Zobrazeno 1 - 10
of 1 244
pro vyhledávání: '"R. Kreutz"'
Autor:
M. Sanz-Gómez, F.J. Manzano-Lista, E. Vega-Martín, D. González-Moreno, M. Alcalá, M. Gil-Ortega, B. Somoza, C. Pizzamiglio, L.M. Ruilope, I. Aránguez, P. Kolkhof, R. Kreutz, M.S. Fernández-Alfonso
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115661- (2023)
The non-steroidal mineralocorticoid receptor antagonist (MRA) finerenone (FIN) improves kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) in type 2 diabetes (T2D). We explored the effect of FIN in a novel model of type
Externí odkaz:
https://doaj.org/article/587d3d659d0b4bd4b2787136fc4a2583
Autor:
Mary Muhia, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, Petra Breiden, Yvonne Pechmann, Michael R. Kreutz, Matthias Kneussel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.
Externí odkaz:
https://doaj.org/article/2a57e15d62354e63a3239b6cceda15bf
Autor:
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It ha
Externí odkaz:
https://doaj.org/article/8050b454059242799298a70205d8078a
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiological tasks
Externí odkaz:
https://doaj.org/article/bbd43f596fb54ca9a8133a9e5ed0b10d
Autor:
Maria Andres-Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M. Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez-Rojas, Syed Ahsan Raza, Nicola Brice, Torben J. Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark Carlton, Antonio Virgilio Failla, Oliver Stork, Michaela Schweizer, Eckart D. Gundelfinger, Matthias Kneussel, Christina Spilker, Anna Karpova, Michael R. Kreutz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plas
Externí odkaz:
https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec8
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The role of sleep for brain function has been in the focus of interest for many years. It is now firmly established that sleep and the corresponding brain activity is of central importance for memory consolidation. Less clear are the underlying molec
Externí odkaz:
https://doaj.org/article/9909f9a4ad37438e81249454e655a576
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene
Externí odkaz:
https://doaj.org/article/89f3917176054208a268f29737d840f6
Autor:
Michael Bucher, Stephan Niebling, Yuhao Han, Dmitry Molodenskiy, Fatemeh Hassani Nia, Hans-Jürgen Kreienkamp, Dmitri Svergun, Eunjoon Kim, Alla S Kostyukova, Michael R Kreutz, Marina Mikhaylova
Publikováno v:
eLife, Vol 10 (2021)
Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for
Externí odkaz:
https://doaj.org/article/ae5e4335b9ee493d9711cd6022768961
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Externí odkaz:
https://doaj.org/article/f366eaf2841b4523ba8f361c068d8b88
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The calmodulin (CaM)-like Ca2+-sensor proteins caldendrin, calneuron-1 and -2 are members of the neuronal calcium-binding protein (nCaBP)-family, a family that evolved relatively late during vertebrate evolution. All three proteins are abundant in br
Externí odkaz:
https://doaj.org/article/2adcdd3e47dc4215bfe4c118b225bbac