Zobrazeno 1 - 10
of 45
pro vyhledávání: '"R. K. Verbeeck"'
Autor:
Nicole Maton, M. Zurini, Reiner Dieden, A. Aubry, D. Latinne, Georges Lhoëst, C Baldari, R. K. Verbeeck
Publikováno v:
Scopus-Elsevier
Cyclosporin A (CsA) and IMM-125, a hydroxyethyl derivative of D-serine CsA, are cyclic undecapeptides of molecular weight 1201.8 and 1261.8, respectively. The main metabolites still possessing the undecapeptide structure were found to be compounds re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132f068cef7676f80ee235a8bf667725
https://doi.org/10.1155/2000/491283
https://doi.org/10.1155/2000/491283
Publikováno v:
Xenobiotica. 27:869-883
1. Rapamycin is metabolically transformed in rat liver microsomes to 3,4- and 5,6-dihydrodiol metabolites under the influence of the cytochrome P-450 mixed function oxygenase system. These metabolites were produced from dexamethasone-induced as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edea2bb6a98977139b686a514381b08
https://doi.org/10.1080/004982597240055
https://doi.org/10.1080/004982597240055
Autor:
R. K. Verbeeck, Anaïs Scohy, Raymond Reding, Vanessa Guy-Viterbo, Ft. Musuamba, Pierre Wallemacq
Publikováno v:
European journal of clinical pharmacology. 69(8)
PURPOSES: Tacrolimus (TAC) is the most widely used immunosuppressant for the prevention of acute rejection after solid organ transplantation. Its pharmacokinetics (PK) show considerable variability, making TAC a good candidate for therapeutic drug mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff16c40d0aef88b06af557f37eb7ea1b
https://pubmed.ncbi.nlm.nih.gov/23588560
https://pubmed.ncbi.nlm.nih.gov/23588560
Autor:
Ft. Musuamba, Michel Mourad, Jean-Louis Bosmans, J. J. Sennesael, R. K. Verbeeck, Vincent Haufroid, Pierre Wallemacq
Publikováno v:
Scopus-Elsevier
Acta clinica Belgica : supplementum
Acta clinica Belgica : supplementum
Objective: Mycophenolic acid (MPA) and Tacrolimus (TAC) are immunosuppressive drugs routinely used after solid organ transplantation. MPA and TAC have a rather narrow therapeutic window and their pharmacokinetics show considerable variability. In mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f81c5104a5d87c7ea4b31c2a9309462
https://hdl.handle.net/20.500.14017/7947a031-1db7-4921-9159-80d01e09ba57
https://hdl.handle.net/20.500.14017/7947a031-1db7-4921-9159-80d01e09ba57
Publikováno v:
Xenobiotica. 21:1535-1546
1. The disposition of diflunisal (DF) was investigated in bile-exteriorized and intact homozygous Gunn rats given 10 and 50 mg/kg doses i.v. and in Wistar rats given 10 mg/kg doses i.v. 2. In Gunn rats, DF sulphate, DF acyl glucuronide, and a hithert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c2f2f2b2d4a3a5e5299fbfc7e76890
https://doi.org/10.3109/00498259109044403
https://doi.org/10.3109/00498259109044403
Publikováno v:
Journal of pharmaceutical sciences. 94(7)
Literature data on the properties of chloroquine phosphate, chloroquine sulfate, and chloroquine hydrochloride related to the Biopharmaceutics Classification System (BCS) are reviewed. The available information indicates that these chloroquine salts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98bdfce627d2500cabcc3d2b7797aab1
https://pubmed.ncbi.nlm.nih.gov/15920763
https://pubmed.ncbi.nlm.nih.gov/15920763
Publikováno v:
Journal of mass spectrometry : JMS. 36(8)
Different tacrolimus epoxides and dihydrodiol epoxides arising from the chemical oxidation of the parent drug are described. Open-chain tautomeric forms involving the lactone function were identified for the tacrolimus epoxides. Moreover, the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bd62b1ccb029a3a3aaeaef256b29c3e
https://pubmed.ncbi.nlm.nih.gov/11523088
https://pubmed.ncbi.nlm.nih.gov/11523088
Autor:
N M, Delzenne, R K, Verbeeck
Publikováno v:
Journal de pharmacie de Belgique. 56(2)
The nutritional state, and/or the ingestion of specific nutrients, is/are able to modify drug disposition, by interfering with drug absorption, distribution, storage, and metabolism. Recent data report that nutrients interfere with drug metabolism ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4767e64b57c227080fb7e1dbd4b68402
https://pubmed.ncbi.nlm.nih.gov/11396348
https://pubmed.ncbi.nlm.nih.gov/11396348
Autor:
V P, Vanhulle, G A, Martiat, R K, Verbeeck, Y, Horsmans, P B, Calderon, S L, Eeckhoudt, H S, Taper, N, Delzenne
Publikováno v:
Life sciences. 68(21)
Several cryopreservation methods for precision-cut rat liver slices (PCLS) have been proposed, allowing a short-term (a few hours) maintainance of viability and functionality upon thawing. The aim of the present study was to test the metabolic capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f4b479f5e9477cb78b14d3aa5f53148
https://pubmed.ncbi.nlm.nih.gov/11350010
https://pubmed.ncbi.nlm.nih.gov/11350010
Autor:
H, Rafatro, R K, Verbeeck, T Y, Gougnard, P J, De Jonghe, P, Rasoanaivo, A, Laurent, G, Lhoëst
Publikováno v:
Journal of mass spectrometry : JMS. 35(9)
Malagashanine has been isolated from indigenous madagascan Strychnos myrtoides alkaloids used traditionally to treat malaria. This alkaloid was found to enhance the action of chloroquine against chloroquine-resistant strains of Plasmodium falciparum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe31081e8210f9e3aed6f93061909c24
https://pubmed.ncbi.nlm.nih.gov/11006605
https://pubmed.ncbi.nlm.nih.gov/11006605