Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R. Lakshman Chelvarajan"'
Autor:
Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i
Externí odkaz:
https://doaj.org/article/137463cd821e4008999c8df2193823b3
Autor:
Sanjay Sarkar, Ernest Bailey, Yun Young Go, R Frank Cook, Ted Kalbfleisch, John Eberth, R Lakshman Chelvarajan, Kathleen M Shuck, Sergey Artiushin, Peter J Timoney, Udeni B R Balasuriya
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006467 (2016)
Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of horses and other equid species. Following natural infection, 10-70% of the infected stallions can become persist
Externí odkaz:
https://doaj.org/article/826db0c3208140fa92533cfc51671b5c
Autor:
Subbarao Bondada, C. Darrell Jennings, Aubrey L. Frantz, Charlotte S. Kaetzel, Maria E. C. Bruno, Eric Rogier, Donald A. Cohen, R. Lakshman Chelvarajan, J. Anthony Brandon, Halide Tuna
Publikováno v:
Inflammatory Bowel Diseases. 18:2138-2148
Background: The pathogenesis of inflammatory bowel disease (IBD) is complex and the need to identify molecular biomarkers is critical. Epithelial cells play a central role in maintaining intestinal homeostasis. We previously identified five ‘‘sig
Autor:
Ted Kalbfleisch, Ernest Bailey, R. Frank Cook, Peter J. Timoney, Sanjay Sarkar, Udeni B. R. Balasuriya, Kathleen M. Shuck, R. Lakshman Chelvarajan, Yun Young Go, Sergey Artiushin, John E. Eberth
Publikováno v:
PLoS Genetics
PLOS Genetics
PLoS Genetics, Vol 12, Iss 12, p e1006467 (2016)
PLOS Genetics
PLoS Genetics, Vol 12, Iss 12, p e1006467 (2016)
Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of horses and other equid species. Following natural infection, 10–70% of the infected stallions can become persi
Publikováno v:
Mechanisms of Ageing and Development. 132:274-286
Age-associated defects in both B-lymphocytes and macrophages in elderly result in a reduction in the efficacy of vaccines to many Gram positive bacteria like Streptococcus pneumoniae. Splenic macrophages from aged mice have been shown to have a defec
Autor:
William D. Pierce, D. Allan Butterfield, Ciara Cini, Teresa Noel, Rukhsana Sultana, Jian Cai, Michael T. Tseng, Daret K. St. Clair, R. Lakshman Chelvarajan, Fabio Di Domenico, Subbarao Bondada
Publikováno v:
Journal of proteome research
9 (2010): 6232–6241. doi:10.1021/pr100465m
info:cnr-pdr/source/autori:Sultana, R (Sultana, Rukhsana)1,2,3; Di Domenico, F (Di Domenico, Fabio)4; Tseng, M (Tseng, Michael)5; Cai, JA (Cai, Jian)6; Noel, T (Noel, Teresa)7; Chelvarajan, RL (Chelvarajan, R. Lakshman); Pierce, WD (Pierce, William D.)6; Cini, C (Cini, Ciara)4; Bondada, S (Bondada, Subbarao)8; St Clair, DK (St Clair, Daret K.)7; Butterfield, DA (Butterfield, D. Allan)1,2,3/titolo:Doxorubicin-induced thymus senescence/doi:10.1021%2Fpr100465m/rivista:Journal of proteome research (Print)/anno:2010/pagina_da:6232/pagina_a:6241/intervallo_pagine:6232–6241/volume:9
9 (2010): 6232–6241. doi:10.1021/pr100465m
info:cnr-pdr/source/autori:Sultana, R (Sultana, Rukhsana)1,2,3; Di Domenico, F (Di Domenico, Fabio)4; Tseng, M (Tseng, Michael)5; Cai, JA (Cai, Jian)6; Noel, T (Noel, Teresa)7; Chelvarajan, RL (Chelvarajan, R. Lakshman); Pierce, WD (Pierce, William D.)6; Cini, C (Cini, Ciara)4; Bondada, S (Bondada, Subbarao)8; St Clair, DK (St Clair, Daret K.)7; Butterfield, DA (Butterfield, D. Allan)1,2,3/titolo:Doxorubicin-induced thymus senescence/doi:10.1021%2Fpr100465m/rivista:Journal of proteome research (Print)/anno:2010/pagina_da:6232/pagina_a:6241/intervallo_pagine:6232–6241/volume:9
Doxorubicin (DOX) is an anticancer drug used for the treatment of solid tumors. The ability of DOX to treat cancer is not specific to cancer cells; some of the cells that are normal may also become targets of DOX, thereby altering the normal cellular
Autor:
Pamela J. Henney, Peter J. Timoney, Shankar P. Mondal, Udeni B. R. Balasuriya, R. Frank Cook, R. Lakshman Chelvarajan
Publikováno v:
Archives of virology. 161(4)
Strains of equine arteritis virus (EAV) differ in their virulence phenotypes, causing anywhere from subclinical infections to severe disease in horses. Here, we describe the in silico design and de novo synthesis of a full-length infectious cDNA clon
Publikováno v:
Journal of Leukocyte Biology. 77:503-512
A reduction in macrophage (MΦ) function with aging makes mice less responsive to bacterial capsular polysaccharides, such as those present in the pneumococcal polysaccharide vaccine, a model of thymus independent (TI) antigen (Ag). Using trinitrophe
Publikováno v:
Immunologic Research. 31:25-36
The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors.
Autor:
Tanya Myers-Morales, Alan M. Kaplan, Annette Uittenbogaard, Amanda A. Gorman, Zhan Ye, Susan C. Straley, W. June Brickey, Jenny P.-Y. Ting, R. Lakshman Chelvarajan, Donald A. Cohen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i