Zobrazeno 1 - 10
of 31
pro vyhledávání: '"R. K. Minkes"'
Autor:
Dennis B. McNamara, Timothy J. McMahon, R. K. Minkes, P. J. Kadowitz, Bobby D. Nossaman, J. S. Hood, J. A. Bellan, T. R. Higuera
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 263:H234-H243
Pulmonary and systemic vascular responses to platelet-activating factor (PAF) were investigated in the anesthetized cat. Intravenous injections of PAF decreased arterial pressure, increased pulmonary arterial pressure, and caused small but significan
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 262:H852-H861
Cardiovascular and pulmonary responses to sarafotoxin (S) 6a and S6c were investigated in the anesthetized cat. Intravenous injections of the peptides in doses of 0.1-1.0 nmol/kg caused decreases or biphasic changes in arterial pressure (AP) and incr
Autor:
Dennis B. McNamara, P. J. Kadowitz, J. S. Hood, Timothy J. McMahon, David H. Coy, William A. Murphy, R. K. Minkes
Publikováno v:
Journal of Applied Physiology. 72:1212-1217
Responses to pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide derived from ovine hypothalamus with 68% sequence homology with vasoactive intestinal polypeptide (VIP), were investigated in the pulmonary and hindquarters vasc
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H957-H966
Cardiovascular and pulmonary responses to cromakalim, a member of a novel class of antihypertensive agents that open ATP-sensitive K+ (K+ATP) channels, were investigated in the anesthetized cat. Intravenous injections of cromakalim in doses of 30-300
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1025-H1029
The effects of N omega-nitro-L-arginine (nitroarginine), an inhibitor of endothelium-dependent relaxing factor (EDRF) production, on vascular tone and responses to vasodilator and vasoconstrictor agents were investigated in the hindquarters vascular
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:S374-377
The role of cyclooxygenase product formation and thromboxane A2 receptor activation in the response to endothelin-1 (ET-1) was investigated and compared in the airways and in the pulmonary vascular bed of the intact-chest cat. Intravenous injections
Autor:
Philip J. Kadowitz, R. K. Minkes
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:S293-296
Hemodynamic responses to sarafotoxin (SFTX6) peptides and endothelin-1 (ET-1) were compared in the anesthetized cat. SFTX6a and ET-1 at a dose of 0.3 nmol/kg i.v. produced a biphasic change in arterial pressure characterized by an initial decrease fo
Autor:
P. J. Kadowitz, R. K. Minkes
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 258:H1550-H1558
Cardiovascular responses to endothelin 2 (ET-2) and sarafotoxin 6b (S6b) were investigated in the cat. ET-2 (0.1-1 nmol/kg iv) decreased or elicited biphasic changes in arterial pressure (AP), whereas S6b (0.1-1 nmol/kg iv) only decreased AP. Central
Publikováno v:
The American journal of physiology. 269(5 Pt 2)
The mechanism underlying reactive hyperemia was investigated in the feline hindquarters vascular bed under natural- and constant-flow conditions. A 30-s occlusion of the distal aorta produced a marked hyperemic increase in distal aortic blood flow th
Autor:
R. K. Minkes, Philip J. Kadowitz, Mahesh C. Khosla, Suzette Y. Osei, Joseph P. Weaver, Rexford S. Ahima
Publikováno v:
European journal of pharmacology. 234(1)
Regional vascular responses to angiotensin (Ang)-(1-7), a heptapeptide derivative of Ang II were investigated in the feline hindquarters and mesenteric vascular beds under conditions of controlled flow. In the mesenteric vascular bed, injections of A