Zobrazeno 1 - 10
of 427
pro vyhledávání: '"R. K. Humphries"'
Autor:
Y. Even, J. L. Bennett, S. Sekulovic, L. So, L. Yi, K. McNagny, R. K. Humphries, F. M. V. Rossi
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Gene therapy as well as methods capable of returning cells to a pluripotent state (iPS) have enabled the correction of genetic deficiencies in syngenic adult progenitors, reducing the need for immunosuppression in cell therapy approaches. However, in
Externí odkaz:
https://doaj.org/article/021f7a5b17c041088a438ca496b279ac
Autor:
Xiaoyan Jiang, Tobias Maetzig, C Fruhstorfer, Ryan Yen, R K Humphries, X Liu, Donna L. Forrest, Min Chen, Katharina Rothe
Publikováno v:
Leukemia
Tyrosine kinase inhibitor (TKI) therapies induce clinical remission with remarkable effects on chronic myeloid leukemia (CML). However, very few TKIs completely eradicate the leukemic clone and persistence of leukemic stem cells (LSCs) remains challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f728f1c70f458ffa6bf7bdc6024bc9
http://europepmc.org/articles/PMC5668499
http://europepmc.org/articles/PMC5668499
Autor:
Michael Heuser, T. R. Docking, N von Krosigk, L Sanchez Milde, Courteney Lai, Aly Karsan, Patty Rosten, Tobias Maetzig, Gudmundur L. Norddahl, T Lohr, R K Humphries
Publikováno v:
Blood Cancer Journal
Meningioma 1 (MN1) is an independent prognostic marker for normal karyotype acute myeloid leukemia (AML), with high expression linked to all-trans retinoic acid resistance and poor survival. MN1 is also a potent and sufficient oncogene in murine leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed02ebf5cea7ef8b985b5eae41be79e2
https://pubmed.ncbi.nlm.nih.gov/28960191
https://pubmed.ncbi.nlm.nih.gov/28960191
Autor:
Eric Yung, Amit Sharma, Anuhar Chaturvedi, Arnold Ganser, Bob Argiropoulos, Kerstin Görlich, Nidhi Jyotsana, Courteney Lai, Florian Kuchenbauer, Haiyang Yun, R K Humphries, Adrian Schwarzer, Michael Heuser
Publikováno v:
Leukemia. 29:157-168
Myeloid differentiation is blocked in acute myeloid leukemia (AML), but the molecular mechanisms are not well characterized. Meningioma 1 (MN1) is overexpressed in AML patients and confers resistance to all-trans retinoic acid-induced differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfa999585376997144457d92bd0d7f5
https://doi.org/10.1038/leu.2014.162
https://doi.org/10.1038/leu.2014.162
Autor:
Florian Kuchenbauer, Henning Urlaub, Hanibal Bohnenberger, R K Humphries, Carsten Müller-Tidow, Tobias Berg, Arefeh Rouhi, Federico Comoglio, Jasmin Corso, Lars Palmqvist, Thomas Oellerich, Anjali Cremer, Anthony R. Green, Kimberly Stegmaier, Philipp Ströbel, Halvard Bonig, Hubert Serve, Astrid Wachter, Frank Schnütgen, Joachim Beck, Ekkehard Schütz, Timm Schroeder, Sebastian Mohr, Tim Beissbarth, Stefanie Göllner, Michael A. Rieger, Nadine Haetscher, Carmen Doebele, Gabriela Alexe
Publikováno v:
Cancer Cell
Cancer Cell, 31 (4)
Cancer Cell, 31 (4)
Summary The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efacd144f9b8d6f3595037a9fef22cc8
https://pubmed.ncbi.nlm.nih.gov/28399410
https://pubmed.ncbi.nlm.nih.gov/28399410
Autor:
Cedric A. Brimacombe, Carl L. Hansen, Ivan Sloma, Philip A. Beer, Donna Leung, Kamini Raghuram, Karen Lambie, James M. Piret, Connie J. Eaves, Suzan Imren, Yongjun Zhao, R K Humphries, Veronique Lecault
Publikováno v:
Leukemia
HOX genes have been implicated as regulators of normal and leukemic stem cell functionality, but the extent to which these activities are linked is poorly understood. Previous studies revealed that transduction of primitive mouse hematopoietic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8286c37305d72bb13b3cd08a1c0c3bcd
https://doi.org/10.1038/leu.2012.196
https://doi.org/10.1038/leu.2012.196
Autor:
Jürgen Krauter, Florian Kuchenbauer, R K Humphries, Tobias Berg, Grace Lin, Arnold Ganser, Michael Heuser, Courteney Lai, Gyeongsin Park, Malina Leung, Stephen Fung
Publikováno v:
Leukemia. 26:532-536
Abstract 4194 Cytogenetically normal acute myeloid leukemia (CN-AML) patients with high BAALC or MN1 expression have a poor prognosis. Whereas the oncogenic function of MN1 is well established, the functional role of BAALC in hematopoiesis is not kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21afc4a40ff4ebbe43aec86f8df17af
https://doi.org/10.1038/leu.2011.228
https://doi.org/10.1038/leu.2011.228
Autor:
E. Jervis, M. Marta Guarna, James G. Doheny, R. K. Humphries, Douglas G. Kilburn, R. A. J. Warren
Publikováno v:
Biochemical Journal. 339:429-434
A chimaera of stem cell factor (SCF) and a cellulose-binding domain from the xylanase Cex (CBDCex) effectively immobilizes SCF on a cellulose surface. The fusion protein retains both the cytokine properties of SCF and the cellulose-binding characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469619031ea11df98748b5cddb0e45e9
https://doi.org/10.1042/bj3390429
https://doi.org/10.1042/bj3390429
Autor:
R. K. Humphries, Lynn A. Raymond, Jamal Nasir, Martina Metzler, Michael R. Hayden, K. Nichol, Nansheng Chen, Rona K. Graham, C. D. Helgason, Krista McCutcheon
Publikováno v:
Journal of Neurochemistry. 72:1009-1018
Huntington disease (HD) is a neurodegenerative disorder associated with polyglutamine expansion in a recently identified protein, huntingtin. Huntingtin is widely expressed and plays a crucial role in development, because gene-targeted HD-/- mouse em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d69347f40ba9b04886bc6465a98858
https://doi.org/10.1046/j.1471-4159.1999.0721009.x
https://doi.org/10.1046/j.1471-4159.1999.0721009.x
Publikováno v:
Journal of Biological Chemistry. 271:27432-27437
Introduction of erythropoietin receptors (EpoRs) into the interleukin-3 (IL-3)-dependent murine hemopoietic cell line, Ba/F3, enables these cells to not only proliferate, after an initial lag in G1, but also to increase beta-globin mRNA levels in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38170e75a836cbfff270a38b3f908d7b
https://doi.org/10.1074/jbc.271.44.27432
https://doi.org/10.1074/jbc.271.44.27432