Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R. M. Barstad"'
Publikováno v:
Thrombosis and Haemostasis. 83:334-337
SummaryPlatelet adhesion to the injured vessel wall is essential in haemostasis and thrombosis. This process involves the interaction of the platelet glycoprotein Ib (GPIb) with surface bound von Willebrand factor (vWF). Since synthetic polycationic
Publikováno v:
Thrombosis and Haemostasis. 79:302-305
SummaryHeparin-coating improves the biocompatibility of blood contacting artificial surfaces. This led us to investigate the impact of heparin-coating (Carmeda AB, Stockholm) of polymetylmetacrylate on the expression of monocyte tissue factor procoag
Autor:
Nils Olav Solum, Kjell S. Sakariassen, U. Ørvim, Frank Brosstad, R. M. Barstad, Pål Andre Holme, M. J. A. G. Hamers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 17:646-653
Abstract In the present study, we investigated whether high arterial shear stresses at various exposure times or a sudden increase in shear stress introduced by a stenosis affect platelet activation and platelet microparticle formation in native huma
Autor:
F. P. Brosstad, Kjell S. Sakariassen, Geir E. Tjønnfjord, M. J. A. G. Hamers, Una Ørvim, R. M. Barstad
Publikováno v:
Thrombosis and Haemostasis. 75:827-832
SummaryAspirin is the most commonly used antithrombotic drug in primary and secondary prophylaxis against cardio- and cerebrovascular disease. In previous studies from our laboratory it was demonstrated that the effect of aspirin on collagen-induced
Autor:
M. J. A. G. Hamers, M. S. Buchmann, Helge Stormorken, Kjell S. Sakariassen, L. Örning, U. Ørvim, R. M. Barstad
Publikováno v:
Acta Radiologica. 37:954-961
Background: The aims of the present study were to investigate whether ionic and nonionic contrast media (CM) affect: 1) the procoagulant and fibrinolytic activities of cultured human vessel endothelium; and 2) early events of tissue-factor-induced ar
Publikováno v:
Thrombosis and Haemostasis. 75:685-692
SummaryAtherosclerotic plaque rupture may trigger the formation of a mural thrombus. This thrombus formation is apparently affected by very high and complex shear conditions introduced by the luminal narrowing (stenosis) of the atheroma. To study the
Publikováno v:
Blood. 86:212-218
Agents that downregulate the induction of monocyte/macrophage tissue factor (TF) activity may attenuate the thrombotic risk associated with mechanical restoration of vessel patency or artificial arterial grafting. In such events, procoagulant macroph
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 15:11-16
Abstract Tissue factor (TF) on monocyte and macrophage surfaces is a nonproteolytic cofactor for factor VIIa (FVIIa)–induced coagulation. Monocyte-derived macrophages in atherosclerotic plaques express TF, which, after plaque disruption or rupture,
Autor:
Helge Stormorken, Ross W. Stephens, Lars Örning, P. Kierulf, R. M. Barstad, Kjell S. Sakariassen, Lizette B. Petersen
Publikováno v:
Blood. 84:3371-3377
Inhibition of thrombin formation in flowing native blood reduces thrombus formation on subendothelium, dacron, or collagen fibrils at arterial wall shear rates of 450 to 650 s-1. In the present study, we have investigated the role of low levels of fa
Publikováno v:
Thrombosis and Haemostasis. 71:103-109
SummaryIn the present study we have investigated the effect of a 100 mg single oral dose of a newly developed thromboxane A2 receptor antagonist on collagen-induced thrombogenesis in flowing human non-anticoagulated blood. Blood was drawn directly fr