Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients

Autor: P, Aviles, R, Altares, L, van Andel, R, Lubomirov, S, Fudio, H, Rosing, F M, Márquez Del Pino, M M, Tibben, G, Benedit, L, Nan-Offeringa, X E Luepke, Estefan, A, Francesch, A, Zeaiter, C, Cuevas, J H M, Schellens, J H, Beijnen

Publikováno v: Drug Metabolism and Disposition. 50:327-340

Lurbinectedin is a novel and potent selective inhibitor of active transcription of protein-coding genes, triggering apoptosis of cancerous cells. It has been approved for the treatment of patients with metastatic small-cell lung cancer with disease p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ec718d13167a8c56d00b5f1d9a031b
https://doi.org/10.1124/dmd.121.000668

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of

Autor: L, van Andel, H, Rosing, M M, Tibben, L, Lucas, R, Lubomirov, P, Avilés, A, Francesch, S, Fudio, A, Gebretensae, M J X, Hillebrand, J H M, Schellens, J H, Beijnen

Publikováno v: Cancer chemotherapy and pharmacology. 82(3)

Plitidepsin absorption, distribution, metabolism and excretion characteristics were investigated in a mass balance study, in which six patients received a 3-h intravenous infusion containing 7 mgBlood samples were drawn and excreta were collected unt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a79acbab73ba6eeaae3e198aa245536e
https://pubmed.ncbi.nlm.nih.gov/29974200

Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population

Autor: Jose Carlos Martinez Avila, Mario Muñoz, María Jesús Blanco Bañares, Carmen F. Capitán, Alberto M. Borobia, Antonio J. Carcas, Rafael Hernández, Elena Ramírez, Jesús Frías, Hoi Y. Tong, R. Lubomirov

Publikováno v: Pharmacogenomics. 18(8)

Aim: To evaluate the influence of two variants of P450 oxidoreductase (POR), rs2868177 and POR*28, on the stable dosage of acenocoumarol. Patients & methods: For this observational, cross-sectional study, patients were undergone stable anticoagulant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153f0a4a3eebab3e59820c336edfd3c9
https://pubmed.ncbi.nlm.nih.gov/28592191

A new pharmacogenetic algorithm to predict the most appropriate dosage of acenocoumarol for stable anticoagulation in a mixed Spanish population

Autor: Xando Díaz-Villamarín, Hoi Y. Tong, Luis Javier Martinez-Gonzalez, María Jesús Blanco Bañares, R. Lubomirov, Cristina Lucía Dávila-Fajardo, Laura María Perea León, José Cabeza Barrera, Alberto M. Borobia, Antonio J. Carcas, Carmen Fernández-Capitán

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
PLoS ONE, Vol 11, Iss 3, p e0150456 (2016)
PLoS ONE
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.There is a stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa1be8e9dcefd79189a05363d54e879
http://hdl.handle.net/10486/677927