Zobrazeno 1 - 10
of 132
pro vyhledávání: '"R. Krulik"'
Publikováno v:
Neuroscience Letters. 197:49-52
The peptidergic innervation of the pineal gland contains arginine vasopressin (AVP) fibers. Since the site and molecular mechanism of AVP action on the pineal signal transduction has not yet been determined, we examined whether the inositol phosphate
Publikováno v:
General physiology and biophysics. 15(1)
The relations between the concentrations of a drug in the blood (plasma, haemoglobin, red blood cells (RBCs), RBC membranes) and in the brain tissue (homogenate, membranes, cytosol) were investigated during chronic administration of imipramine. Radio
Publikováno v:
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 29(12)
In an attempt to establish a radioimmunoassay (RIA), imipramine and amitriptyline immunogens were prepared; desmethyl derivatives were converted into hemisuccinates, conjugated with bovine serum albumin and used for rabbit immunization. [3H]Amitripty
Publikováno v:
Acta cardiologica. 46(3)
Publikováno v:
Drug Metabolism and Drug Interactions. 9
Phosphorylation of synaptic plasma brain membranes (SPM) causes a decrease of the specific binding of demethylated tricyclic antidepressants (TCA) and changes the affinity of 3H-imipramine and 3H-desmethylimipramine binding. The decrease of TCA bindi
Publikováno v:
Drug metabolism and drug interactions. 9(3-4)
We studied the binding of methylated and demethylated tricyclic antidepressants (TCA) to synaptic plasma brain membranes (SPM) and to lymphocyte, platelet and erythrocyte membranes. In the synaptic plasma membranes, more demethylated than methylated
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:170
Publikováno v:
Journal of Molecular and Cellular Cardiology. 22:S26
Publikováno v:
European Journal of Pharmacology. 149:357-361
The binding of [3H]imipramine, its 2- and 4-nitroderivatives and [3H]desmethylimipramine to lymphocyte membranes was determined. IC50 values for drugs and neurotransmitters to inhibit [3H]imipramine binding to lymphocyte membranes were comparable wit
Autor:
R. Krulik, Milan Černý
Publikováno v:
Life Sciences. 10:145-151
It is known that stress is accompanied by an increased level of corticosteroids in the blood. If tranquilizers are administered prior to stress, then according to some authors the production of 17-hydroxycorticosteroids by adrenal is decreased /1/. K