Zobrazeno 1 - 10
of 158
pro vyhledávání: '"R. M. Blaese"'
Autor:
S Walbridge, M Shah, Q Li, Takashi Okada, R M Blaese, Oliver Wildner, James N. Higginbotham, Edward H. Oldfield, WJ Ramsey
Publikováno v:
Gene Therapy. 8:1315-1322
Gene transfer vectors expressing herpes simplex thymidine kinase (HSVtk), in addition to direct killing of tumor cells, often have an associated local "bystander effect" mediated by metabolic coupling of tumor cells. A systemic antitumor effect media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95a3f25811efb4ed1b4b4cf675525a7
https://doi.org/10.1038/sj.gt.3301526
https://doi.org/10.1038/sj.gt.3301526
Publikováno v:
Human Gene Therapy. 10:2679-2687
An established principle of antineoplastic chemotherapy is that multidrug regimens are generally superior to single-agent therapy. This prompted us to elucidate whether the topoisomerase inhibitor topotecan (TPT) could enhance the efficacy of the her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c189ba0288bbd808cd92b54ba6c48a3
https://doi.org/10.1089/10430349950016726
https://doi.org/10.1089/10430349950016726
Publikováno v:
Gene Therapy. 5:1705-1711
The bystander effect (BSE) is an interesting and important property of the herpes thymidine kinase/ganciclovir (hTK/GCV) system of gene therapy for cancer. With the BSE, not only are the hTK expressing cells killed upon ganciclovir (GCV) exposure but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6685c60ec35cd6c5fd44c29f9f730714
https://doi.org/10.1038/sj.gt.3300784
https://doi.org/10.1038/sj.gt.3300784
Publikováno v:
Human Gene Therapy. 8:911-917
Disorders in which there is toxic buildup of circulating substrate may be treated by furnishing an enzyme reservoir capable of metabolically processing the excess substrate. The epidermal keratinocyte is a potential site for such a reservoir. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fa4939122964a981a35df319fc555b
https://doi.org/10.1089/hum.1997.8.8-911
https://doi.org/10.1089/hum.1997.8.8-911
Autor:
R M Blaese
Publikováno v:
Hospital Practice. 30:33-40
Hopes for correcting the instruction tape in patients with genetic disease are being intensively explored. Initial efforts centered on monogenic immunodeficiency states, but in a pattern not wholly expected by researchers, the "acquired genetic disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f86a1d8d74eed349370229ebf2cbe0
https://doi.org/10.1080/21548331.1995.11443286
https://doi.org/10.1080/21548331.1995.11443286
Autor:
Qili Zhu, R. M. Blaese, Michael Y. Zhang, Uta Francke, A. K. Junker, HansD. Ochs, J. M. J. Derry, S.-H. Chen
Publikováno v:
Blood. 86:3797-3804
The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, small platelets, eczema, recurrent infections, and immunodeficiency. Besides the classic WAS phenotype, there is a group of patients with congenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595448e6494bd1869b1d96048226b79e
https://doi.org/10.1182/blood.v86.10.3797.bloodjournal86103797
https://doi.org/10.1182/blood.v86.10.3797.bloodjournal86103797
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7739-7743
Peripheral blood lymphocytes (PBLs) are primary targets for gene therapy of inherited and acquired disorders of the immune system. We describe the development of an optimized transduction system that provides for high-efficiency retrovirus-mediated g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6140b1971720d9e0a8ce6516c344a5ea
https://doi.org/10.1073/pnas.92.17.7739
https://doi.org/10.1073/pnas.92.17.7739
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4706-4710
The Wiskott-Aldrich syndrome (WAS) is an X-chromosome-linked recessive disease characterized by eczema, thrombocytopenia, and immunodeficiency. The disease gene has been localized to the proximal short arm of the X chromosome and recently isolated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d4677f33e96800fcd6ddc77a321bbb
https://doi.org/10.1073/pnas.92.10.4706
https://doi.org/10.1073/pnas.92.10.4706
Autor:
R. M. Blaese, John D. Heiss, Kenneth W. Culver, Edward H. Oldfield, Zvi Ram, Stuart Walbridge
Publikováno v:
Journal of Neurosurgery. 80:535-540
✓ The authors have recently shown the feasibility of eradicating brain tumors usingin vivoretroviral-mediated transduction of tumors with the herpes simplex thymidine kinase (HStk) gene and ganciclovir therapy. However, thymidine kinase-transduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8024c46494d0b9db2aae5404c539f26
https://doi.org/10.3171/jns.1994.80.3.0535
https://doi.org/10.3171/jns.1994.80.3.0535
Publikováno v:
Blood. 82:2961-2966
This study describes the effects of two major treatment options, splenectomy and/or bone marrow transplantation, on the natural history of the Wiskott-Aldrich (WAS) syndrome. The records of 62 patients with the WAS evaluated at the National Institute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::243ec1cafffb030a0ffc0c667eb7b860
https://doi.org/10.1182/blood.v82.10.2961.2961
https://doi.org/10.1182/blood.v82.10.2961.2961