Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. M. Crooke"'
Autor:
Philip L. Felgner, Carl J. Wheeler, Jiin Felgner, Y. J. Tsai, D Mirejovsky, R M Crooke, C F Bennett, C.N. Sridhar
Publikováno v:
Journal of Drug Targeting. 5:149-162
A series of 2,3-dialkyloxypropyl quaternary ammonium lipids containing hydroxyalkyl chains on the quaternary amine were synthesized, formulated with dioleoylphosphatidylethanolamine (DOPE) and assayed for their ability to enhance the activity of an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dce4725605bdb057705dffb3f8220b
https://doi.org/10.3109/10611869808995870
https://doi.org/10.3109/10611869808995870
Publikováno v:
Biochemical pharmacology. 62(3)
The pharmacokinetics of ISIS 1082, a 21-base heterosequence phosphorothioate oligodeoxynucleotide, were characterized within rodent whole liver, and cellular and subcellular compartments. Cross-species comparisons were performed using Sprague-Dawley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a89927f3d63fa67f94cd7f8cee6ac339
https://pubmed.ncbi.nlm.nih.gov/11434902
https://pubmed.ncbi.nlm.nih.gov/11434902
Autor:
M, Butler, R M, Crooke, M J, Graham, K M, Lemonidis, M, Lougheed, S F, Murray, D, Witchell, U, Steinbrecher, C F, Bennett
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(2)
It has been suggested that binding of phosphorothioate oligodeoxynucleotides (P=S ODNs) to macrophage scavenger receptors (SR-AI/II) is the primary mechanism of P=S ODN uptake into cells in vivo. To address the role of scavenger receptors in P=S ODN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c606094ae21920d80abcd6367903766
https://pubmed.ncbi.nlm.nih.gov/10640284
https://pubmed.ncbi.nlm.nih.gov/10640284
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(1)
Phosphorothioate antisense oligodeoxynucleotides are novel therapeutic agents designed to selectively and specifically inhibit production of various disease-related gene products. In vivo pharmacokinetic experiments indicate that these molecules are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84c1b0eb2ac08fe33c45f23158745a06
https://pubmed.ncbi.nlm.nih.gov/10604941
https://pubmed.ncbi.nlm.nih.gov/10604941
Autor:
M J, Graham, S T, Crooke, D K, Monteith, S R, Cooper, K M, Lemonidis, K K, Stecker, M J, Martin, R M, Crooke
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(1)
In the rat, the liver represents a major site of phosphorothioate oligodeoxynucleotide deposition after i.v. administration. For this reason, we examined the intracellular fate of ISIS 1082, a 21-base heterosequence phosphorothioate oligodeoxynucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eee0651e48813e3c63e5bf3b2ca8a27a
https://pubmed.ncbi.nlm.nih.gov/9655890
https://pubmed.ncbi.nlm.nih.gov/9655890
Autor:
R. M. Crooke
Publikováno v:
Antisense Research and Application ISBN: 9783642637308
Eighteen years ago, Zamecnik and Stephenson used synthetic antisense oligonucleotides to inhibit Rous sarcoma virus replication and RNA translation in a cellular system ([Zamecnix and Stephenson 1978]). Since that time, enormous progress has been mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41fad22c4f4c2e0ef3af3ade5a04145
https://doi.org/10.1007/978-3-642-58785-6_3
https://doi.org/10.1007/978-3-642-58785-6_3
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
ISIS 2105 (Afovirsen), a 20-mer phosphorothioate oligonucleotide that inhibits the production of a gene product essential to the growth of human papillomavirus, is in phase II clinical trials for the treatment of genital warts induced by human papill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efa833fc991bff396f3cce3a25fe58b2
https://pubmed.ncbi.nlm.nih.gov/7562586
https://pubmed.ncbi.nlm.nih.gov/7562586
Phosphorothioate oligonucleotides complementary to mRNA of the human cytomegalovirus (HCMV) DNA polymerase gene or to RNA transcripts of the major immediate-early regions 1 and 2 (IE1 and IE2) of HCMV were evaluated for antiviral activity in a 96-wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50b855b181a4481cc874bf5dc30d0b0
https://europepmc.org/articles/PMC188097/
https://europepmc.org/articles/PMC188097/
Publikováno v:
Antimicrobial agents and chemotherapy. 36(3)
ISIS 1082, a phosphorothioate oligonucleotide targeted to a translation initiation codon of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) virion capsid protein UL13 inhibits in vitro viral replication. To better understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90878db30c1ef4255c295fef75e82de1
https://pubmed.ncbi.nlm.nih.gov/1377898
https://pubmed.ncbi.nlm.nih.gov/1377898
Autor:
R M, Crooke
Publikováno v:
Anti-cancer drug design. 6(6)
The ability to rationally design antisense drugs and the theoretical selectivity of these compounds for specific genomic and viral mRNA targets make their use as therapeutic agents extremely attractive. Pharmacologic data emerging from our and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9cb98b2b36ddd2bca45cef37d96aed5
https://pubmed.ncbi.nlm.nih.gov/1772572
https://pubmed.ncbi.nlm.nih.gov/1772572