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The genomic landscape of TERT alterations in bladder cancer

Autor: Aimee Jalkanen, Gargi D. Basu, David W. Hall, Jess R Hoag, Janine R. LoBello, Frederick L. Baehner, Snehal Govind Thakkar, Tanya B. Dorff

Publikováno v: Journal of Clinical Oncology. 41:551-551

551 Background: Some of the most common mutations seen across cancers occur in TERT, where promoter mutations upregulate TERT transcription. In bladder cancer, TERT mutations are associated with poor prognosis, especially for recurrence. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31bce4f363b7fb04fe6a226717524ccd
https://doi.org/10.1200/jco.2023.41.6_suppl.551

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Prevalence and genomic landscape of BRAF alterations across gastrointestinal cancers

Autor: David Driscoll, Min Wang, Fadel S. Alyaqoub, Sameer S. Udhane, Szabolcs Szelinger, Aimee Jalkanen, David W. Hall, Jess R Hoag, Janine R. LoBello, Frederick L. Baehner, Snehal Govind Thakkar, Gargi D. Basu

Publikováno v: Journal of Clinical Oncology. 41:806-806

806 Background: BRAF V600E mutations can lead to activation of the MEK/ERK pathway. The combination of dabrafenib plus trametinib was recently FDA-approved for use in these BRAF V600E altered unresectable or metastatic cancers. BRAF non-V600 alterati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14ff5a3a6ef1a776ed3acbe2cac0c5a8
https://doi.org/10.1200/jco.2023.41.4_suppl.806

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Abstract 1263: Comprehensive genomic profiling to identify biomarkers predictive of response to immunotherapy

Autor: Pawan Noel, David W. Hall, Sameer S. Udhane, Min Wang, Fadel S. Alyaqoub, Szabolcs Szelinger, Audrey A. Ozols, Janine R. LoBello, Frederick L. Baehner, Gargi D. Basu

Publikováno v: Cancer Research. 82:1263-1263

Background: Immune-oncology (I-O) drugs show promise across multiple tumor types, and several biomarkers (BM) predict responsiveness to I-O therapy. In this descriptive study of clinical lab experience (2018-2021), we investigated the prevalence of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef4d2888a2cdc5a69b8e269a1924dc95
https://doi.org/10.1158/1538-7445.am2022-1263

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Comprehensive genomic profiling to identify gene alterations in DNA repair pathway across solid tumors

Autor: Kevin McDonnell, Gargi D. Basu, Jess W. Hoag, David W. Hall, Fadel S. Alyaqoub, Susan M. Dombrowski, Pawan Noel, Szabolcs Szelinger, Sameer S. Udhane, Min Wang, Janine R. LoBello, Snehal Govind Thakkar, Frederick L. Baehner, Christine Hong, Wai Park, Gregory Idos, Stacy W. Gray, Stephen B. Gruber

Publikováno v: Journal of Clinical Oncology. 40:3124-3124

3124 Background: Deleterious events in DNA damage response (DDR) are hallmarks of cancer associated with sensitivity to PARP inhibitors (PARPi) and immune checkpoint inhibitors (CPI). This study investigated DDR pathway alterations across solid tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d09da0f0e1f365ecde60377964efe6
https://doi.org/10.1200/jco.2022.40.16_suppl.3124

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Comprehensive whole-exome and transcriptome profiling to identify actionable alterations associated with response to PARP inhibitors in breast cancer

Autor: Susan M. Dombrowski, Sameer S. Udhane, Gargi D. Basu, David W. Hall, Jess W. Hoag, Fadel S. Alyaqoub, Pawan Noel, Szabolcs Szelinger, Min Wang, Audrey A. Ozols, Janine R. LoBello, Snehal Govind Thakkar, Frederick L. Baehner, Joyce O'Shaughnessy

Publikováno v: Journal of Clinical Oncology. 40:1096-1096

1096 Background: The use of targeted therapies identified using genetic and genomic approaches is now routine in breast cancer (BC). In this clinical lab experience study the frequency of actionable somatic alterations in DNA repair pathway genes ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c21ce22c8fbaa421b50d5560d70351
https://doi.org/10.1200/jco.2022.40.16_suppl.1096

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Stability and autolysis of cortical neurons in post-mortem adult rat brains

Autor: Sergey V, Sheleg, Janine R, Lobello, Hugh, Hixon, Stephen W, Coons, David, Lowry, Mikhail K, Nedzved

Publikováno v: International journal of clinical and experimental pathology. 1(3)

We investigated the dynamics of autolytic damage of the cortical neurons in adult brains for 24 hours at room temperature (+20 degrees C) after cardiac arrest. The progressive histological and ultrastructural changes were documented using routine and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0be21651323547d05bcded09e579b4f2
https://pubmed.ncbi.nlm.nih.gov/18784829

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