Výsledky vyhledávání - "R. L. Kodell"

Interaction between two carcinogens in the two-stage clonal expansion model of carcinogenesis

Autor: D Krewski, J M Zielinski, R L Kodell

Publikováno v: Journal of epidemiology and biostatistics. 6(2)

BACKGROUND Exposure to two or more carcinogens may result in interactive effects in which the joint effect may be greater or less than that expected to arise as the sum of the effects of the two agents alone. In this article, we investigate the joint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54eb9af2ef34537f732ec9f84dfd893
https://pubmed.ncbi.nlm.nih.gov/11434501

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A comparison of methods of benchmark-dose estimation for continuous response data

Autor: R W, West, R L, Kodell

Publikováno v: Risk analysis : an official publication of the Society for Risk Analysis. 19(3)

Methods of quantitative risk assessment for toxic responses that are measured on a continuous scale are not well established. Although risk-assessment procedures that attempt to utilize the quantitative information in such data have been proposed, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74c03c17f9e5f72fa630d2b6a8c7bf07
https://pubmed.ncbi.nlm.nih.gov/10765417

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A unified approach to risk assessment for cancer and noncancer endpoints based on benchmark doses and uncertainty/safety factors

Autor: D W, Gaylor, R L, Kodell, J J, Chen, D, Krewski

Publikováno v: Regulatory toxicology and pharmacology : RTP. 29(2 Pt 1)

A fundamental goal of toxicology is to determine safe levels of human exposure to toxic substances. In the absence of information to establish dose-response relationships at low exposure levels generally experienced by humans, high-dose to low-dose l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c049a506a4bac008d96bdfedfa44bbf5
https://pubmed.ncbi.nlm.nih.gov/10341145

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Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice

Autor: G L, Wolff, R L, Kodell, S R, Moore, C A, Cooney

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 12(11)

'Viable yellow' (Avy/a) mice are larger, obese, hyperinsulinemic, more susceptible to cancer, and, on average, shorter lived than their non-yellow siblings. They are epigenetic mosaics ranging from a yellow phenotype with maximum ectopic agouti overe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e74165a7908bf6e04173d664bb80048
https://pubmed.ncbi.nlm.nih.gov/9707167

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An age-adjusted trend test for the tumor incidence rate for multiple-sacrifice experiments

Autor: R L, Kodell, H, Ahn

Publikováno v: Biometrics. 53(4)

The nonparametric age-adjusted trend test for the tumor incidence rate proposed by Malani and Lu (1993, Communications in Statistics--Theory and Methods 22, 1557-1584) is modified in two ways to improve the size of the test. First, the tumor incidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4eb32cbad61ecf6d2cff902ff21fe2cd
https://pubmed.ncbi.nlm.nih.gov/9423261

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Analysis of trinomial responses from reproductive and developmental toxicity experiments

Autor: J J, Chen, R L, Kodell, R B, Howe, D W, Gaylor

Publikováno v: Biometrics. 47(3)

This paper presents a Dirichlet-trinomial distribution for modelling data obtained from reproductive and developmental studies. The common endpoints for the evaluation of reproductive and developmental toxic effects are the number of dead fetuses, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0384978fda36843d75ea5c08b0348343
https://pubmed.ncbi.nlm.nih.gov/1742429

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Comparative study of intracellular glutathione content in rat lymphocyte cultures treated with 2-mercaptoethanol and interleukin-2

Autor: A, Aidoo, L E, Lyn-Cook, S M, Morris, R L, Kodell, D A, Casciano

Publikováno v: Cell biology and toxicology. 7(3)

The level of intracellular glutathione (GSH) in mitogen-stimulated mouse lymphocytes is increased in the presence of 2-mercaptoethanol (2-ME), an enhancer of lymphocyte activation and proliferation. Since proliferation of lymphocytes in response to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6bd5a1831784e46defc56870261ae0
https://pubmed.ncbi.nlm.nih.gov/1933513

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Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data

Autor: R P Felton, R L Kodell

Publikováno v: Environmental Health Perspectives

The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study. The model successfully predicts liver tumor incidence for time points beyond ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25440048c6c95bc9930d2a593ae8e586
https://pubmed.ncbi.nlm.nih.gov/1935845

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