Zobrazeno 1 - 10
of 2 097
pro vyhledávání: '"R. Lewin"'
Autor:
David W. J. Griffin, Michael Dymock, Germaine Wong, C. Orla Morrissey, Sharon R. Lewin, Allen C. Cheng, Kirsten Howard, Julie A. Marsh, Kanta Subbarao, Michelle Hagenauer, Janine Roney, Anthony Cunningham, Tom Snelling, James H. McMahon
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Immunocompromised hosts (ICH) experience more breakthrough infections and worse clinical outcomes following infection with COVID-19 than immunocompetent people. Prophylactic monoclonal antibody therapies can be challenging to acce
Externí odkaz:
https://doaj.org/article/1be3382a6889486ca70a589275975189
Autor:
Chanaveerappa Bammigatti, Timothy F Platts-Mills, Ashish Bhalla, Harish Kumar, Matthew R Lewin, Surendra Kumar, Charles J Gerardo, Rebecca W Carter, Farshad M Shirazi, Suneetha D Kotehal, Peter D Akpunonu, Richard B Schwartz, Neeraj Manikath, Partha P Mukherjee, Thomas C Arnold, Brian J Wolk, Sophia S Sheikh, Dawn R Sollee, David J Vearrier, Samuel J Francis, Adiel Aizenberg, Madhu K Ravikumar, Sujoy Sarkar, Taylor Haston, Andrew Micciche, Suraj C Oomman, Jeffery L Owen, Brandi A Ritter, Stephen P Samuel
Publikováno v:
BMJ Global Health, Vol 9, Iss 10 (2024)
Introduction Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a nearly ubiquitous component of snake venoms. We conducted a phase II clin
Externí odkaz:
https://doaj.org/article/c2f65f034bc74026a8e5cd8f3ccaacfe
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT Understanding the molecular mechanisms governing microbial interactions is crucial for unraveling the complexities of microbial communities and their ecological impacts. Here, we employed a two-species model system comprising the oral bacter
Externí odkaz:
https://doaj.org/article/2ccbfcdc3e1e42da92b45396eaa97d8b
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Janna Jamal Eddine, Thomas A Angelovich, Jingling Zhou, Sarah J Byrnes, Carolin Tumpach, Nadia Saraya, Emily Chalmers, Rory A Shepherd, Abigail Tan, Stephanie Marinis, Paul R Gorry, Jacob D Estes, Bruce J Brew, Sharon R Lewin, Sushama Telwatte, Michael Roche, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012446 (2024)
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is subject to t
Externí odkaz:
https://doaj.org/article/a288983a01634826840f2cf6e23b2dd3
Autor:
George Taiaroa, Doris Chibo, Sophie Herman, Mona L. Taouk, Megan Gooey, Jodie D'Costa, Rizmina Sameer, Nicole Richards, Elaine Lee, Lydya Macksabo, Nasra Higgins, David J. Price, Soo Jen Low, Eike Steinig, Genevieve E. Martin, Michael A. Moso, Leon Caly, Jacqueline Prestedge, Christopher K. Fairley, Eric P.F. Chow, Marcus Y. Chen, Sebastian Duchene, Jane S. Hocking, Sharon R. Lewin, Deborah A. Williamson
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 47, Iss , Pp 101103- (2024)
Summary: Background: In Australia the incidence of HIV has declined steadily, yet sustained reduction of HIV transmission in this setting requires improved public health responses. As enhanced public health responses and prioritisation of resources m
Externí odkaz:
https://doaj.org/article/3fc2c314c672401ab197139c9f36b1ae
Autor:
Julia Ojeda-Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos, Rakesh Kumar, Ming-Dong Zhang, James F. A. Poulet, Patrik Ernfors, Gary R. Lewin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, incl
Externí odkaz:
https://doaj.org/article/ee91562559af4c1c81fde4fe01d88824
Autor:
Kasha P. Singh, Anchalee Avihingsanon, Jennifer M. Zerbato, Wei Zhao, Sabine Braat, Surekha Tennakoon, Ajantha Rhodes, Gail V. Matthews, Christopher K. Fairley, Joe Sasadeusz, Megan Crane, Jennifer Audsley, Sharon R. Lewin
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105054- (2024)
Summary: Background: In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microb
Externí odkaz:
https://doaj.org/article/118a4cf1f7454af0a836c04c8076cde0
Autor:
Simon Desiderio, Frederick Schwaller, Kevin Tartour, Kiran Padmanabhan, Gary R Lewin, Patrick Carroll, Frederic Marmigere
Publikováno v:
eLife, Vol 12 (2024)
Touch sensation is primarily encoded by mechanoreceptors, called low-threshold mechanoreceptors (LTMRs), with their cell bodies in the dorsal root ganglia. Because of their great diversity in terms of molecular signature, terminal endings morphology,
Externí odkaz:
https://doaj.org/article/da1d327696b44197b36fd041048c3725
Autor:
Leslie Hayden, James M Lightner, Stacy Strausborger, Teri J Franks, Nora L Watson, Michael R Lewin-Smith
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301868 (2024)
The role that inhaled particulate matter plays in the development of post-deployment lung disease among US service members deployed to Southwest Asia during the Global War on Terrorism has been difficult to define. There is a persistent gap in data a
Externí odkaz:
https://doaj.org/article/d84e0db73b9841d78ebd781bacd616c4