Výsledky vyhledávání

Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity

Autor: Alicia R. Locker, Julie V. Miller, Kimberly Sullivan, Diane B. Miller, James P. O'Callaghan, Rotem Ben-Hamo, Lindsay T. Michalovicz, Kimberly A. Kelly, Saurabh Vashishtha, Sol Efroni, Gordon Broderick

Publikováno v: Journal of Neurochemistry

Neurotoxicology is hampered by the inability to predict regional and cellular targets of toxicant‐induced damage. Evaluating astrogliosis overcomes this problem because reactive astrocytes highlight the location of toxicant‐induced damage. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ededbb410552535863f5fec616d35cc
https://doi.org/10.1111/jnc.14800

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Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness

Autor: Zachary Barnes, Diane B. Miller, Nancy G. Klimas, Mariana Morris, Julie V. Miller, James P. O'Callaghan, Alicia R. Locker, Lindsay T. Michalovicz, Mary A Fletcher, Kimberly A. Kelly, Stephen M. Lasley

Publikováno v: Neurotoxicology

Gulf War Illness (GWI) is a chronic multi-symptom disorder experienced by as many as a third of the veterans of the 1991 Gulf War; the constellation of “sickness behavior” symptoms observed in ill veterans is suggestive of a neuroimmune involveme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2586ce976bc2d59c46177be5e07af331
https://doi.org/10.1016/j.neuro.2018.10.006

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The Neuroinflammatory Phenotype in a Mouse Model of Gulf War Illness is Unrelated to Brain Regional Levels of Acetylcholine as Measured by Quantitative HILIC-UPLC-MS/MS

Autor: Anand Ranpara, Julie V. Miller, Lindsay T. Michalovicz, Diane B. Miller, Ryan F. LeBouf, Kimberly A. Kelly, James P. O'Callaghan, Alicia R. Locker

Publikováno v: Toxicological Sciences. 165:302-313

Many veterans of the 1991 Persian Gulf War (GW) returned with a chronic multisymptom illness that has been termed Gulf War Illness (GWI). Previous GWI studies have suggested that exposure to acetylcholinesterase inhibitors (AChEIs) in theater, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beed36276e380b494d16e195f05ec12
https://doi.org/10.1093/toxsci/kfy130

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Corticosterone primes the neuroinflammatory response to Gulf War Illness‐relevant organophosphates independently of acetylcholinesterase inhibition

Autor: Julie V. Miller, James P. O'Callaghan, Kimberly A. Kelly, Diane B. Miller, Lindsay T. Michalovicz, Alicia R. Locker

Publikováno v: Journal of Neurochemistry

Gulf War Illness (GWI) is a chronic multi‐symptom disorder affecting veterans of the 1991 Gulf War. Among the symptoms of GWI are those associated with sickness behavior, observations suggestive of underlying neuroinflammation. We have shown that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faead785ec2267b70a494de6f66e8b11
https://doi.org/10.1111/jnc.14071

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Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice

Autor: Michael J. Marks, Helen M. Kamens, Alicia R. Locker, Laura Cousino Klein

Publikováno v: Brain Research Bulletin. 123:13-22

Nearly 80% of adult smokers begin smoking during adolescence. Binge alcohol consumption is also common during adolescence. Past studies report that nicotine and ethanol activate dopamine neurons in the reward pathway and may increase synaptic levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db650a89b8ca442fdfc35944f613c2ec
https://doi.org/10.1016/j.brainresbull.2015.09.009

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Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness

Autor: Alicia R. Locker, Kimberly A. Kelly, Stephen M. Lasley, James P. O'Callaghan, Diane B. Miller

Publikováno v: Journal of Neurochemistry

Gulf War Illness (GWI) is a multi‐symptom disorder with features characteristic of persistent sickness behavior. Among conditions encountered in the Gulf War (GW) theater were physiological stressors (e.g., heat/cold/physical activity/sleep depriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7b96b2a4f4d60f8812f5b00cf4afcf
https://doi.org/10.1111/jnc.13088

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Submicroscopic deletions and duplications in individuals with intellectual disability detected by array-CGH

Autor: Sylvie Langlois, Lorne A. Clarke, Laura Arbour, Christine Tyson, M I Van Allen, Jan M. Friedman, Evica Rajcan-Separovic, Chansonette Harvard, B. McGilivray, Martin J. Somerville, R. Locker, Siu-Li Yong, M. E. S. Lewis, J. Siegel-Bartel

Publikováno v: American Journal of Medical Genetics Part A. :173-185

Intellectual disability (ID) affects about 3% of the population (IQ < 70), and in about 40% of moderate (IQ 35-49) to severe ID (IQ < 34), and 70% of cases of mild ID (IQ 50-70), the etiology of the disease remains unknown. It has long been suspected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e225cb1b74c773b1abe92e6ca6f3e3a7
https://doi.org/10.1002/ajmg.a.31015

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Genomic FISHing: data analysis for chromosomal imbalances using DNA arrays

Autor: N. Dzidic, M. Mohammed, R. Locker, J. Kang, J. Kim, S. Shah

Publikováno v: Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

Microarrays for genomic analysis pose a rather serious challenge for statistical inference on the quality of data. With the ability to attach large genomic fragments on the array substrate, it is now possible to search for chromosomal imbalances rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0715dac1de6502c7ac5e1215607d7744
https://doi.org/10.1109/iembs.2002.1053233

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Economic burden of agricultural machinery injuries in Ontario, 1985 to 1996

Autor: John Dorland, William Pickett, Lisa Hartling, Alison R. Locker

Publikováno v: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association. 19(3)

CONTEXT: Agricultural injuries are an important and understudied category of occupational injuries. PURPOSE: This study estimated the economic burden of agricultural machinery injuries that occurred in Ontario, Canada's largest province, between 1985

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa300a8df27e657c03d533bd917e1f31
https://pubmed.ncbi.nlm.nih.gov/12839137

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Agricultural machinery injuries in Ontario, 1985-1996: a comparison of males and females

Autor: Alison R. Locker, William Pickett, Lisa Hartling, John Dorland

Publikováno v: Journal of agricultural safety and health. 8(2)

Males and females on farms perform different types of work. This study investigated whether certain injuries experienced by women and men on farms also differed. Gender–based comparisons were made of fatal and hospitalized agricultural machinery in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2a3d309988c3f985c8621d95bbc095
https://pubmed.ncbi.nlm.nih.gov/12046807

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