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Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by l-DOPA plus decarboxylase inhibition

Autor: R. Kuntzman, Allan H. Conney, Kazuo Nakamura, A. Maggio

Publikováno v: Neuropharmacology. 12:1153-1160

The bilateral administration of 6-hydroxydopamine into the caudatus-putamen areas of the rat decreased the analgesia produced by morphine and the brain's content of dopamine in a dose-dependent fashion and increased morphine-induced catalepsy. The ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611dcfecdab49fe450cd1e4adbf4fe4c
https://doi.org/10.1016/0028-3908(73)90072-5

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Assay and partial purification of epoxide hydrase from rat liver microsomes

Autor: A.H. Conney, Patrick M. Dansette, Haruhiko Yagi, Donald M. Jerina, John W. Daly, A.Y.H. Lu, W. Levin, R. Kuntzman

Publikováno v: Archives of Biochemistry and Biophysics. 164:511-517

Solubilized cytochrome P-450 monooxygenase and epoxide hydrase activities from rat liver microsomes have been separated by column chromatography. The highly active epoxide hydrase fraction is still contaminated with cytochrome P-450, which has very l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89f40f7184f8a2faa04d25ebdc3f741
https://doi.org/10.1016/0003-9861(74)90061-7

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Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates

Autor: R. Kuntzman, Anthony Y. H. Lu, Wayne Levin

Publikováno v: Biochemical and Biophysical Research Communications. 60:266-272

The resolved liver microsomal hydroxylation system required lipid for benzphetamine N-demethylation. Certain nonionic detergents, such as Emulgen 911, Triton N-101, and Triton X-100, at appropriate concentrations could substitute for lipid. These res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43a8d6a0000683cbf19359c030466927
https://doi.org/10.1016/0006-291x(74)90200-9

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Biphasic Decrease of Radioactive Hemoprotein from Liver Microsomal CO-binding Particles

Autor: W Levin, R Kuntzman

Publikováno v: Journal of Biological Chemistry. 244:3671-3676

The administration of δ-aminolevulinic acid-3,5-3H to immature male rats leads to the incorporation of radioactivity into the hemoprotein contained in the "CO-binding particles" (steapsin-treated microsomes which do not contain cytochrome b5). A bip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88e56dcadf7ed7c20bc2cd7d63960661
https://doi.org/10.1016/s0021-9258(18)83421-4

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