Zobrazeno 1 - 10
of 177
pro vyhledávání: '"R. Keeble"'
Autor:
Meagan S. Kingren, Alexander R. Keeble, Alyson M. Galvan-Lara, Jodi M. Ogle, Zoltán Ungvári, Daret K. St Clair, Timothy A. Butterfield, Allison M. Owen, Christopher S. Fry, Samir P. Patel, Hiroshi Saito
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Sepsis, mainly caused by bacterial infections, is the leading cause of in-patient hospitalizations. After discharge, most sepsis survivors suffer from long-term medical complications, particularly chronic skeletal muscle weakness.
Externí odkaz:
https://doaj.org/article/2a5851bddea14470973d44fc590c574b
Autor:
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising
Externí odkaz:
https://doaj.org/article/bd2c80f1e7bf42fd9e877971c7a909b7
Autor:
Samer Fawaz, Federico Marin, Sarosh A Khan, Rupert F G Simpson, Rafail A Kotronias, Jason Chai, Oxford Acute Myocardial Infarction (OxAMI) Study Investigators, Firas Al-Janabi, Rohan Jagathesan, Klio Konstantinou, Shah R Mohdnazri, Gerald J Clesham, Kare H Tang, Christopher M Cook, Keith M Channon, Adrian P Banning, John R Davies, Grigoris V Karamasis, Giovanni L De Maria, Thomas R Keeble
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 51, Iss , Pp 101374- (2024)
Background: The assessment of coronary microvascular dysfunction (CMD) using invasive methods is a field of growing interest, however the preferred method remains debated. Bolus and continuous thermodilution are commonly used methods, but weak agreem
Externí odkaz:
https://doaj.org/article/659aa0243cca4419aeb5a1ea4af6732d
Autor:
Erik Blennow Nordström, Susanna Vestberg, Lars Evald, Marco Mion, Magnus Segerström, Susann Ullén, John Bro-Jeppesen, Hans Friberg, Katarina Heimburg, Anders M. Grejs, Thomas R. Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander, Johan Undén, Niklas Nielsen, Tobias Cronberg, Gisela Lilja
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-13 (2023)
Abstract Background Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that
Externí odkaz:
https://doaj.org/article/55bd12ed1dd348d1b01fe8db12f7cbe1
Autor:
Sarosh Khan, MBBS, Rohan Jagathesan, MD, Olivia M.T. Frost, BSc, Iveta Crawford, BSc, Sheila Smith, BSc, Swamy Gedela, MBBS, Samer Fawaz, BMBS, Rupert Simpson, MBChB, Arvind Singh, MBBS, Grigoris V. Karamasis, MD, Thomas R. Keeble, MD, John R. Davies, PhD, Alamgir Kabir, PhD, Rajesh Aggarwal, MD, Christopher M. Cook, PhD
Publikováno v:
Structural Heart, Vol 8, Iss 1, Pp 100232- (2024)
Externí odkaz:
https://doaj.org/article/c6f508aacf084d7cab72e40612def80e
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a
Autor:
Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen, Thomas R. Keeble
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-8 (2022)
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normoth
Externí odkaz:
https://doaj.org/article/1b49f62482924e41af89166639f8b9c0
Autor:
Samer Fawaz, Daniel Munhoz, Thabo Mahendiran, Emanuele Gallinoro, Takuya Mizukami, Sarosh A. Khan, Rupert F. G. Simpson, Johan Svanerud, Christopher M. Cook, John R. Davies, Grigoris V. Karamasis, Bernard De Bruyne, Thomas R. Keeble
Publikováno v:
Diagnostics, Vol 14, Iss 3, p 285 (2024)
Continuous Thermodilution is a novel method of quantifying coronary flow (Q) in mL/min. To account for variability of Q within the cardiac cycle, the trace is smoothened with a 2 s moving average filter. This can sometimes be ineffective due to signi
Externí odkaz:
https://doaj.org/article/e9ab77c26d3d44aa963e23d4179f2cc0
Autor:
Klio Konstantinou, John R. Davies, Osama Alsanjari, Paul A. Kelly, Kare H. Tang, George Kassimis, Dimitrios Alexopoulos, Gerald J. Clesham, Thomas R. Keeble, Grigoris V. Karamasis
Publikováno v:
Hellenic Journal of Cardiology, Vol 66, Iss , Pp 11-18 (2022)
Objective: The impact of adjunctive manual thrombus aspiration (TA) in patients with stent thrombosis (ST) treated with percutaneous intervention has not been evaluated in the current era of potent P2Y12 agents and new-generation drug-eluting stents.
Externí odkaz:
https://doaj.org/article/926cec8e848741bb8dd3718527bcd6cd
Autor:
Sarosh Khan, Samer Fawaz, Rupert Simpson, Craig Robertson, Paul Kelly, Shah Mohdnazri, Kare Tang, Christopher M. Cook, Sean Gallagher, Peter O’Kane, James Spratt, Emmanouil S. Brilakis, Grigoris V. Karamasis, Rasha Al-Lamee, Thomas R. Keeble, John R. Davies
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundPercutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) has been performed for the improvement of symptoms and quality of life in patients with stable angina. The ORBITA study demonstrated the role of the placebo
Externí odkaz:
https://doaj.org/article/4c054113640447388093f80b19c8d715