Výsledky vyhledávání - "R. L. Erikson"

Reconstitution of the Raf-1-MEK-ERK Signal Transduction Pathway In Vitro

Autor: S. G. Macdonald, J. Driller, Frank McCormick, R Clark, Craig M. Crews, Lelia Wu, R. L. Erikson

Publikováno v: Molecular and Cellular Biology. 13:6615-6620

Raf-1 is a serine/threonine kinase which is essential in cell growth and differentiation. Tyrosine kinase oncogenes and receptors and p21ras can activate Raf-1, and recent studies have suggested that Raf-1 functions upstream of MEK (MAP/ERK kinase),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046b7a2ca0c92cfef54c2ffc05a62479
https://doi.org/10.1128/mcb.13.11.6615-6620.1993

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Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells

Autor: D R, Welch, T, Sakamaki, R, Pioquinto, T O, Leonard, S F, Goldberg, Q, Hon, R L, Erikson, M, Rieber, M S, Rieber, D J, Hicks, J V, Bonventre, A, Alessandrini

Publikováno v: Cancer research. 60(6)

Cellular growth and differentiation are controlled by multiple extracellular signals, many of which activate extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAP) kinases. Components of the MAP kinase pathways also cause oncogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::583b2fe4981b31e0b7ec5dc03048a6d6
https://pubmed.ncbi.nlm.nih.gov/10749122

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Differential expression of MEK1 and MEK2 during mouse development

Autor: A, Alessandrini, B K, Brott, R L, Erikson

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(5)

Map/Erk kinase 1 (MEK1) and MEK2 activate the Erk/ MAP kinases and have been implicated in cell growth and differentiation. To investigate the role of MEKs during mouse development, we have examined their expression and activity in various murine tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d576d3a59b82001d04db784d8815805b
https://pubmed.ncbi.nlm.nih.gov/9149902

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MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues

Autor: B K, Brott, A, Alessandrini, D A, Largaespada, N G, Copeland, N A, Jenkins, C M, Crews, R L, Erikson

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 4(11)

MEK1 is a dual specificity kinase that phosphorylates and activates the Erk/MAP kinases Erk-1 and Erk-2 by phosphorylating them on threonine and tyrosine. We report the cloning of a second MEK-like complementary DNA, Mek2, which predicts a protein of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8efb5135fb6461ee0acaab457bd28ed5
https://pubmed.ncbi.nlm.nih.gov/8297798

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Protein tyrosine phosphatase 1B undergoes mitosis-specific phosphorylation on serine

Autor: A R, Schievella, L A, Paige, K A, Johnson, D E, Hill, R L, Erikson

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 4(4)

We have investigated the regulation of protein tyrosine phosphatase 1B (PTP1B) through the cell cycle of HeLa cells. PTP1B from HeLa cells arrested in mitosis migrated more slowly during sodium dodecyl sulfate-polyacrylamide gel electrophoresis than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cce70c07dab7d49c3531a98569c2276e
https://pubmed.ncbi.nlm.nih.gov/8494789

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Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis

Autor: J, Blenis, J, Chung, E, Erikson, D A, Alcorta, R L, Erikson

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 2(6)

Previous studies demonstrated that addition of protein synthesis inhibitors to quiescent cells resulted in the stimulation of S6 kinase activity. The present characterization of several growth factor- and oncogene-regulated protein-serine/threonine k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c45de8e6e5d936787c9045a5b3e84be
https://pubmed.ncbi.nlm.nih.gov/1648378

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