An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials

Autor: Davy Guan, Alexander Wade, Edwin G Tse, Alice Motion, Willem P. van Hoorn, Jonathan Cardoso-Silva, Adele M. Lehane, Giovanni Cincilla, Mario Öeren, Julia C. R. Lindblom, Mykola Galushka, Murray N. Robertson, Matthew H. Todd, James McCulloch, Slade Matthews, Mark G. Anderson, Benedict Irwin, Thomas M. Whitehead, Paul Willis, Laksh Aithani, Ho Leung Ng, Gareth Conduit, Vasileios A. Tatsis, Vito Spadavecchio, Raymond Lui, Kiaran Kirk, Irene Hallyburton

Publikováno v: Journal of medicinal chemistry. 64(22)

The discovery of new antimalarial medicines with novel mechanisms of action is key to combating the problem of increasing resistance to our frontline treatments. The Open Source Malaria (OSM) consortium has been developing compounds ("Series 4") that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226bb29c6cfb2827cc0b24dac6a0807c
https://pubmed.ncbi.nlm.nih.gov/34748707

Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators

Autor: Kenkyo Matsuura, Jeffrey Wojton, Alexander C. Robeson, Kelly R. Lindblom, Sally Kornbluth

Publikováno v: The EMBO Journal

Caspase‐2 has been shown to initiate apoptotic cell death in response to specific intracellular stressors such as DNA damage. However, the molecular mechanisms immediately upstream of its activation are still poorly understood. We combined a caspas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dffed5280771117190511c330e8a499
https://doi.org/10.15252/embj.201797072

Toll-like receptors (PP-001)

Autor: D. J. Weisdorf, C. Svanborg, Q. Wang, P. Ekpo, D. Kim, M. Park, X. Liang, H. J. Kwak, D. Spencer, N. Srisamut, P. Datta, L. Bulat-Kardum, H. D. Ochs, F. E. Sepulveda, L. Song, A. Kariyone, M. Ogasawara, J. Jang, A. Junpee, K. Agematsu, D. R. Stach-Machado, H. Kariya, Daniela Verthelyi, K. Itoh, K. Yamazaki, W. Cheng, K. Miyake, S. Rezania, Q. Zhang, H. O. Bianchi, Y. Takeda, S. M. Kim, C. M. Blum, S. Ohta, J. C. Lee, F. Liu, M. E. Abdalsalam, Y. Sher, J. Cho, N. Nilsen, S. Das, J. Munz, K. A. Fitzgerald, Y. Jung, S. Hellmig, J. Inoue, W. W. Agace, C. Knetter, S. Sasawatari, F. Willems, T. Tomita, S. Akira, C. A. Palha De Sousa, C. L. Zawislak, D. Cole, P. Thuss-Patience, H. Jarmer, T. Espevik, F. Shokri, Ihsan Gursel, H. Yang, J. Seo, C. Gfell, D. H. Kim, J. N. Smith, X. Shen, F. Skjeldal, O. Bakke, E. P. Sgroe, A. Lennon-Dumenil, T. Hayashi, S. Rasmussen, S. Hong, I. Chung, J. Conlon, L. Cabanie, S. Gretschel, Y. Zhang, Y. Sakurai, S. Amigorena, M. Hattori, A. Ta, J. Zhang, H. An, R. A. Kurt, M. A. Zacks, M. Shirakawa, J. S. Rush, N. Parvizzadeh, M. Chen, J. Y. Kang, S. Kim, M. L. Salem, C. Yang, S. Maschalidi, O. Kumpf, X. Cao, J. S. Miller, O. Naga, D. Kanistanon, J. Lee, B. R. Blazar, Y. Liu, V. Flamand, D. Wakita, L. Grajkowska, Özlem Aslan, T. Seya, R. Lindblom, P. Abrahão, C. Ghirelli, N. M. Rachmawati, H. Oshiumi, L. Lu, U. Rungpanich, K. Inaba, E. Moseman, T. Nishimura, F. Piehl, B. Manoury, B. Nøhr Nielsen, T. Sasazuki, C. Lin, J. A. Hamerman, R. Colisson, T. Nakahama, T. Funasaka, W. Bae, A. Hasebe, K. McMichael, B. C. Cole, Y. Suda, G. A. Obando-Pereda, E. K. Ryu, R. F. Ashman, A. G. D. Bean, A. Wang, B. Bohle, F. Golsaz Shirazi, K. Chakraborty, K. Tosh, T. Olsson, V. Bachanova, P. Lenert, C. J. Kirschning, N. Toyama-Sorimachi, M. Kimoto, S. Paessler, D. Yoo, S. J. Oh, C. Kitzmüller, M. Schmitz, D. Baltzis, K. Ono, A. J. Karpala, L. Hamann, M. Matsumoto, J. Lou, Z. Kato, J. Tak, N. Amirmozzafari, A. T. Egunsola, L. HjerrildZeuthen, Y. Tsai, B. Löbel, D. Wang, M. V. Zeid-Kilani, E. Lien, H. E. Park, H. Liu, A. Kimura, L. Chang, N. Rashidi, N. Kondo, C. Ouyang, J. Wang, H. Fischer, E. K. Persson, M. Yadav, P. Tanthuvanit, J. K. Smith, S. Taki, N. J. Nilsen, V. Younesi, R. Mitamura, H. Jähnisch, I. Chinen, J. Chen, T. Kimura, E. Quivy, M. A. Farrar, N. Abdelmagid, P. Wongprompitak, H. Y. Kim, A H Zarnani, B. Uleng, O. Leo, R. W. Wong, H. Rabbani, Gizem Tincer, S. Bolliger, W. Huang, T. Miethke, D. Rodionov, L. Heslop, N. Makiuchi, O. Moussa, Y. Lee, S. Tanaka, M. S. Lee, M. Hashimoto, K. Takatsu, L. Tussey, H. Kitamura, M. Diez, C. Wang, J. Lum, J. Dutz, M. Puig, G. Robert, Y. Nagai, K. Masuko, S. Liu, W. Chen, M. Arjmand, Z. Dembic, C. Scheibenbogen, H. Weng, T. Matsunaga, Y. Maru, S. Daum, M. Ikutani, Y. Tang, M. Mosallaei, S. Ye, H. Husebye, H. Nikzamir, S. Bauer, E. Yang, Ismail Simsek, Y. Deng, H. Frøkiær, H. Kao, G. Weiss, A. L. Poussard, G. E. Etokebe, R. R. Schumann, H. H. Mu, I. Choi, S. Deifl, K. Masuda, M. Montero-Diaz, T. Kishimoto, M. Yao, U. Kavita, E. Latz, N. E. Yun, H. Ohnishi, C. Leng, J. Knezevic, Q. Yuan, L. Katoozian, S. Koizumi, Y. Aoyagi, A. M. Crespo, S. Takao, A. P. Makrigiannis, R. Wehner, D. Bitchev, P. Chong, S. Nuchprayoon, H. S. Koh, J. W. Lowenthal, S. Chiou, S. Watanabe, R. Zhong, M. Yoshizaki, G. P. Garlet, H. Poo, H. Geng, T. Böldicke, D. Torres, J. Khoshnoodi, H. Chen, U. McKeever, S. Miranda-Hernandez, S. Mutschlechner, J. Goeken, S. Umlauf, H. Tochio, B. Weaver, S. Delbauve, M. Yousefi, J. R. Ribeiro dos Reis, K. Fukudome, K. Harnesk, N. K. Yee, G. Rivell, Seda Yerlikaya, E. Lüdeking, J. Y. Kim, N. Tsuneyoshi, A. Chou, H. Li, G. Liu, H. Tsukamoto, X. Liu, A. Hise, N. Li, P. Cohen, Fuat Cem Yagci, E. Jaensson

Publikováno v: International Immunology. 22:i10-i22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43f89ec8f0ca2428c506fdcbc718c62a
https://doi.org/10.1093/intimm/dxq076

Recent developments in mathematical aspects of relativistic fluids.

Autor: Disconzi, Marcelo¹ (AUTHOR) marcelo.disconzi@vanderbilt.edu

Publikováno v: Living Reviews in Relativity. 10/25/2024, Vol. 27 Issue 1, p1-218. 218p.

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

Autor: Leandi Krüger, Brittany N. Bohinc, Cynthia D. Guy, Guanhua Xie, Marzena Swiderska-Syn, Erika Segear Johnson, Sally Kornbluth, T. De Almeida Pereira, Mariana Verdelho Machado, Kelly R. Lindblom, Anna Mae Diehl, Gregory A. Michelotti, Jérôme Boursier, Gamze Karaca

Publikováno v: Gut
Gut, BMJ Publishing Group, 2015, 64 (7), pp.1148-1157. ⟨10.1136/gutjnl-2014-307362⟩

International audience; OBJECTIVE: Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We recently reported that caspase-2 was pivotal fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19b8b9e765c8c448b92a2035ffcdc10
https://hal.archives-ouvertes.fr/hal-01392300