Výsledky vyhledávání - "R. M. Ferris"

Autor: J. A. Salmon, R. M. Ferris, B. J. R. Whittle

Publikováno v: Early Phase Drug Evaluation in Man ISBN: 9781349107070

The pharmacological studies that must be conducted on a new chemical entity (NCE) to support the application for an CTX/IND or an MAA/NDA are not defined precisely by the regulatory authorities. Although most readers are probably familiar with the ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a478efda3106a864c079b439937fe
https://doi.org/10.1201/9780367812454-3

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Bupropion: a review of its mechanism of antidepressant activity

Autor: J A, Ascher, J O, Cole, J N, Colin, J P, Feighner, R M, Ferris, H C, Fibiger, R N, Golden, P, Martin, W Z, Potter, E, Richelson

Publikováno v: The Journal of clinical psychiatry. 56(9)

The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study. A review of the relevant biochemical, in vivo brain microdialysis, electrophysiologic, behavioral, and clinical data clarifies what is known abou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3610c29d3ffa1586c0733fb4dd8626df
https://pubmed.ncbi.nlm.nih.gov/7665537

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The effects of biliary obstruction on the rates of uptake, synthesis and secretion of14C-labeled cholesterol by isolated perfused rat livers

Autor: H. P. Jacobj, R. M. Ferris, A. J. Barak

Publikováno v: Lipids. 7:20-25

The isolated perfused rat liver technique was utilized to study the effect of biliary obstruction on the rates of uptake, synthesis and secretion of14C-labeled cholesterol in an effort to elucidate the mechanism of hypercholesterolemia in this condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8383fd6705ecfb5af2dad766f3da671
https://doi.org/10.1007/bf02531264

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Studies of bupropion's mechanism of antidepressant activity

Autor: R M, Ferris, B R, Cooper, R A, Maxwell

Publikováno v: The Journal of clinical psychiatry. 44(5 Pt 2)

The data obtained in these studies show that the antidepressant activity of bupropion cannot be explained by its ability to inhibit MAO present in brain or to increase the release of biogenic amines from nerve endings, since the drug possesses neithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2c8657978c108eaa0e2f9377a84ed1e
https://pubmed.ncbi.nlm.nih.gov/6406468

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Neurochemical and neuropharmacological investigations into the mechanisms of action of bupropion . HCl--a new atypical antidepressant agent

Autor: R M, Ferris, R A, Maxwell, B R, Cooper, F E, Soroko

Publikováno v: Advances in biochemical psychopharmacology. 31

In the present study, bupropion has been shown to be effective in several behavioral models predictive of antidepressant activity suggesting that it should be an effective antidepressant in man. Furthermore, the data also show that the antidepressant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed5195cf57871e4834ab624711e6c62c
https://pubmed.ncbi.nlm.nih.gov/6282058

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Structure-activity relationships for potent phthalane and thiophthalane inhibitors of norepinephrine uptake. A comparison with desipramine and related compounds

Autor: R A, Maxwell, R M, Ferris, E C, Woodward, F L, Tang, S B, Eckhardt

Publikováno v: Molecular pharmacology. 17(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a93da3e5b71a6c70014814ef6fae9817
https://pubmed.ncbi.nlm.nih.gov/7393212

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Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and 'GABA-mimetic' agents

Autor: B R, Cooper, K, Viik, R M, Ferris, H L, White

Publikováno v: The Journal of pharmacology and experimental therapeutics. 209(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5c689fcbac6317231220fb05975ddb4
https://pubmed.ncbi.nlm.nih.gov/220408

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The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes

Autor: R A, Maxwell, R M, Ferris, J, Burcsu, E C, Woodward, D, Tang, K, Williard

Publikováno v: The Journal of pharmacology and experimental therapeutics. 191(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63e4c44e0d5992fbd7d54151abb01bd0
https://pubmed.ncbi.nlm.nih.gov/4427288

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Bupropion: a new antidepressant drug, the mechanism of action of which is not associated with down-regulation of postsynaptic beta-adrenergic, serotonergic (5-HT2), alpha 2-adrenergic, imipramine and dopaminergic receptors in brain

Autor: O J Beaman, R M Ferris

Publikováno v: Neuropharmacology. 22(11)

The present experiments were undertaken to determine: (1) whether bupropion had any direct effects on receptors present in rat brain; (2) whether the drug could down-regulate postsynaptic beta-adrenergic, alpha 2-adrenergic, serotonergic, imipramine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95e777aa642fb8e5a2d897296b61253
https://pubmed.ncbi.nlm.nih.gov/6320035

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Pharmacology of the enantiomers of threo-methylphenidate

Autor: K S, Patrick, R W, Caldwell, R M, Ferris, G R, Breese

Publikováno v: The Journal of pharmacology and experimental therapeutics. 241(1)

The pharmacology of the enantiomers of threo-methylphenidate (MPH) was evaluated in the rat to assess the relative contribution of each isomer to central and peripheral actions of the racemic drug. Fractional recrystallization of binaphthyl phosphate

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https://pubmed.ncbi.nlm.nih.gov/3572779

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