Zobrazeno 1 - 10
of 81
pro vyhledávání: '"R. K. Brojen Singh"'
Autor:
Md. Zubbair Malik, Mohammed Dashti, Yasmin Fatima, Arshad Channanath, Sumi Elsa John, R. K. Brojen Singh, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases. Robust rhythms of phosphoryla
Externí odkaz:
https://doaj.org/article/60860b2c51b848d7a37736d139fa6ab1
Identification of key regulators in Sarcoidosis through multidimensional systems biological approach
Autor:
Safia Tazyeen, Mohd Murshad Ahmed, Anam Farooqui, Aftab Alam, Md. Zubbair Malik, Mohd Saeed, Irfan Ahmad, Mohammed Abohashrh, R. K. Brojen Singh, Romana Ishrat
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Sarcoidosis is a multi-organ disorder where immunology, genetic and environmental factors play a key role in causing Sarcoidosis, but its molecular mechanism remains unclear. Identification of its genetics profiling that regulates the Sarcoi
Externí odkaz:
https://doaj.org/article/5e983d77f71c41af9952d67dba4f039c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct d
Externí odkaz:
https://doaj.org/article/8b1c7848d1d04c9482ce50d506332f2f
Autor:
Debasis Sahu, Subasa Chandra Bishwal, Md. Zubbair Malik, Sukanya Sahu, Sandeep Rai Kaushik, Shikha Sharma, Ekta Saini, Rakesh Arya, Archana Rastogi, Sandeep Sharma, Shanta Sen, R. K. Brojen Singh, Chuan-Ju Liu, Ranjan Kumar Nanda, Amulya Kumar Panda
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit the antiarthritic properties of TXR using an adjuvant-induced arthritic (AIA) rat model. AIA-induced rats showe
Externí odkaz:
https://doaj.org/article/049a1ce6644943798f359fdad5a16fbe
Autor:
Md. Zubbair Malik, Keilash Chirom, Shahnawaz Ali, Romana Ishrat, Pallavi Somvanshi, R. K. Brojen Singh
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Identification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the key regulators of this network and their importa
Externí odkaz:
https://doaj.org/article/22ef28d5349e412c8e07ea9c70c4de34
Autor:
Amit Kumar Lalwani, Kushagra Krishnan, Sali Abubaker Bagabir, Mustfa F. Alkhanani, Atiah H. Almalki, Shafiul Haque, Saurabh Kumar Sharma, R. K. Brojen Singh, Md. Zubbair Malik
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 451 (2022)
Dementia—a syndrome affecting human cognition—is a major public health concern given to its rising prevalence worldwide. Though multiple research studies have analyzed disorders such as Alzheimer’s disease and Frontotemporal dementia using a sy
Externí odkaz:
https://doaj.org/article/3dc0ba72e82045bcaa50b2966ac98c68
Autor:
Shahnawaz Ali, Md Zubbair Malik, Soibam Shyamchand Singh, Keilash Chirom, Romana Ishrat, R K Brojen Singh
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198525 (2018)
The breast cancer network constructed from 70 experimentally verified genes is found to follow hierarchical scale free nature with heterogeneous modular organization and diverge leading hubs. The topological parameters (degree distributions, clusteri
Externí odkaz:
https://doaj.org/article/c8cb382a1ce74789953e3a6b6d244f12
Publikováno v:
Nonlinear Dynamics. 105:797-811
Noise can drive the dynamics of stochastic systems to different important states. Delay is another significant parameter that may impart non-Markovian behavior in the system dynamics. The interplay of noise and delay can exhibit interesting, complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ab891b93eebd81e61d716b2a47be50
https://doi.org/10.1007/s11071-021-06643-5
https://doi.org/10.1007/s11071-021-06643-5
Autor:
Keilash Chirom, Md Zubbair Malik, Irengbam Rocky Mangangcha, Pallavi Somvanshi, R K Brojen Singh
Publikováno v:
Briefings in Bioinformatics. 23
Network medicine provides network theoretical tools, methods and properties to study underlying laws governing human interactome to identify disease states and disease complexity leading to drug discovery. Within this framework, we investigated the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5d3caff11d411bcd9cc4d19a4ed580
https://doi.org/10.1093/bib/bbac085
https://doi.org/10.1093/bib/bbac085
Autor:
Mohd Maksuf Ul Haque, Zubbair Malik, Nidhi Verma, R. K. Brojen Singh, Sheeraz Anwar, Saurabh Kumar Sharma
TAR-DNA-binding protein of 43 kDa (TDP-43) has been found in an unstable aggregated form in patients suffering from the inherited form of amyotrophic lateral sclerosis (ALS) and frontal temporal lobar degeneration and has also been associated with Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62fba507ceae39b96033b16f3145cba
https://doi.org/10.1016/b978-0-12-820066-7.00006-0
https://doi.org/10.1016/b978-0-12-820066-7.00006-0
