Zobrazeno 1 - 10
of 65
pro vyhledávání: '"R. M. ADLINGTON"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2003-2006
4-Hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 2-oxo-5-thiahexanoic acid 1 , the ketoacid from methionine (Scheme 1) to an unequal mixture of 4-thiapentanoic acid-4-oxide enantiomers 2a .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a168060762a819274e94cb5af841d09
https://doi.org/10.1016/0960-894x(96)00362-9
https://doi.org/10.1016/0960-894x(96)00362-9
Publikováno v:
Tetrahedron Letters. 36:7925-7928
Di-α-alkylated-α-(β-keto sulfone) alkynes provide a facile entry to trisubstituted allenes upon treatment with aluminium amalgam.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1e33ba6267f74f7dec43f40537ce0a
https://doi.org/10.1016/0040-4039(95)01643-v
https://doi.org/10.1016/0040-4039(95)01643-v
Publikováno v:
Tetrahedron. 49:7837-7856
A stereospecific synthesis of the cyclic tetrapeptide chlamydocin via free radical homologation from a ( S )-2-amino-5-iodopentanoic acid containing cyclic tetrapeptide is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::868f49e76b4fb608a249f57ec1b09d10
https://doi.org/10.1016/s0040-4020(01)88010-8
https://doi.org/10.1016/s0040-4020(01)88010-8
Publikováno v:
ChemInform. 22
Incubation of δ-L-α-aminoadipoyl-L-cysteinyl-D-propargylglycine (3) and δ-L-α-aminoadipoyl-L-cysteinyl-D-cyanoalanine (4) with Isopenicillin N synthase resulted in the formation of three novel penicillin antibiotics, possessing unsaturated side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd5840e47128b6f32f94e68e21461d1
https://doi.org/10.1002/chin.199104090
https://doi.org/10.1002/chin.199104090
Publikováno v:
ChemInform. 22
Incubation of δ-L-α-aminoadipoyl-L-[3-13Ccysteinyl-D-[3-2H]valine with Isopenicillin N Synthase (IPNS) resulted in the observation of a ‘shunt metabolite’, which we believe is formed from the collapse of an enzyme bound monocyclic β-lactam int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f66375b7554590b7330af5fca2b6a54
https://doi.org/10.1002/chin.199116259
https://doi.org/10.1002/chin.199116259
Autor:
Nicholas P. Crouch, Nicholas J. Turner, R. M. Adlington, Robin T. Aplin, Jack E. Baldwin, Christopher J. Schofield
Publikováno v:
ChemInform. 23
Incubation of penicillin N ( 3a ) with partially purified deacetoxy/deacetylcephalosporin C synthase (DAOC/DAC synthase) from Cephalosporium acremonium CO 728 gave in addition to the expected products, deacetoxycephalosporin C and deacetylcephalospor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5fc994ba35618f409df67a54684fe7
https://doi.org/10.1002/chin.199211062
https://doi.org/10.1002/chin.199211062
Autor:
Christopher R. A. Godfrey, Jack E. Baldwin, R. M. Adlington, D. W. Gollins, Christopher J. Schofield
Publikováno v:
ChemInform. 22
The first stereospecific synthesis of the naturally occuring dipeptide antibiotic, alahopcin, starting from ( L -aspartic acid is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d748b33e6a94cdd2dd2869ee36ba7cbc
https://doi.org/10.1002/chin.199143234
https://doi.org/10.1002/chin.199143234
Publikováno v:
ChemInform. 22
The three tripeptides δ- L -α-aminoadipoyl- L -cysteinyl- D -propargylglycine, δ- L -α-aminoadipoyl- L -cysteinyl- D -cyanoalanine and δ- L -α-aminoadipoyl- L -cysteinyl- D -[4,4,5,5-2H4]-norvaline were synthesised and incubated with the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fee8ca4320096b977d7cd6ac0275d98
https://doi.org/10.1002/chin.199140254
https://doi.org/10.1002/chin.199140254
Autor:
Christopher J. Schofield, R. M. Adlington, Simon W. Leppard, Wendy J. Sobey, Mark E. Wood, Jack E. Baldwin, Janos Pitlik, Nicholas P. Crouch, John W. Keeping
Publikováno v:
ChemInform. 23
Cyclopropyl substituted cephalosporin analogues were prepared and evaluated as substrates for the FeII/α-ketoglutarate dependent oxygenase, DAOC–DAC synthase; the first example of catalytic product formation from a Cyclopropyl ring cleavage pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494e2d411bd643a0c1dd7aa536686e61
https://doi.org/10.1002/chin.199210297
https://doi.org/10.1002/chin.199210297
Publikováno v:
ChemInform. 24
The use of a deuterium kinetic isotope effect has enabled the isolation and characterisation of a novel epoxide metabolite produced in the enzymic conversion of [4-2H]exomethylene cephalosporin C into deacetylcetylcephalosporin C catalysed by the enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759130bc3d3317ffc0a950d06aafd6ba
https://doi.org/10.1002/chin.199303281
https://doi.org/10.1002/chin.199303281