Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Autor: N. T. Ventham, N. A. Kennedy, A. T. Adams, R. Kalla, S. Heath, K. R. O'Leary, H. Drummond, IBD BIOM consortium, IBD CHARACTER consortium, D. C. Wilson, I. G. Gut, E. R. Nimmo, J. Satsangi

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are

Externí odkaz: https://doaj.org/article/03f4cfccee3b45d1b75ae6adcb9da079

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Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)

Autor: A B Kristoffersen, Aina Elisabeth Fossum Moen, Jørgen Jahnsen, Trond Espen Detlie, Daniel Bergemalm, Jonas Halfvarson, Jack Satsangi, Christine Olbjørn, T Tannaes, C. Casén, C M Lindquist, Johan D. Söderholm, F Gomollón, Simen Vatn, Morten H. Vatn, Jonas Christoffer Lindstrøm, R Kalla, Petr Ricanek, Adam Carstens

Publikováno v: Scandinavian journal of gastroenterology. 55(10)

Method We examined faecal samples, using the GA-map™ Dysbiosis Test, to associate gut microbiota composition with Crohn’s disease (CD) and ulcerative colitis (UC) and to identify markers for future biomarker identification. We conducted a prospec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab0d6148c2dc57dad891e56e402695f
https://pubmed.ncbi.nlm.nih.gov/32780604

Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Autor: A Chauhan, T Lalor, S Watson, D Adams, T E Farrah, A Anand, R Kimmitt, N L Mills, D J Webb, N Dhaun, R Kalla, A Adams, S Vatn, F Bonfliglio, E Nimmo, N Kennedy, N Ventham, M Vatn, P Ricanek, J Halfvarson, J Soderhollm, M Pierik, L Torkvist, F Gomollon, I Gut, J Jahnsen, J Satsangi, R Body, M Almashali, G McDowell, P Taylor, A Lacey, A Rees, null Ludgate, C Dayan, J Lazarus, S Nelson, O Okosieme, D Corcoran, R Young, P Ciadella, P McCartney, A Bajrangee, B Hennigan, D Collison, D Carrick, A Shaukat, R Good, S Watkins, M McEntegart, J Watt, P Welsh, N Sattar, A McConnachie, K Oldroyd, C Berry, T Parks, K Auckland, A J Mentzer, J Kado, M M Mirabel, J K Kauwe, K J Robson, B Mittal, A C Steer, A V S Hill, M Akbar, M Forrester, A T Virlan, A Gilmour, C Wallace, C Paterson, D Reid, S Siebert, D Porter, J Liversidge, I McInnes, C Goodyear, V Athwal, J Pritchett, A Zaitoun, W Irving, I N Guha, N A Hanley, K P Hanley, T Briggs, J Reynolds, G Rice, V Bondet, E Bruce, Y Crow, D Duffy, B Parker, I Bruce, K Martin, M Aoibheann Mullan, J Llewellyn, L Zeef, S Farrow, C Streuli, N Henderson, S Friedman, N Hanley

Publikováno v: Chauhan, A, Lalor, T, Watson, S, Adams, D, Farrah, T E, Anand, A, Kimmitt, R, Mills, N L, Webb, D J, Dhaun, N, Kalla, R, Adams, A, Vatn, S, Bonfliglio, F, Nimmo, E, Kennedy, N, Ventham, N, Vatn, M, Ricanek, P, Halfvarson, J, Soderhollm, J, Pierik, M, Torkvist, L, Gomollon, F, Gut, I, Jahnsen, J, Satsangi, J, Body, R, Almashali, M, McDowell, G, Taylor, P, Lacey, A, Rees, A, Dayan, C, Lazarus, J, Nelson, S, Okosieme, O, Corcoran, D, Young, R, Ciadella, P, McCartney, P, Bajrangee, A, Hennigan, B, Collison, D, Carrick, D, Shaukat, A, Good, R, Watkins, S, McEntegart, M, Watt, J, Welsh, P, Sattar, N, McConnachie, A, Oldroyd, K, Berry, C, Parks, T, Auckland, K, Mentzer, A J, Kado, J, Mirabel, M M, Kauwe, J K, Robson, K J, Mittal, B, Steer, A C, Hill, A V S, Akbar, M, Forrester, M, Virlan, A T, Gilmour, A, Wallace, C, Paterson, C, Reid, D, Siebert, S, Porter, D, Liversidge, J, McInnes, I, Goodyear, C, Athwal, V, Pritchett, J, Zaitoun, A, Irving, W, Guha, I N, Hanley, N A, Hanley, K P, Briggs, T, Reynolds, J, Rice, G, Bondet, V, Bruce, E, Crow, Y, Duffy, D, Parker, B, Bruce, I, Martin, K, Pritchett, J, Aoibheann Mullan, M, Llewellyn, J, Athwal, V, Zeef, L, Farrow, S, Streuli, C, Henderson, N, Friedman, S, Hanley, N A & Hanley, K P 2018, ' Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland ', pp. 920-924 . https://doi.org/10.1093/qjmed/hcy193

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4663511d656e8340c436f5bbd7530542
https://doi.org/10.1093/qjmed/hcy193