Zobrazeno 1 - 10
of 431
pro vyhledávání: '"R. L. Krauth-Siegel"'
Autor:
Maria Paz Clares, Francisco Olmo, Mario Inclán, R. L. Krauth-Siegel, Clotilde Marín, Kristína Urbanová, Conxa Soriano, Enrique García-España, María José Rosales, Roberto Tejero, Jorge González, Manuel Sánchez-Moreno
Publikováno v:
RSC Adv.. 4:65108-65120
The anti-chagasic activity of a series of eleven derivatives of aza-scorpiand-like macrocycles, some of them newly synthesised, was assayed. The four compounds with the best selectivity indices in vitro were subjected to in vivo assays. Tests in a mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f05b9e8d458298a6a176974f2287b9
https://doi.org/10.1039/c4ra09866h
https://doi.org/10.1039/c4ra09866h
Autor:
Julia Bader, Luiz E. Martinez, Enrique I. Ramos, R. L. Krauth-Siegel, Rosa A. Maldonado, Kristine M. Garza
Publikováno v:
Journal of Parasitology. 95:461-466
Chagas disease, caused by Trypanosoma cruzi, is a widespread infection in Latin America. Currently, only 2 partially effective and highly toxic drugs, i.e., benznidazole and nifurtimox, are available for the treatment of this disease, and several eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a194819292980dcafab9c457270ca0
https://doi.org/10.1645/ge-1686.1
https://doi.org/10.1645/ge-1686.1
Autor:
Alan H. Fairlamb, R. L. Krauth-Siegel, S. Krieger, Mark R. Ariyanayagam, Christine Clayton, W. Schwarz
Publikováno v:
Molecular Microbiology. 35:542-552
In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an intracellular reducing environment, substituting for the glutathione–glutathione reductase system found in most other organisms. To investigate the physiological role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c2e39f403312c71ac035db3fbdf6871
https://doi.org/10.1046/j.1365-2958.2000.01721.x
https://doi.org/10.1046/j.1365-2958.2000.01721.x
Publikováno v:
Journal of Medicinal Chemistry. 43:4812-4821
(2,2':6',2"-terpyridine)platinum(II) complexes possess pronounced cytostatic activities against trypanosomes and leishmania. As shown here, the complexes are irreversible inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d88b321228073a82ab1a02ef1e32cc1
https://doi.org/10.1021/jm000219o
https://doi.org/10.1021/jm000219o
Publikováno v:
Journal of Medicinal Chemistry. 39:1549-1554
A series of newly synthesized N10-arylisoalloxazinessome of which are known to be antimalarial agentswere studied as inhibitors of human glutathione reductase (GR; NADPH + GSSG + H+ ⇌ NADP+ + 2GSH)...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6512233b5fb153e6644d13b0c3cd8450
https://doi.org/10.1021/jm950511+
https://doi.org/10.1021/jm950511+
Autor:
R Schöneck, R L Krauth-Siegel
Publikováno v:
The FASEB Journal. 9:1138-1146
Trypanothione reductase (TR) is a flavoenzyme that has been found only in parasitic protozoa of the order Kinetoplastida. The enzyme catalyzes the NADPH-dependent reduction of glutathionylspermidine conjugates and is a key enzyme of the parasite's th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa801a2eab5b18af5f3ba92d7ea68deb
https://doi.org/10.1096/fasebj.9.12.7672506
https://doi.org/10.1096/fasebj.9.12.7672506
Autor:
Thomas Efferth, R L Krauth-Siegel, Tolga Eichhorn, Rolf Mertens, B Hahn, Wolf-Dieter Lehmann, A Wendler, S Schloissnig
Publikováno v:
Molecular bioSystems. 8(4)
Determining interacting cellular partners of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe profiling and compound-centric chemical proteomics. The anti-malarial artemisinin also exerts pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30683876e435462dd30c6b6aa9b717a
https://pubmed.ncbi.nlm.nih.gov/22311186
https://pubmed.ncbi.nlm.nih.gov/22311186
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd7711e579098f5fcc0c9a81689094ac
https://doi.org/10.1002/chin.199525320
https://doi.org/10.1002/chin.199525320
Publikováno v:
Biological chemistry. 384(4)
The bis(glutathionyl)spermidine trypanothione exclusively occurs in parasitic protozoa of the order Kine-toplastida, such as trypanosomes and leishmania, some of which are the causative agents of several tropical diseases. The dithiol is kept reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88710b633db4d2567e3a78e4553bc57
https://pubmed.ncbi.nlm.nih.gov/12751784
https://pubmed.ncbi.nlm.nih.gov/12751784
Publikováno v:
Revista Argentina de microbiologia. 32(3)
Dihydrolipoamide dehydrogenase (LADH) from Trypanosoma cruzi, the causative agent of Chagas' disease, was inactivated by treatment with myeloperoxidase (MPO)-dependent systems. LADH lipoamide reductase and diaphorase activities decreased as a functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fe60051b74fecbf67bcb1628bfd691c
https://pubmed.ncbi.nlm.nih.gov/11008705
https://pubmed.ncbi.nlm.nih.gov/11008705