Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R. K. McPherson"'
Autor:
George A. Karam, Walter C. Soeller, Paul Bauer, Carty, L. D. Mcclure, Judith L. Treadway, Alan M. Mathiowetz, N.B. Nestor, Leslie R. Pustilnik, Carolyn B. Levy, David L. Hageman, Anthony Carlo, Ing-Kae Wang, Dennis E. Danley, Jayvardhan Pandit, Mahmoud N. Mansour, R K McPherson, Stephen W. Wright, Gayle K. Schulte
Publikováno v:
Journal of Medicinal Chemistry. 45:3865-3877
The synthesis and in vitro structure-activity relationships (SAR) of a novel series of anilinoquinazolines as allosteric inhibitors of fructose-1,6-bisphosphatase (F16Bpase) are reported. The compounds have a different SAR as inhibitors of F16Bpase t
Autor:
T G Gant, Y Kwon, Judith L. Treadway, P A Carpino, Maria A. Vanvolkenburg, S H Burk, Janice C. Parker, P Vestergaard, Carolyn B. Levy, William H. Martin, R K McPherson, C Giragossian
Publikováno v:
Diabetes. 47:1630-1636
The activity of glucose-6-phosphatase (G-6-Pase) in isolated rat microsomes was inhibited by a new selective inhibitor of the multi-subunit G-6-Pase system, 1-[2-(4-chloro-phenyl)-cyclopropylmethoxy]-3,4-dihydroxy-5-(3-imid azo[4,5-b]pyridin-1-yl-3-p
Autor:
Dennis J. Hoover, William H. Martin, R W Stevenson, Dennis E. Danley, Judith L. Treadway, Ingrid A. Stock, E J Barrett, Sandra J Armento, R K McPherson
Publikováno v:
Proceedings of the National Academy of Sciences. 95:1776-1781
An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro and in vivo . This substance, [R-(R*,S*)]-5-chloro- N -[3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide (CP-
Autor:
R W Stevenson, J Spitzer, A G Swick, P. E. Genereux, K. M. Andrews, J J Herbst, R K McPherson, L M Persson, David K. Kreutter, E. M. Gibbs
Publikováno v:
Diabetes. 45:60-66
The effects of englitazone in male Wistar rats fed a high-fat diet (59% of calories as fat) were compared with control rats fed a high-carbohydrate diet (69% of calories as carbohydrate) (5–15 animals per group). Insulin-stimulated (17 nmol/l) 2-de
Autor:
Nancy A. Nardone, J E Pessin, J F Russo, Diane M. Hargrove, R. K. Mcpherson, E M Gibbs, H A Stukenbrok, Anthony J. Milici, Judith L. Treadway, R W Stevenson
Publikováno v:
Journal of Biological Chemistry. 269:29956-29961
Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance compared with nontransgenic controls (Liu, M.-L., Gibbs, E. M., McCoid, S. C., Milici, A. J., S
Autor:
R. W. Stevenson, N. J. Hutson, M. N. Krupp, R. A. Volkmann, G. F. Holland, J. F. Eggler, D. A. Clark, R. K. McPherson, K. L. Hall, B. H. Danbury, al. et
Publikováno v:
Diabetes. 39:1218-1227
Autor:
Y Sugie, T Inagaki, Janice E. Chin, K A Dekker, Carolyn B. Levy, D A Perry, Jeffrey S. Dubins, R K McPherson, Janice C. Parker, P V Perry, B Hulin, Judith L. Treadway, K Tachikawa, K M Andrews
Publikováno v:
Diabetes. 49(12)
Peptidic glucagon antagonists have been shown to lower blood glucose levels in diabetic models (1-3), but attempts to identify small molecular weight glucagon receptor-binding antagonists have met with little success. Skyrin, a fungal bisanthroquinon
Autor:
Sandra J Armento, E. M. Gibbs, William H. Martin, Dennis J. Hoover, Paul E. Genereux, Judith L. Treadway, Ingrid A. Stock, R K McPherson, J L Burgess-Henry, S Lefkowitz-Snow
Publikováno v:
Journal of medicinal chemistry. 41(16)
Autor:
J L, Treadway, D M, Hargrove, N A, Nardone, R K, McPherson, J F, Russo, A J, Milici, H A, Stukenbrok, E M, Gibbs, R W, Stevenson, J E, Pessin
Publikováno v:
The Journal of biological chemistry. 269(47)
Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance compared with nontransgenic controls (Liu, M.-L., Gibbs, E. M., McCoid, S. C., Milici, A. J., S
Autor:
A J Milici, E M Gibbs, Min-Ling Liu, R. K. Mcpherson, Jeffrey E. Pessin, Judith L. Treadway, Scott C. McCoid, H A Stukenbrok
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(23)
To examine the physiological role of the GLUT4/muscle-fat specific facilitative glucose transporter in regulating glucose homeostasis, we have generated transgenic mice expressing high levels of this protein in an appropriate tissue-specific manner.