Zobrazeno 1 - 10
of 21
pro vyhledávání: '"R. M. DeMarinis"'
Autor:
J P, Hieble, A C, Sulpizio, R, Edwards, H, Chapman, P, Young, S P, Roberts, T P, Blackburn, M D, Wood, D H, Shah, R M, Demarinis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
SKF 104856 (2-vinyl-7-chloro-3,4,5,6-tetrahydro-4-methyl-thieno[4,3,2ef][3] benzazepine) shows a similar selectivity profile to the previously reported alpha adrenoceptor antagonist, SKF 104078 (6-chloro-9-[(3-methyl-2-butenyl)oxy]-3-methyl-1H-2,3,4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fc45f15acb9bdb2c85b9facb23f1c79
https://pubmed.ncbi.nlm.nih.gov/1682482
https://pubmed.ncbi.nlm.nih.gov/1682482
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 19:267-270
Tritiated methoxamine with a specific activity of 28.5 Ci/mmol was prepared by iodination of methoxamine followed by catalytic tritiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7483da1c52e1d85c43a3fca937ead54
https://doi.org/10.1002/jlcr.2580190212
https://doi.org/10.1002/jlcr.2580190212
Publikováno v:
Journal of Biological Chemistry. 259:7864-7869
alpha 2-Adrenergic receptors are members of an important class of membrane-bound receptors which appear to mediate physiologic responses by decreasing the activity of the regulatory enzyme adenylate cyclase. This report describes the first direct ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b52e45220fb4692ac326b9811f9190f
https://doi.org/10.1016/s0021-9258(17)42873-0
https://doi.org/10.1016/s0021-9258(17)42873-0
Publikováno v:
Clinical and Experimental Hypertension. Part A: Theory and Practice. 9:889-912
The availability of highly selective dopamine receptor agonists has allowed the characterization of the role of DA1 and DA2 receptors in the cardiovascular system. Fenoldopam (SK&F 82526) is a potent agonist at DA1 receptors, with much less agonist a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e438ad17ea544f5e08ee718ef99a7fc8
https://doi.org/10.3109/10641968709161456
https://doi.org/10.3109/10641968709161456
Publikováno v:
Journal of Biological Chemistry. 261:3894-3900
Human platelet alpha 2-adrenergic receptors have been purified approximately 80,000-fold to apparent homogeneity by a five-step chromatographic procedure. The overall yield starting from the membranes is approximately 2%. Sodium dodecyl sulfate-polya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5283f9877ced66d2a08df081678ccc
https://doi.org/10.1016/s0021-9258(17)35731-9
https://doi.org/10.1016/s0021-9258(17)35731-9
Autor:
Robert J. Lefkowitz, J. Lafferty, R. M. DeMarinis, W. D. Matthews, A. J. Krog, D H Shah, J. P. Hieble, John W. Regan, Marc G. Caron, K. G. Holden
Publikováno v:
Journal of Medicinal Chemistry. 27:918-921
Human platelets contain alpha 2-adrenoceptors which are negatively coupled to the enzyme adenylate cyclase. In order to better understand the interaction of this subtype of alpha receptor with this key enzyme, we have initiated a program to isolate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea91d495bf5a44e85be0fb1e369b357
https://doi.org/10.1021/jm00373a018
https://doi.org/10.1021/jm00373a018
Autor:
R. M. Demarinis, J. P. Hieble
Publikováno v:
Chemischer Informationsdienst. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff40b2e5d1f0a9431300e96c255d2f9e
https://doi.org/10.1002/chin.198406149
https://doi.org/10.1002/chin.198406149
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 236(1)
SKF 86466 (6-chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine) is a potent and selective antagonist at alpha-2 adrenoceptors. Prejunctional alpha-2 adrenoceptor antagonism can be demonstrated either by blockade of the alpha-2 adrenoceptor-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31ff5d52b8257b4801bc2aea707ade93
https://pubmed.ncbi.nlm.nih.gov/2867217
https://pubmed.ncbi.nlm.nih.gov/2867217
Autor:
N. Barden, W. D. Matthews, M G Caron, A. J. Krog, R. M. DeMarinis, John W. Regan, J. P. Hieble, K. G. Holden, Robert J. Lefkowitz
Catecholamines, such as epinephrine, inhibit the enzyme adenylate cyclase (EC 4.6.1.1) via a specific receptor mechanism involving α 2 -adrenergic receptors. In order to facilitate purification of these inhibitory receptors we have prepared a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e29e498d4ccb92c50d49b8e2fe736d0
https://europepmc.org/articles/PMC347311/
https://europepmc.org/articles/PMC347311/
Autor:
J P, Hieble, A C, Sulpizio, A J, Nichols, R M, DeMarinis, F R, Pfeiffer, P G, Lavanchy, R R, Ruffolo
Publikováno v:
Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 4(6)
It is now recognized that two post-junctional alpha-adrenoceptors mediate vascular constriction. The vascular alpha 2-adrenoceptors seem to be particularly sensitive to circulating catecholamine levels, in contrast to the alpha 1-adrenoceptors, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0241f3c77481b6f98f3603728755ff8e
https://pubmed.ncbi.nlm.nih.gov/2886570
https://pubmed.ncbi.nlm.nih.gov/2886570