Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. Kip Guy"'
Autor:
Janice L. Hyatt, Lyudmila Tsurkan, Charles R. Ross, Guy Crundwell, R. Kip Guy, Philip M. Potter, M. Jason Hatfield, Randy M. Wadkins, Stephanie A. Cantalupo, Mary K. Danks, Latorya D. Hicks, Carol C. Edwards
Publikováno v:
Journal of Medicinal Chemistry. 50:5727-5734
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of these proteins may prove useful in modulating drug half-life and bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08d60bf36bac6e900c1f9c6557cfee
https://doi.org/10.1021/jm0706867
https://doi.org/10.1021/jm0706867
Autor:
R. Kip Guy
Publikováno v:
Proceedings of the National Academy of Sciences. 97:7307-7312
Sonic hedgehog (Shh) is a signaling molecule that is important for defining patterning in the developing vertebrate central nervous system. After translation, Shh autoproteolyzes and covalently attaches cholesterol to the newly formed carboxyl termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e65eef7b7c4df81403985387492011
https://doi.org/10.1073/pnas.97.13.7307
https://doi.org/10.1073/pnas.97.13.7307
Publikováno v:
Nature Chemical Biology. 1:146-148
High-throughput screening (HTS) searches large libraries of chemical compounds for those that can modulate the activity of a particular biological target; it is the dominant technique used in early-stage drug discovery. A key problem in HTS is the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c647f5395f0d63c929cf0b1c894139d4
https://doi.org/10.1038/nchembio718
https://doi.org/10.1038/nchembio718
Autor:
Richard J. Gilbertson, Yogesh T. Patel, Clinton F. Stewart, Brandon Bianski, Birgit Nimmervoll, Michael DeCuypere, Anang A. Shelat, R. Kip Guy, Thomas E. Merchant
Publikováno v:
Neuro-Oncology. 18:iii144-iii144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960eb5f30855dd113c04f3d26bef6dce
https://doi.org/10.1093/neuonc/now080.22
https://doi.org/10.1093/neuonc/now080.22
Publikováno v:
Science Signaling. 2
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored a workshop, “Chemical Approaches to Nuclear Receptors and Metabolism,” in April 2009 to explore how chemical and molecular biology and physiology can be exploi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97442fadd7a2eb758651a8089aa20dd
https://doi.org/10.1126/scisignal.282mr5
https://doi.org/10.1126/scisignal.282mr5
Autor:
R. Kip Guy, P. Therese Lang, Irwin D. Kuntz, Irene Gomez‐Pinto, Thomas L. James, David Smithson
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e02592df22f7b8959e8daa5228d302
https://doi.org/10.1096/fasebj.20.4.a73-a
https://doi.org/10.1096/fasebj.20.4.a73-a
Autor:
R. Kip Guy
Publikováno v:
Current Opinion in Chemical Biology. 11:410-411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b9f357f3b108443fcdf8408f111cbf
https://doi.org/10.1016/j.cbpa.2007.06.417
https://doi.org/10.1016/j.cbpa.2007.06.417
Autor:
R Kip Guy, William E. Evans
Publikováno v:
Nature Genetics. 36:214-215
After establishing a pattern of gene expression that identifies a desired drug effect in leukemia cells (e.g., differentiation), post-treatment gene expression can be used to screen candidate compounds for their ability to induce the target phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8403bafbc268e83cc8929e4d522b902c
https://doi.org/10.1038/ng0304-214
https://doi.org/10.1038/ng0304-214
Autor:
Angel M. Carcaboso, Paul Gibson, R. Kip Guy, Robert A. Johnson, Clinton F. Stewart, Helen Poppleton, Yiai Tong, Tanya A. Kranenburg, Jennifer M. Atkinson, Anang A. Shelat, Kumarasamypet M. Mohankumar, Alexander Arnold, Karen Wright, Liqin Zhu, Timothy N. Phoenix, Amar Gajjar, Christopher J. Eden, Richard J. Gilbertson
Publikováno v:
Cancer Research. 71:4759-4759
Ependymomas are rare brain tumors that are incurable unless completely excised. The low incidence of the disease and lack of pre-clinical models has limited research efforts to advance understanding of biology and treatment. Recently, we used intersp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb62855df3f7ee4c1e5461d2a772544a
https://doi.org/10.1158/1538-7445.am2011-4759
https://doi.org/10.1158/1538-7445.am2011-4759
Autor:
Alexander Arnold, Helen Poppleton, Anang A. Shelat, Elsie White, Robert A. Johnson, Tanya A. Kranenburg, Richard J. Gilbertson, R. Kip Guy, Jennifer M. Atkinson, Kumarasamypet M. Mohankumar, Clementine Feau, Karen Wright
Publikováno v:
Molecular Cancer Therapeutics. 8:A52-A52
Brain tumors are often chemoresistant and these diseases are heterogeneous complicating efforts to discover effective new therapies. We describe a powerful interspecies genomics approach that meticulously matches subgroup specific driver mutations wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::091859c377c0fab7c8f9aea68eecb4b4
https://doi.org/10.1158/1535-7163.targ-09-a52
https://doi.org/10.1158/1535-7163.targ-09-a52