Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R. L. Berens"'
Publikováno v:
Journal of Biological Chemistry. 269:28979-28987
Drug resistance is a significant impediment to the therapy of African sleeping sickness in humans. To evaluate molecular mechanisms that contribute to drug resistance in African trypanosomes, a clonal strain of Trypanosoma brucei gambiense, MPA10, wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3945f5dda734938e21a7ef002b69dafd
https://doi.org/10.1016/s0021-9258(19)62002-8
https://doi.org/10.1016/s0021-9258(19)62002-8
Publikováno v:
The Journal of Immunology. 151:2024-2031
Infection with Toxoplasma gondii is an important cause of morbidity and mortality throughout the world. In immunocompetent hosts, the infection is usually not significant. However, infection occurring in neonates or other individuals with defective c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576c6beab2a38e45dc815ebe2d93546d
https://doi.org/10.4049/jimmunol.151.4.2024
https://doi.org/10.4049/jimmunol.151.4.2024
Publikováno v:
Biochemical pharmacology. 42(2)
Two nucleosides related to the known antiprotozoal agent 1-(beta-D-ribofuranosyl)-1,5-dihydro-4H-pyrazolo-[3,4-d]pyrimidine-4-one (allopurinol riboside, 1) were prepared and evaluated against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b07105c44de42de0d4328927c171d1b4
https://pubmed.ncbi.nlm.nih.gov/1859443
https://pubmed.ncbi.nlm.nih.gov/1859443
Autor:
I. A. Elegbe, R. S. Klein, P P McCann, Cyrus J. Bacchi, K. V. B. Rao, R. L. Berens, J. J. Marr, H C Nathan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 31:1406-1413
Kinetoplastid hemoflagellates are sensitive to growth inhibition by various purine analogs. In this study the activities of 9-deazainosine (9-DINO), formycin B, and sinefungin were compared in experimental murine Trypanosoma brucei subsp. brucei infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47036f7d8cd98a9d5ceb1c04371bd39
https://doi.org/10.1128/aac.31.9.1406
https://doi.org/10.1128/aac.31.9.1406
Publikováno v:
Biochemical pharmacology. 31(2)
Thiopurinol [4-thiopyrazolo(3.4-dyprimidine, TPP] and its ribonucleoside (TPPR) were effective in vitro against the intracellular and extracellular forms of L. braziliensis and L. mexicana. They also inhibited the transformation of the amastigote of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::405c1c1ed600763ea16020a8efdd6487
https://pubmed.ncbi.nlm.nih.gov/7073876
https://pubmed.ncbi.nlm.nih.gov/7073876
Publikováno v:
Advances in experimental medicine and biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fd69022ccdf647b14b3b147f4cef356
https://pubmed.ncbi.nlm.nih.gov/3766244
https://pubmed.ncbi.nlm.nih.gov/3766244
Publikováno v:
The Journal of parasitology. 69(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c4fb2bb6728d5a31f7cf69f404a825c
https://pubmed.ncbi.nlm.nih.gov/6338193
https://pubmed.ncbi.nlm.nih.gov/6338193
Publikováno v:
The Journal of biological chemistry. 259(8)
Four distinct nucleoside cleaving enzymes were detected in extracts of Trypanosoma cruzi epimastigotes. Two of these were nucleoside phosphorylases: one was specific for pyrimidines and the other for purines. The other two enzymes were nucleoside hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::690c742825f6ae8e94fd4e52ac984f3a
https://pubmed.ncbi.nlm.nih.gov/6425283
https://pubmed.ncbi.nlm.nih.gov/6425283
Publikováno v:
The Journal of biological chemistry. 261(20)
We investigated the antileishmanial actions of the pyrazolopyrimidines allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine), thiopurinol (4-thiopyrazolo[3,4-d]pyrimidine), and aminopurinol (4-aminopyrazolo[3,4-d]pyrimidine). These compounds affect severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e89a0f950cddae6719eb1620cff13b2
https://pubmed.ncbi.nlm.nih.gov/2424909
https://pubmed.ncbi.nlm.nih.gov/2424909
Autor:
D J, Nelson, S W, LaFon, J V, Tuttle, W H, Miller, R L, Miller, T A, Krenitsky, G B, Elion, R L, Berens, J J, Marr
Publikováno v:
The Journal of biological chemistry. 254(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc7020b5fd3bcf1eedaafb82bf8690a9
https://pubmed.ncbi.nlm.nih.gov/500658
https://pubmed.ncbi.nlm.nih.gov/500658