Zobrazeno 1 - 10
of 41
pro vyhledávání: '"R. Lane Brown"'
Autor:
R Lane Brown, Wei-Hong Xiong, James H Peters, Merve Tekmen-Clark, Iwona Strycharska-Orczyk, Brian T Reed, Catherine W Morgans, Robert M Duvoisin
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117615 (2015)
Transient receptor potential (TRP) channels constitute a large family of cation permeable ion channels that serve crucial functions in sensory systems by transducing environmental changes into cellular voltage and calcium signals. Within the retina,
Externí odkaz:
https://doaj.org/article/7add064f34cd427b94f557d7f9daafe9
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45387 (2012)
The visual pigment melanopsin is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina, where it is involved in non-image forming light responses including circadian photoentrainment, pupil constriction, su
Externí odkaz:
https://doaj.org/article/a789951bc84448a7bba7f3d10e8fcfc3
Autor:
Alireza Ghahari, Diego C. Fernandez, Alan C. Rupp, Preethi Somasundaram, Lihong Cui, Cindy M. Pinhal, Zhijian Wu, Samer Hattar, Phyllis R. Robinson, Melissa E S Richardson, Tudor C. Badea, Glenn R. Wyrick, R. Lane Brown
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2741-2746
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and mediate several non-image-forming visual functions, including circadian photoentrainment and the pupillary light reflex (PLR). ipRGCs act as autonomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b7ef7c62157962c216a09ebcf95d37
https://doi.org/10.1073/pnas.1611893114
https://doi.org/10.1073/pnas.1611893114
Autor:
Robert M. Duvoisin, Brian T. Reed, R. Lane Brown, Wei Hong Xiong, Neal S. Burke, Catherine W. Morgans
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:1367-1373
Administration of voriconazole, an antifungal triazole, causes transient visual disturbances in patients and attenuates the b-wave of the ERG. We sought to identify the retinal target of voriconazole underlying the effect on the ERG b-wave.Electroret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ebe9c7be581e8dadb56cfd47ecfbe1
https://doi.org/10.1167/iovs.14-15270
https://doi.org/10.1167/iovs.14-15270
Publikováno v:
Channels
Photoreceptor cyclic nucleotide-gated (CNG) channels are the principal ion channels responsible for transduction of the light-induced change in cGMP concentration into an electrical signal. The ligand sensitivity of photoreceptor CNG channels is subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb34a506c877cba01fd3d184062f484
https://doi.org/10.4161/chan.20904
https://doi.org/10.4161/chan.20904
Publikováno v:
Biochemical Journal. 441:685-696
Mutations that perturb the function of photoreceptor CNG (cyclic nucleotide-gated) channels are associated with several human retinal disorders, but the molecular and cellular mechanisms leading to photoreceptor dysfunction and degeneration remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0488d71f9ed28cb67266d3a1609029a3
https://doi.org/10.1042/bj20111004
https://doi.org/10.1042/bj20111004
Publikováno v:
Cellular and Molecular Life Sciences. 69:1551-1562
Melanopsin-based phototransduction is involved in non-image forming light responses including circadian entrainment, pupil constriction, suppression of pineal melatonin synthesis, and direct photic regulation of sleep in vertebrates. Given that the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c80a654962fe5402b685d12fcf72cd
https://doi.org/10.1007/s00018-011-0891-3
https://doi.org/10.1007/s00018-011-0891-3
Autor:
Robert M. Duvoisin, Steve M. Nelson, Brett G. Jeffrey, R. Lane Brown, J. Zhang, Neal S. Burke, Catherine W. Morgans
Publikováno v:
Proceedings of the National Academy of Sciences. 106:19174-19178
The ON pathway of the visual system, which detects increases in light intensity, is established at the first retinal synapse between photoreceptors and ON-bipolar cells. Photoreceptors hyperpolarize in response to light and reduce the rate of glutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a18bc5a6d47bd525e40c7ff43ad3821
https://doi.org/10.1073/pnas.0908711106
https://doi.org/10.1073/pnas.0908711106
Publikováno v:
European Journal of Neuroscience. 29:359-367
In mammals, the neuronal pathways by which rod and cone photoreceptors mediate vision have been well documented. The roles that classical photoreceptors play in photoentrainment, however, have been less clear. In mammals, intrinsically photosensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62adbdef742ee653b8e757d425834f7
https://doi.org/10.1111/j.1460-9568.2008.06589.x
https://doi.org/10.1111/j.1460-9568.2008.06589.x
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:1034-1042
Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction by retinal photoreceptors and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdce9ef669b5ecd4c61237c8cd84230
https://doi.org/10.1107/s0907444908023512
https://doi.org/10.1107/s0907444908023512