Zobrazeno 1 - 2
of 2
pro vyhledávání: '"R. M. Exley"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Factor H binding protein (fHbp) and PorA are components of experimental serogroup B N. meningitidis vaccines. Here the authors graft the VR2 loop of PorA onto an fHBp-based scaffold to demonstrate proof-of-principle of a chimeric antigen strategy and
Externí odkaz:
https://doaj.org/article/823538b9d7624657ba20526bd2a41c1a
Publikováno v:
Nature Communications
There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use structure-based design to develop ch