Zobrazeno 1 - 10
of 706
pro vyhledávání: '"R. Lowenstein"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Oncostreams are self-organized structures formed by spindle-like, elongated, self-propelled cells recently described in glioblastomas and especially in gliosarcomas. Cells within these structures either move as large clusters in one main dir
Externí odkaz:
https://doaj.org/article/daaf54ccec1142cb803fdcd2a617f51f
Autor:
Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-14 (2024)
Abstract Histone deacetylases (HDACs) have a wide range of targets and can rewire both the chromatin and lipidome of cancer cells. In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhi
Externí odkaz:
https://doaj.org/article/ecf370d8942a4622b169a6b1429e57e4
Autor:
Iulia Tapescu, Peter J. Madsen, Pedro R. Lowenstein, Maria G. Castro, Stephen J. Bagley, Yi Fan, Steven Brem
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Originally devised for cancer control, mRNA vaccines have risen to the forefront of medicine as effective instruments for control of infectious disease, notably their pivotal role in combating the COVID-19 pandemic. This review focuses on fundamental
Externí odkaz:
https://doaj.org/article/0e9534d7859743ec97b686ecc2e43474
Autor:
Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f17ac9f48872451c8adf495dc087b9f1
Autor:
Syed M. Faisal, Jarred E. Clewner, Brooklyn Stack, Maria L. Varela, Andrea Comba, Grace Abbud, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis showing only a 5% survival rate beyond two years. This is primarily due to its aggressiveness and intra‐tumoral heterogeneity, which limits complete surgical
Externí odkaz:
https://doaj.org/article/1538c238cfc34c618bb0253cf99982f3
Autor:
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to p
Externí odkaz:
https://doaj.org/article/2f813af486a84bc6939ddacebcf2e7f8
Autor:
Andrea Comba, Maria Luisa Varela, Syed M. Faisal, Clifford C. Abel, II, Anna E. Argento, Wajd N. Al-Holou, Todd C. Hollon, Jacqueline D. Perelman, Patrick J. Dunn, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102174- (2023)
Summary: Development of spatial-integrative pre-clinical models is needed for glioblastoma, which are heterogenous tumors with poor prognosis. Here, we present an optimized protocol to generate three-dimensional ex vivo explant slice glioma model fro
Externí odkaz:
https://doaj.org/article/2c43e2be55634ce0ab0275ab171a6f0b
Autor:
Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, Todd C. Hollon, Wajd N. Al-Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar L. Quass, Pierre F. Apostolides, Clifford Abel, Christine E. Brown, Phillip E. Kish, Alon Kahana, Celina G. Kleer, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
It is essential to improve our understanding of the features that influence aggressiveness and invasion in high grade gliomas (HGG). Here, the authors characterize dynamic anatomical structures in HGG called oncostreams, which are associated with tum
Externí odkaz:
https://doaj.org/article/3b351a9de1174a41bae1168e3664c972
Autor:
Brandon L. McClellan, Santiago Haase, Felipe J. Nunez, Mahmoud S. Alghamri, Ali A. Dabaja, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis, tumor progression, and responses to immunotherapies, as well as deter
Externí odkaz:
https://doaj.org/article/6308066ce446495b9c5b231dbe2583e6
Autor:
Santiago Haase, Kaushik Banerjee, Anzar A. Mujeeb, Carson S. Hartlage, Fernando M. Núñez, Felipe J. Núñez, Mahmoud S. Alghamri, Padma Kadiyala, Stephen Carney, Marcus N. Barissi, Ayman W. Taher, Emily K. Brumley, Sarah Thompson, Justin T. Dreyer, Caitlin T. Alindogan, Maria B. Garcia-Fabiani, Andrea Comba, Sriram Venneti, Visweswaran Ravikumar, Carl Koschmann, Ángel M. Carcaboso, Maria Vinci, Arvind Rao, Jennifer S. Yu, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode Gly34Arg/Val substitutions in the histone H3.3 (H3.3-G34R/V). The mechani
Externí odkaz:
https://doaj.org/article/86291c23bf8d4ccda5764eae5949072f