Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. Kelly Moore"'
Publikováno v:
Proceedings of the National Academy of Sciences. 102:5426-5431
There has been significant attention to the growing recognition that oocytes have a critical capacity to organize and govern surrounding somatic cells. Bone morphogenetic protein 15 (BMP-15) is an oocyte-secreted factor that has raised particular int
Publikováno v:
Trends in Endocrinology & Metabolism. 15:356-361
How do mammals control the number of eggs that are ovulated during the estrous and menstrual cycles? Our understanding of this fundamental process has grown in recent years as a result of intense efforts to identify and characterize the genes that co
Publikováno v:
International Congress Series. 1266:241-247
Although bone morphogenetic proteins (BMPs) have been well-known regulators in ectopic formation of bone and cartilage, as well as in early embryonic development, nothing was known about the role of the BMP system in regulating ovarian function until
Publikováno v:
Journal of Biological Chemistry. 278:3713-3719
Bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9 (GDF-9) are members of the transforming growth factor-β superfamily. Both molecules are closely related in their primary structures and share a nearly identical spatiotem
Publikováno v:
Biochemical and Biophysical Research Communications. 289:961-966
Recent studies have highlighted the importance of a novel oocyte-derived growth factor, bone morphogenetic protein-15 (BMP-15) in the regulation of proliferation and differentiation of granulosa cells in the ovary. Namely, BMP-15 stimulates granulosa
Publikováno v:
Journal of Biological Chemistry. 276:32889-32895
The process of ovarian folliculogenesis is composed of proliferation and differentiation of the constitutive cells in developing follicles. Growth factors emitted by oocytes integrate and promote this process. Growth differentiation factor-9 (GDF-9),
Publikováno v:
Endocrinology. 146(8)
The establishment of dominant ovarian follicles that are capable of ovulating fertilizable oocytes is a fundamental determinant of female fertility. This process is governed by pituitary gonadotropins as well as local ovarian factors. Within the foll
Autor:
R. Kelly Moore, Shunichi Shimasaki
Publikováno v:
Molecular and cellular endocrinology. 234(1-2)
The oocyte factor, bone morphogenetic protein-15 (BMP-15) has proven to be critical for normal fertility in female mammals. The biological functions of recombinant BMP-15 demonstrate its capacity to promote granulosa cell processes involved in early
Publikováno v:
The Journal of biological chemistry. 279(17)
Bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9 (GDF-9) are oocyte-secreted factors that are critical local regulators of ovarian physiology. Recent studies have identified a number of mutations in these genes that caus
Publikováno v:
Endocrine reviews. 25(1)
Using molecular, cellular, and genetic approaches, recent studies examining the role of the bone morphogenetic protein (BMP) family of growth factors in the reproductive system have led to significant breakthroughs in our understanding of mammalian r