováno v:
Chemistry of Heterocyclic Compounds. 44:585-593
It was shown that 6-acyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-ones are formed when 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one is heated with the chlorides and anhydrides of carboxylic acids in the presence of bases (pyridine, NaOAc) w
Publikováno v:
Chemistry of Heterocyclic Compounds. 44:208-213
Condensation of 2-(cyanomethyl)benzoic acid with 2-aminobenzylamine gave 6,11-dihydro-13H-isoquino[3,2-b]quinazolin-11-one. Its oxidation in nitrobenzene led to the formation of 5,13,5′,13′-hexahydro[6,6′]bi[isoquino[3,2-b]quinazoline]-11,11′
Publikováno v:
Chemistry of Heterocyclic Compounds. 42:100-108
During acylation of 7-isonicotinoyl-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one or its alkylation followed by treatment with organic bases, spirocyclization occurs with formation of derivatives of a novel heterocyclic system: 1′-acyl-and 1′-a
Publikováno v:
ChemInform. 43
The reaction of 3-aminoisoquinolinone derivatives with aromatic aldehydes in the presence of Tms-Cl leads to the formation of fused naphthyridine and isoquinolinone derivatives.
Publikováno v:
ChemInform. 43
Alkylation of title compounds predominantly proceeds at the 3-amino group to give compounds (III).
Publikováno v:
ChemInform. 42
The reaction of 2-(cyanomethyl)benzoic acid (I) with hetarylamines (II) leads selectively to 3-aminoisoquinolinones (III).