Výsledky vyhledávání - "R. K. Prinjha"

Akademický článek

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Autor: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes, P. Grandi

Publikováno v: Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-18 (2019)

Abstract Background Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifi

Externí odkaz: https://doaj.org/article/71909f5c8c3347fda4bcaf156c6692f4

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Nogo A expression in the adult enteric nervous system

Autor: Shona L. Osborne, S. E. Moore, S. L. Corcoran, R. K. Prinjha

Publikováno v: Neurogastroenterology and Motility. 16:465-474

Neuronal plasticity plays an important role in physiological and pathological processes within the gastrointestinal (GI) tract. Nogo A is a major contributor to the negative effect central nervous system (CNS) myelin has on neurite outgrowth after in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb871ebcc9de944b656550b56d09c150
https://doi.org/10.1111/j.1365-2982.2004.00527.x

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Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

Publikováno v: Leukemia

Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia (AML). Here we validate this hypothesis, demonstrating the efficacy of the BET inhibitor I-BE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb89339bf14fc4203dfae5c589cc9cdf
https://pubmed.ncbi.nlm.nih.gov/24220271

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Cloning and sequencing of cDNAs encoding the actin cross-liking protein transgelin defines a new family of actin-associated proteins

Autor: J. Justin Hsuan, Claire Shapland, R. K. Prinjha, Nick Totty, Durward Lawson, I. J. Mason

Publikováno v: Cell Motility and the Cytoskeleton. 28:243-255

We have used degenerate oligonucleotides, derived from the amino acid sequence of transgelin peptides [Shapland et al., 1993: J. Cell Biol. 121:1065-1073], to isolate and sequence overlapping cDNA clones encoding this actin gelling protein. Primers w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3443beee9f553c259a1c08858a613470
https://doi.org/10.1002/cm.970280307

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Akademický článek

The Pseudo-Natural Product Tafbromin Selectively Targets the TAF1 Bromodomain 2.

Autor: Patil S; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Cremosnik G; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Dötsch L; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany.; Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, Dortmund, 44227, Germany., Flegel J; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Schulte B; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Maier KC; Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany., Žumer K; Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany., Cramer P; Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany., Janning P; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Sievers S; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Ziegler S; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany., Waldmann H; Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund, 44227, Germany.; Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, Dortmund, 44227, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Aug 05; Vol. 63 (32), pp. e202404645. Date of Electronic Publication: 2024 Jul 04.

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Akademický článek

Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review.

Autor: Gerges A; Bioscience Department, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, England, United Kingdom., Canning U; Bioscience Department, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, England, United Kingdom.

Publikováno v: ChemMedChem [ChemMedChem] 2024 May 02; Vol. 19 (9), pp. e202300535. Date of Electronic Publication: 2024 Mar 26.

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Akademický článek

BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma.

Autor: Liu, Dongdong¹ (AUTHOR), Li, Zhen¹ (AUTHOR), Tan, Dongxia¹ (AUTHOR), An, Yang¹ (AUTHOR), Chu, Liping¹ (AUTHOR), Chen, Tiancheng¹ (AUTHOR), Li, Weijia¹ (AUTHOR), Zhou, Ailin¹ (AUTHOR), Xiang, Ruijie¹ (AUTHOR), Zhang, Liye¹ (AUTHOR), Qu, Yuxiu¹ (AUTHOR), Qi, Wei^1,2 (AUTHOR) qiwei@shanghaitech.edu.cn

Publikováno v: Advanced Science. 3/27/2024, Vol. 11 Issue 12, p1-17. 17p.

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Akademický článek

Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS).

Autor: Pal S; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Nare Z; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Rao VA; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Smith BO; University of Glasgow, School of Molecular Biosciences, College of Medical Veterinary and Life Sciences, G12 8QQ, Glasgow, UK., Morrison I; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Fitzgerald EA; Malvern Panalytical, Zugerstrasse 76, CH-8820, Wädenswil, Switzerland., Scott A; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Bingham MJ; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK., Pesnot T; Concept Life Sciences, Frith Knoll Road, Chapel-en-le-Frith, SK23 0PG, High Peak, UK.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Mar 15; Vol. 19 (6), pp. e202300590. Date of Electronic Publication: 2024 Mar 01.

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Akademický článek

EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN.

Autor: Yao, Bing¹ (AUTHOR) byao@njmu.edu.cn, Xing, Mengying¹ (AUTHOR), Meng, Shixin¹ (AUTHOR), Li, Shang¹ (AUTHOR), Zhou, Jingwan¹ (AUTHOR), Zhang, Ming¹ (AUTHOR), Yang, Chen² (AUTHOR), Qu, Shuang³ (AUTHOR), Jin, Yucui¹ (AUTHOR), Yuan, Hongyan⁴ (AUTHOR), Zen, Ke² (AUTHOR) kzen@nju.edu.cn, Ma, Changyan^1,5 (AUTHOR) cyma@njmu.edu.cn

Publikováno v: Advanced Science. 1/15/2024, Vol. 11 Issue 2, p1-15. 15p.

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