Výsledky vyhledávání - "R. Kownatzki"

Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations

Autor: R. Kownatzki, Heinfried H. Radeke, Uwe Christians, Hans-Martin Schiebel, Schottmann R, Karl-Fr. Sewing

Publikováno v: Clinical Biochemistry. 24:271-275

Metabolism of FK506, a 23 member macrolide under clinical investigation as immunosuppressant after transplantation, was studied using human liver microsomes. Two fractions isolated by semipreparative HPLC were identified by negative fast atom bombard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851c606c1cdc7f0883a8557acd5e54ea
https://doi.org/10.1016/0009-9120(91)80019-y

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Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes

Autor: Uwe Christians, R. Kownatzki, S. Strohmeyer, Hans-Martin Schiebel, Schottmann R, K F Sewing, Jörg S. Bleck, K. Kohlhaw

Publikováno v: Xenobiotica. 21:1199-1210

1. Cyclosporine and its metabolites, isolated from human bile and identified by FAB mass spectrometry and 1H-n.m.r. spectroscopy, were metabolized by human liver microsomes for the identification of new cyclosporine metabolites. From these data a met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316e6c17e9a49ac5a647c1c803b62c1e
https://doi.org/10.3109/00498259109039560

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Mechanical challenge causes alterations of rat colonic mucosa and released mucins. Alterations of mucosa and mucins

Autor: M L, Enss, U, Schmidt-Wittig, K, Höner, R, Kownatzki, K, Gärtner

Publikováno v: Journal of experimental animal science. 36(4-5)

The effect of intraluminal challenge on rat colonic mucin producing cells and the amount and composition of released mucins was investigated. Germfree rats (GF) were maintained on a commercial high fiber (HF) diet (37% of undigestable fiber, Altromin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5244df8b53ac599d9dd160804e65078d
https://pubmed.ncbi.nlm.nih.gov/7948064

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Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile--isolation of 12 new cyclosporine metabolites

Autor: K. Kohlhaw, Schottmann R, K F Sewing, J Greipel, Jörg S. Bleck, S. Strohmeyer, Uwe Christians, Hans-Martin Schiebel, R. Kownatzki

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 21(9)

1. Cyclosporine metabolites of known and unknown structures were isolated, by semi-preparative h.p.l.c., from human bile from the T-tube of liver-grafted patients, who received cyclosporine treatment. Their structures were elucidated by FAB mass spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2154907a5bc9d0486e6f95941dbb94c
https://pubmed.ncbi.nlm.nih.gov/1788987

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Measurement of FK 506 by HPLC and isolation and characterization of its metabolites

Autor: U, Christians, C, Kruse, R, Kownatzki, H M, Schiebel, R, Schwinzer, M, Sattler, R, Schottmann, A, Linck, V M, Almeida, F, Braun

Publikováno v: Transplantation proceedings. 23(1 Pt 2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03937f90dbe24e0cd53dd176f31e7011
https://pubmed.ncbi.nlm.nih.gov/1703358

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STUDIES ON NATURAL STONE MONUMENTS - METHODOLOGY AND EXAMPLES

Autor: Bernd Fitzner, R. Kownatzki

The method used in systematic studies to qualitatively and quantitatively record the weathered state of natural stone monuments, is presented. The on-site investigation includes mapping the lithology and the weathering forms of the stone used, as wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ef579cb63c548bf09ea2e8ed8d02639
https://doi.org/10.1016/b978-0-7506-0237-2.50170-2

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