Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R. K. Kuester"'
Autor:
Rachna T. Shroff, Mohammad Khreiss, Jayati Chakrabarti, Joanne Lundy, Nina Steele, Scott S. Richards, Jiang Wang, Daniel Croagh, Aaron Scott, Chantal Woodson, R. K. Kuester, Timothy L. Frankel, Loryn Holokai, Juanita L. Merchant, Brendan J. Jenkins, Yana Zavros, Syed A. Ahmad, Pritha Adhikary
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3816, p 3816 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3816, p 3816 (2020)
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with an approximate 10% five-year survival rate despite therapy. A plausible reason for this observation may be that other, redundant, immune-suppressive m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898a3b23fea7d9c51a1a45a8f7d353bf
Publikováno v:
Toxicology. 290:271-277
2, 2-Bis (bromomethyl)-1, 3-propanediol (BMP) is an extensively used brominated flame retardant found in urethane foams and polyester resins. In a two year dietary study conducted by the National Toxicology Program, BMP caused neoplastic lesions at m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8495ce3b63d8fb331ca3c34f9dc7f
https://doi.org/10.1016/j.tox.2011.10.006
https://doi.org/10.1016/j.tox.2011.10.006
Autor:
Yaofeng Cheng, I. Glenn Sipes, Lucy J. Martinez-Guerrero, R. K. Kuester, Stephen H. Wright, Michelle J. Hooth
Publikováno v:
Drug Metabolism and Disposition. 39:1755-1761
Ionic liquids (ILs) are a class of salts that are expected to be used as a new source of solvents and for many other applications. Our previous studies revealed that selected ILs, structurally related organic cations, are eliminated exclusively in ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5b35b6d881bfa8d7f7856fcb6dfd20
https://doi.org/10.1124/dmd.110.035865
https://doi.org/10.1124/dmd.110.035865
Publikováno v:
Drug Metabolism and Disposition. 36:284-293
These studies characterize the effect of dose and route of administration on the disposition and elimination of the ionic liquid, 1-butyl-3-methylimidazolium chloride (Bmim-Cl). After i.v. (5 mg/kg) or oral (50 mg/kg) administration to male F-344 rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16460f4caf9c7f552a000ad7558f0d51
https://doi.org/10.1124/dmd.107.018515
https://doi.org/10.1124/dmd.107.018515
Autor:
I. G. Sipes, R. K. Kuester
Publikováno v:
Drug Metabolism and Disposition. 35:1910-1915
This study investigated the kinetics of glucuronidation of bisphenol A (BPA; 4,4'-dihydroxy-2,2-diphenylpropane) in cryopreserved human hepatocytes (HCs). Incubation conditions were developed using Sprague-Dawley rat HCs. For determination of the kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5b905c6fed3cf5ac43f94528e74d07
https://doi.org/10.1124/dmd.107.014787
https://doi.org/10.1124/dmd.107.014787
Publikováno v:
Food and Chemical Toxicology. 40:1757-1765
The primary objective of these studies was to determine the absorption, distribution, metabolism and excretion of isoeugenol following oral and intravenous administration to male Fischer-344 rats. Following a single oral dose of [14C]isoeugenol (156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893fca2525fdec8b165225f5a38858f2
https://doi.org/10.1016/s0278-6915(02)00183-7
https://doi.org/10.1016/s0278-6915(02)00183-7
Publikováno v:
Drug Metabolism and Disposition. 30:1180-1185
Studies have shown that in the rat, bisphenol A (BPA) is metabolized and eliminated primarily as a monoglucuronide, a metabolite without estrogenic activity. The purpose of this study was to determine the extent of monoglucuronide formation in monola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bef61eb610a05d3377594218b5b4e7b
https://doi.org/10.1124/dmd.30.11.1180
https://doi.org/10.1124/dmd.30.11.1180
Autor:
Peter L. Goering, I. Glenn Sipes, Michael P. Waalkes, Ben L. Fisher, R. K. Kuester, Robert S. McCuskey
Publikováno v:
Toxicological Sciences. 65:151-159
A number of reports document that Fischer 344 (F344) rats are more susceptible to chemically induced liver injury than Sprague-Dawley (SD) rats. Cadmium (CdCl2), a hepatotoxicant that does not require bioactivation, was used to better define the biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eca11660d2454c5f5b3ee60728b768d
https://doi.org/10.1093/toxsci/65.1.151
https://doi.org/10.1093/toxsci/65.1.151
Autor:
Peter L. Goering, Angela R. Neale, Edward A. Gordon, Terrye G. Zaremba, Victoria M. Hitchins, Mrunal S. Chapekar, R. K. Kuester
Publikováno v:
In Vitro & Molecular Toxicology. 13:125-136
Cultured murine macrophages (RAW 264.7) were used to evaluate the temporal relationships between cytotoxicity, phagocytosis, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) production, and alterations in expression of stress proteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e368689f7e3d0cc39aa9d6fff3588094
https://doi.org/10.1089/109793300440712
https://doi.org/10.1089/109793300440712
Publikováno v:
Toxicology and Applied Pharmacology. 163:141-148
1,2-Dichlorobenzene (1,2-DCB) is a potent hepatotoxicant in male Fischer 344 (F-344) rats but not in Sprague-Dawley (SD) rats. While Kupffer cell-dependent oxidative stress plays a role in the progression of 1,2-DCB-mediated liver injury, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212953414b03c714a9e4ec4fcd34ebce
https://doi.org/10.1006/taap.1999.8860
https://doi.org/10.1006/taap.1999.8860