Zobrazeno 1 - 9
of 9
pro vyhledávání: '"R. L. Desjarlais"'
Autor:
J. Briand, David G. Tew, W.W. Smith, I. E. James, L. Lee-Rykaczewski, D. Zymbryki, Sherin S. Abdel-Meguid, Dennis S. Yamashita, Michael S. McQueney, Thaddeus A. Tomaszek, H.-J. Oh, Robert W. Marquis, S. A. Carr, S. M. Halbert, Scott K. Thompson, T. J. Carr, R. L. Desjarlais, Mary J. Bossard, C. A. Janson, M. A. LevyJr., Daniel F. Veber, Karla J. D'Alessio, John G. Gleason, Ru Yu, B. Zhao
Publikováno v:
Peptide Science — Present and Future ISBN: 9780792352716
D.F. VEBER, R.W. MARQUIS, Y. RU, D.S. YAMASHITA, H.-J. OH, S.K. THOMPSON, S.M. HALBERT, T.J. CARR, J.G. GLEASON, T.A. TOMASZEK, JR. M.A. LEVY, M. BOSSARD, D.G. TEW, I.E. JAMES, J. BRIAND, S.A. CARR, D. ZYMBRYKI, L. LEE-RYKACZEWSKI, R.L. DESJARLAIS, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4f8585b3d843c232031d7ef5458207
https://doi.org/10.1007/0-306-46864-6_211
https://doi.org/10.1007/0-306-46864-6_211
Autor:
S S, Abdel-Meguid, B W, Metcalf, T J, Carr, P, Demarsh, R L, DesJarlais, S, Fisher, D W, Green, L, Ivanoff, D M, Lambert, K H, Murthy
Publikováno v:
Biochemistry. 33(39)
(2R,4S,5S,1'S)-2-Phenylmethyl-4-hydroxy-5-(tert-butoxycarbonyl) amino-6-phenylhexanoyl-N-(1'-imidazo-2-yl)-2'-methylpropanamide (compound 2) is a tripeptide analogue inhibitor of HIV-1 protease in which a C-terminal imidazole substituent constitutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57195bad210ce7eddd3833927d7b2c43
https://pubmed.ncbi.nlm.nih.gov/7918383
https://pubmed.ncbi.nlm.nih.gov/7918383
Autor:
S K, Thompson, K H, Murthy, B, Zhao, E, Winborne, D W, Green, S M, Fisher, R L, DesJarlais, T A, Tomaszek, T D, Meek, J G, Gleason
Publikováno v:
Journal of medicinal chemistry. 37(19)
The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810ff4ecab5086a77f59bc6f9906ada9
https://pubmed.ncbi.nlm.nih.gov/7932533
https://pubmed.ncbi.nlm.nih.gov/7932533
Autor:
S S, Abdel-Meguid, B, Zhao, K H, Murthy, E, Winborne, J K, Choi, R L, DesJarlais, M D, Minnich, J S, Culp, C, Debouck, T A, Tomaszek
Publikováno v:
Biochemistry. 32(31)
The human immunodeficiency virus type 1 (HIV-1) protease is a potential target of acquired immune deficiency syndrome (AIDS) therapy. A highly potent, perfectly symmetrical phosphinate inhibitor of this enzyme, SB204144, has been synthesized. It is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977ff3a265eaf6a31672893596b3b42f
https://pubmed.ncbi.nlm.nih.gov/8347601
https://pubmed.ncbi.nlm.nih.gov/8347601
Autor:
G L Seibel, R. L. Desjarlais, Juan C. Alvarez, Paul S. Furth, Lilia M. Babé, P R Ortiz de Montellano, D. L. Decamp, Charles S. Craik, Irwin D. Kuntz
By using a structure-based computer-assisted search, we have found a butyrophenone derivative that is a selective inhibitor of the human immunodeficiency virus 1 (HIV-1) protease. The computer program creates a negative image of the active site cavit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b74a4c7f7a57c1c9b75e6e85fe80488
https://europepmc.org/articles/PMC54593/
https://europepmc.org/articles/PMC54593/
Publikováno v:
Anti-cancer drug design. 5(3)
Using a general shape-search docking algorithm, potential DNA minor groove binding compounds were selected from a subset from the Cambridge Crystallographic Database consisting of almost 10,000 molecules. The crystal structure of the DNA dodecamer as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf1eba729f9b8c616fb176d5e960f187
https://pubmed.ncbi.nlm.nih.gov/2169249
https://pubmed.ncbi.nlm.nih.gov/2169249
Publikováno v:
Journal of Medicinal Chemistry. 31:722-729
Finding novel leads from which to design drug molecules has traditionally been a matter of screening and serendipity. We present a method for finding a wide assortment of chemical structures that are complementary to the shape of a macromoleculer rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e4476aa8e58db53d4c132ed427a16
https://doi.org/10.1021/jm00399a006
https://doi.org/10.1021/jm00399a006
Publikováno v:
Journal of medicinal chemistry. 29(11)
We present a method to explore the interaction of flexible ligands with receptors of known geometry on the basis of molecular shape. This method is an extension of that described by Kuntz et al. (J. Mol. Biol. 1982, 161, 269). The shape of a binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a07284f6c0b1de91ab12d04f1db93c
https://pubmed.ncbi.nlm.nih.gov/3783576
https://pubmed.ncbi.nlm.nih.gov/3783576
Publikováno v:
ChemInform. 18
We present a method to explore the interaction of flexible ligands with receptors of known geometry on the basis of molecular shape. This method is an extension of that described by Kuntz et al. (J. Mol. Biol. 1982, 161, 269). The shape of a binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c94953eeb99f2f3600baf9296671506
https://doi.org/10.1002/chin.198715377
https://doi.org/10.1002/chin.198715377