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Complement dependent cytotoxicity (CDC) activity of a humanized anti Lewis-Y antibody: FACS-based assay versus the ‘classical’ radioactive method—Qualification, comparison and application of the FACS-based approach

Autor: R. Kircheis, Andreas Nechansky, N. Halanek, P. Siegl, Oliver Szolar, I. Zinoecker, S. Wiederkum

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 49:1014-1020

The fully humanized Lewis-Y carbohydrate specific monoclonal antibody (mAb) IGN311 is currently tested in a passive immunotherapy approach in a clinical phase I trail and therefore regulatory requirements demand qualified assays for product analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c9dbe6a7a0abf414fe630e5f2feeb2
https://doi.org/10.1016/j.jpba.2009.01.029

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Polycation-based DNA complexes for tumor-targeted gene delivery in vivo

Autor: R, Kircheis, S, Schüller, S, Brunner, M, Ogris, K H, Heider, W, Zauner, E, Wagner

Publikováno v: The journal of gene medicine. 1(2)

Efficient and target-specific in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc89e7780dba9d80123bb3c8436bf2d6
https://pubmed.ncbi.nlm.nih.gov/10738575

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Liposomes containing interferon-gamma as adjuvant in tumor cell vaccines

Autor: M L, van Slooten, G, Storm, A, Zoephel, Z, Küpcü, O, Boerman, D J, Crommelin, E, Wagner, R, Kircheis

Publikováno v: Pharmaceutical research. 17(1)

Liposomal systems may be useful as a cytokine supplement in tumor cell vaccines by providing a cytokine reservoir at the antigen presentation site. Here, we examined the effect of liposome incorporation of mIFNgamma on its potency as adjuvant in an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9cd383ac7fd292c7d5574c2d73dfe95b
https://pubmed.ncbi.nlm.nih.gov/10714607

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Sustained cytokine delivery for anticancer vaccination: liposomes as alternative for gene-transfected tumor cells

Autor: F J, Koppenhagen, Z, Küpcü, G, Wallner, D J, Crommelin, E, Wagner, G, Storm, R, Kircheis

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(8)

Vaccination with tumor cells genetically engineered to produce interleukin (IL)-2 is an attractive strategy to enhance antitumor immune responses. The improved antitumor immunity upon vaccination with IL-2 gene-modified tumor cells may be due to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::019b6fa10bedef7daf49c40e2ee85d66
https://pubmed.ncbi.nlm.nih.gov/9717815

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Cytokine gene-modified tumor cells for prophylactic and therapeutic vaccination: IL-2, IFN-gamma, or combination IL-2 + IFN-gamma

Autor: R, Kircheis, Z, Küpcü, G, Wallner, E, Wagner

Publikováno v: Cytokines, cellularmolecular therapy. 4(2)

Murine melanoma cells were engineered to express interleukin-2 (IL-2), interferon-gamma (IFN-gamma) or both cytokines at various dose levels by means of the adenovirus-enhanced transferrinfection (AVET) method. The gene-modified cells were tested for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b7b88cb4ef1086e735ef3e5ea4f4a73
https://pubmed.ncbi.nlm.nih.gov/9681248

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Selective lysis of early embryonic cells by the alternative pathway of complement--a possible mechanism for programmed cell death in embryogenesis

Autor: R, Kircheis, L, Kircheis, H, Oshima, C, Kohchi, G, Soma, D, Mizuno

Publikováno v: In vivo (Athens, Greece). 10(4)

Early embryonic cells and early mouse embryos were shown to activate the alternative pathway of complement, and to be highly sensitive to complement-mediated cytolysis (Kircheis et al, In Vivo 9: 85-98, 1995). Under further development embryonic cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79d13f8e476e8a144fab2f5473712715
https://pubmed.ncbi.nlm.nih.gov/8839785

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Early embryonic cells activate the alternative complement system

Autor: R, Kircheis, L, Kircheis, H, Oshima, C, Kohchi, G, Soma, D, Mizuno

Publikováno v: In vivo (Athens, Greece). 9(2)

Murine embryonic stem cells, embryonic carcinoma cells and pre-implantation embryos were found to be extremely sensitive to cytolysis by normal human serum as compared to matured cells. The cytolytic activity to embryonic cells was not removed by pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74a3694d45f3609891b4b0d1582bf990
https://pubmed.ncbi.nlm.nih.gov/7548794

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