Steroidal control of cell proliferation in the breast and breast cancer

Autor: R. L. Sutherland, E. A. Musgrove

Publikováno v: Progress in the Management of the Menopause ISBN: 9781003076575

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5609d7fb0792154d26dfb06bd4c76cf4
https://doi.org/10.1201/9781003076575-34

Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer

Autor: Susan J. Clark, Tennille Sibbritt, Wenjia Qu, Erik D Wiklund, Nicola J. Armstrong, Toby Hulf, Kate I. Patterson, Jenny Z. Song, Clare Stirzaker, Shalima S. Nair, James G. Kench, R. L. Sutherland, Lisa G. Horvath

Publikováno v: Hulf, T, Sibbritt, T, Wiklund, E D, Patterson, K, Song, J Z, Stirzaker, C, Qu, W, Nair, S, Horvath, L G, Armstrong, N J, Kench, J G, Sutherland, R L & Clark, S J 2013, ' Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer ', Oncogene, vol. 32, no. 23, pp. 2891-2899 . https://doi.org/10.1038/onc.2012.300

Deregulation of microRNA (miRNA) expression can have a critical role in carcinogenesis. Here we show in prostate cancer that miRNA-205 (miR-205) transcription is commonly repressed and the MIR-205 locus is hypermethylated. LOC642587, the MIR-205 host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df7881791606a9f96c4f1afd78b3756
https://doi.org/10.1038/onc.2012.300

Genomic analyses identify molecular subtypes of pancreatic cancer

Autor: J. Lynn Fink, Jeremy L. Humphris, Katia Nones, Robert Grützmann, Anirban Maitra, Paola Capelli, Peter J. Wilson, William E. Fisher, Aldo Scarpa, Christopher J. Scarlett, Richard A. Morgan, Ann-Marie Patch, Debabrata Mukhopadhyay, Murtaugh Lc, Oliver Hofmann, Marc Giry-Laterriere, Borislav Rusev, Jennifer P. Morton, Nicole Cloonan, David A. Wheeler, Anthony J. Gill, Krishna Epari, Nam Q. Nguyen, Amber L. Johns, James G. Kench, Saadia A. Karim, Lorena Pantano, Craig Nourse, Nigel B. Jamieson, Ivon Harliwong, Stephen H. Kazakoff, Darrin Taylor, Felicity Newell, Christian Pilarsky, Giampaolo Tortora, Shivangi Wani, Nicola Waddell, Mark J. Cowley, Jaswinder S. Samra, Scott Wood, Munzy Dm, Conrad Leonard, Laura Mincarelli, Suzanne Manning, Timothy J. C. Bruxner, Mark Pinese, Michael C.J. Quinn, Hair J, Andreia V. Pinho, R. L. Sutherland, Amanda Mawson, Neil D. Merrett, Andrew Barbour, Rita T. Lawlor, Jones, Corbo, Ilse Rooman, Lorraine A. Chantrill, Marie-Claude Gingras, Christopher W. Toon, Senel Idrisoglu, Emily S. Humphrey, Kelly Quek, Sean M. Grimmond, Christopher L. Wolfgang, Oliver Holmes, Andrew V. Biankin, Fraser Duthie, Qinying Xu, Kim Moran-Jones, Gloria M. Petersen, Lisa Evers, Peter Bailey, Elizabeth A. Musgrove, Alan J. Robertson, Marina Pajic, Emily K. Colvin, John V. Pearson, Nikolajs Zeps, David K. Chang, Karin S. Kassahn, David Miller, Janet Graham, Ehsan Nourbakhsh, Ralph H. Hruban, Luis Navarro Sanchez, Ulla-Maja Bailey, Chin, Jessica A. Lovell, Angelika N. Christ, Richard A. Gibbs, Eshleman, Karin A. Oien, Christine A. Iacobuzio-Donahue, Claudio Bassi, Adnan Nagrial, Matthew J. Anderson, Owen J. Sansom, Angela Chou, Roberto Salvia, Jianmin Wu

Publikováno v: Nature. 531(7592)

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da84f5bbe8c825ef3b1682554a8e729b
https://pubmed.ncbi.nlm.nih.gov/26977785

Abstract S6-8: Hedgehog Ligand Overexpression Predicts Poor Outcome in Breast Cancer and Is a Potential Therapeutic Target for Metastatic Disease

Autor: Robert F. Shearer, R. L. Sutherland, Sandra A O'Toole, DN Watkins, Dorothy A Machalek, Duncan J. Mcleod, M Ru Qiu, Alexander Swarbrick, Caroline L. Cooper, Eka Millar, Luciano G. Martelotto, Radhika Nair

Publikováno v: Cancer Research. 70:S6-8

Background: The Hh signalling pathway plays an important role in a number of malignancies, and accumulating data suggest it contributes significantly to the development and progression of breast cancer. However, there is scant data regarding the clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c83fdd5bf7a81b191fd61b6ecd25811
https://doi.org/10.1158/0008-5472.sabcs10-s6-8

Expression of the androgen receptor and an androgen-responsive protein, apolipoprotein D, in human breast cancer

Autor: Wayne D. Tilley, James O. Aspinall, Jacqueline M. Bentel, R. L. Sutherland, Stephen N. Birrell, R. E. Hall, David J. Horsfall

Publikováno v: British Journal of Cancer

Little is known regarding the activity and function of the androgen receptor (AR) in human breast cancer. In the present study AR was evaluated in untreated primary breast cancers using antisera to the amino- and carboxy-termini of the receptor and q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118fc5b31db2e718daea33d43c582d4d
https://doi.org/10.1038/bjc.1996.513