Výsledky vyhledávání - "R. Kim Brazzell"

Safety and efficacy of twice daily administration of KPI-121 1% for ocular inflammation and pain following cataract surgery

Autor: R Kim Brazzell, Edward J. Holland, Kenneth N Sall, Susan Coultas, Terry Kim, Preeya K. Gupta

Publikováno v: Clinical Ophthalmology (Auckland, N.Z.)

Terry Kim,1 Kenneth Sall,2 Edward J Holland,3 R Kim Brazzell,4 Susan Coultas,4 Preeya K Gupta1 1Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA; 2Sall Research Medical Center, Inc, Artesia, CA, USA; 3Department of Ophthalmolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd9b5d07be6227f0bf82df757485d42
https://doi.org/10.2147/opth.s185800

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Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma

Autor: Reza M. Haque, R. Kim Brazzell, Paul L. Kaufman, Robert Ritch, Carol A. Rasmussen, Jason L Vittitow

Publikováno v: Translational vision sciencetechnology. 3(5)

To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d83f8befb21cf1ed2f7bcb83a24764
https://pubmed.ncbi.nlm.nih.gov/25237590

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High-Performance Liquid Chromatographic Assay of the Aldose Reductase Inhibitor Spiro-(2-fluoro-9h-fluorene-9,4′-imidazolidine)-2′,5′-dione (AL01567) in Plasma and Urine and Its Pharmacokinetics in Humans

Autor: Richard E. Dobbs, Bette A. McCue, Young Han Park, R. Kim Brazzell, Billie M. York

Publikováno v: Journal of Pharmaceutical Sciences. 77:591-595

Two selective high-performance liquid chromatographic (HPLC) methods have been developed for the quantitative determination of spiro-(2-fluoro-9H-fluorene-9,4′-imidazolidine)-2′,5′-dione (AL01567; 1 ) in plasma and urine, with an assay sensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fc71678542acf53cea00e5b362963d
https://doi.org/10.1002/jps.2600770709

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The prevention of biochemical changes in lens, retina, and nerve of galactosemic dogs by the aldose reductase inhibitor AL01576

Autor: Jaime E. Dickerson, Michael L. Chandler, R. Kim Brazzell, Marjorie F. Lou, Billie M. York

Publikováno v: Journal of ocular pharmacology. 5(3)

Normal eight month old beagle dogs were fed a diet of 30% galactose for a period of two weeks. One group of dogs was untreated while three other groups were orally dosed with 0.25, 1.0, and 5.0 mg/kg of the aldose reductase inhibitor (ARI), AL01576.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132966ec894cd5cbfa005a990ffa29c5
https://pubmed.ncbi.nlm.nih.gov/2516529

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Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients

Autor: Michael Weintraub, J. C. Liao, R. Kim Brazzell, Richard E. Dobbs, Mordechai Averbuch

Publikováno v: Journal of clinical pharmacology. 28(8)

The safety and biochemical effects of AL 1576 (HOE 483), a recently developed aldose reductase inhibitor, were evaluated. In a double-blind, placebo-controlled, clinical trial, AL 1576 (HOE 483) was administered to diabetic patients for the first tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4776e572e2ff09bea824f267f32743d
https://pubmed.ncbi.nlm.nih.gov/3145943

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