Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R. K. Flamm"'
Publikováno v:
B58. CLINICAL STUDIES IN LUNG INFECTIONS AND PNEUMONIA: TREATMENT AND OUTCOMES.
Publikováno v:
Antimicrobial agents and chemotherapy. 61(7)
Gepotidacin is a first-in-class, novel triazaacenaphthylene antibiotic that inhibits bacterial DNA replication and has in vitro activity against susceptible and drug-resistant pathogens. Reference in vitro methods were used to investigate the MICs an
Autor:
Dee Shortridge, R. E. Mendes, M Castanheira, Michael A. Pfaller, H.S. Sader, Leonard R. Duncan, R. K. Flamm
Publikováno v:
Journal of Infectious Diseases and Treatment.
Telavancin had MIC50, MIC90, and MIC100 values of 0.03, 0.06, and 0.12 μg/mL, respectively, against methicillinsusceptible (MSSA), methicillin-resistant (MRSA), and MRSA multidrug-resistant (MDR) subsets of Staphylococcus aureus. Isolates with eleva
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
The efficacy and safety of telavancin is under evaluation for the treatment of subjects with complicated Staphylococcus aureus bacteremia and S. aureus right-sided infective endocarditis. This study evaluated the telavancin activity against a global
Autor:
G, Griesgraber, M J, Kramer, R L, Elliott, A M, Nilius, P J, Ewing, P M, Raney, M H, Bui, R K, Flamm, D T, Chu, J J, Plattner, Y S, Or
Publikováno v:
Journal of Medicinal Chemistry. 41:1660-1670
A series of 3-descladinosyl-2,3-anhydro-6-O-methylerythromycin A 11, 12-cyclic carbazate analogues was prepared and evaluated for antibacterial activity. These 2,3-anhydro macrolides were found to be potent antibacterial agents in vitro against macro
Autor:
D.Y. Graham, D Shortridge, G. G. Stone, K Spakovsky, Rita Reddy, J Versalovic, M S Osato, Maria Pina Dore, R K Flamm, S. K. Tanaka
Publikováno v:
Journal of Antimicrobial Chemotherapy. 40:283-286
Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was si
Autor:
Joan Fung-Tomc, B Kolek, D P Bonner, R K Flamm, Beatrice Minassian, Elizabeth Gradelski, K Bush
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1010-1016
The in vitro activities of a new catechol-containing monobactam, BMS-180680 (SQ 84,100), were compared to those of aztreonam, ceftazidime, imipenem, piperacillin-tazobactam, ciprofloxacin, amikacin, and trimethoprim-sulfamethoxazole. BMS-180680 was o
Autor:
David Y. Graham, James Versalovic, K. Kibler, R. K. Flamm, S. K. Tanaka, M. V. Griffy, Mae F. Go, D. Shortridge, J. Beyer
Publikováno v:
Scopus-Elsevier
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions
Publikováno v:
Antimicrobial Agents and Chemotherapy. 35:2203-2208
An isolate of Serratia marcescens that produced both an inducible chromosomal and a plasmid-mediated TEM-1 beta-lactamase was resistant to ampicillin and amoxicillin and also demonstrated decreased susceptibility to extended-spectrum beta-lactam anti
Publikováno v:
Epidemiology and infection. 118(2)
A clinical trial was conducted in Argentina to determine the efficacy of clarithromycin plus lansoprazole for the treatment of Helicobacter pylori in duodenal ulcers and non-ulcer dyspepsia. PCR–RFLP was conducted on an 820-bp amplified product of