Zobrazeno 1 - 10
of 137
pro vyhledávání: '"R. Luke Wiseman"'
Autor:
Jessica D. Rosarda, Sarah Giles, Sarah Harkins-Perry, Elizabeth A. Mills, Martin Friedlander, R. Luke Wiseman, Kevin T. Eade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in re
Externí odkaz:
https://doaj.org/article/66ae003ca45c4b5cb11a67b2487be644
Autor:
Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABAA subunits
Externí odkaz:
https://doaj.org/article/569f39d2a4334662858040e0811c4d49
Autor:
Aparajita Madhavan, Bernard P. Kok, Bibiana Rius, Julia M. D. Grandjean, Adekunle Alabi, Verena Albert, Ara Sukiasyan, Evan T. Powers, Andrea Galmozzi, Enrique Saez, R. Luke Wiseman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Signalling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects in obesity. Here the authors report that a selective pharmacologic activator of IRE1/XBP1s signalling stimulates an adaptive remodelling of li
Externí odkaz:
https://doaj.org/article/8188d276e8de4e5c9c51dd25ed502203
Autor:
Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this importan
Externí odkaz:
https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
Autor:
Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf, Ryan J. Paxman, Lars Plate, Jeffery W. Kelly, R. Luke Wiseman, Christopher C. Glembotski
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo
Externí odkaz:
https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
Autor:
Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ethan M. Smith-Cohen, Julia M. D. Grandjean, Jeffery W. Kelly, Joseph C. Genereux, R. Luke Wiseman
Publikováno v:
Cells, Vol 11, Iss 10, p 1661 (2022)
The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce the toxic, extracellular aggregation of TTR is to decrease the pop
Externí odkaz:
https://doaj.org/article/f3fc60b872b44c86b916574de21b8382
Autor:
Justine Lebeau, Jaclyn M. Saunders, Vivian W.R. Moraes, Aparajita Madhavan, Nicole Madrazo, Mary C. Anthony, R. Luke Wiseman
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2827-2836 (2018)
Summary: Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with pathologic mitochondrial dysfunction in diverse diseases. The PERK arm of the unfolded protein response (UPR) protects mitochondria during ER stress thro
Externí odkaz:
https://doaj.org/article/e1b2e5cf7382450eb3e5d274dd5be743
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2041-2049 (2016)
The mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essential mitochondrial functions, including inner membrane proteostasis maintenance and mitochondrial dynamics. Here, we show that YME1L and OMA1 are reciprocally d
Externí odkaz:
https://doaj.org/article/4bf7d7f47135477596a0f1ac0406bd54
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 1025 (2020)
The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap‘n’collar transcriptional regulators which modulate the expression of genes harboring antioxidant-response element (ARE) sequences within their genomic loci. Despite the emerg
Externí odkaz:
https://doaj.org/article/a68326cf2a6f41218b5aa6e3095085ad
Autor:
Oktay Kirak, Eugene Ke, Kevin Y. Yang, Anna Schwarz, Lars Plate, Amy Nham, Justin R. Abadejos, Anna Valencia, R. Luke Wiseman, Kathy O. Lui, Manching Ku
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5743 (2020)
Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contri
Externí odkaz:
https://doaj.org/article/0e83cc75d46c41f4aa337d107bf856ad