Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R. Justin Grams"'
Autor:
Jacob H. Murray, Ariel L. Burgio, Martina Beretta, Stefan R. Hargett, Thurl E. Harris, Ellen Olzomer, R. Justin Grams, Christopher J. Garcia, Catherine Li, Joseph M. Salamoun, Kyle L. Hoehn, Webster L. Santos
Publikováno v:
Journal of Medicinal Chemistry. 66:3876-3895
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::431ad6692206e016380422ebbca53dbe
https://doi.org/10.1021/acs.jmedchem.2c01573
https://doi.org/10.1021/acs.jmedchem.2c01573
Autor:
R. Justin Grams, Ku-Lung Hsu
Publikováno v:
Trends Pharmacol Sci
Bioactive small molecules that form covalent bonds with a target protein are important tools for basic research and can be highly effective drugs. This review highlights reactive groups found in a collection of thiophilic and oxophilic drugs that med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d307a96735af1d1ae56d751eb8c8b62
https://doi.org/10.1016/j.tips.2021.12.002
https://doi.org/10.1016/j.tips.2021.12.002
Autor:
Monsurat M. Lawal, Valerie Vaissier Welborn, Carla Slebodnick, Connor Szwetkowski, Daniel Foster, Webster L. Santos, Carol Ann Rosenblum, R. Justin Grams
Publikováno v:
Advanced Synthesis & Catalysis. 364:172-178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b69ccd6b872dc9d12a67bc57a0b88f7
https://doi.org/10.1002/adsc.202101020
https://doi.org/10.1002/adsc.202101020
Autor:
R Justin, Grams, Ku-Lung, Hsu
Publikováno v:
Nature chemical biology. 18(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e26774623288a34dfac6f590ea0c9f2b
https://pubmed.ncbi.nlm.nih.gov/35710618
https://pubmed.ncbi.nlm.nih.gov/35710618
Akademický článek
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Publikováno v:
Organic Letters. 21:6795-6799
A base-mediated trans-hydroboration of propiolamides that provides access to previously elusive primary and secondary (E)-β-borylacrylamide products has been developed. In the presence of n-butyllithium and pinacolborane, complete regioselectivity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf5612ac46a94a770ba8c5515d499f4d
https://doi.org/10.1021/acs.orglett.9b02408
https://doi.org/10.1021/acs.orglett.9b02408
Publikováno v:
Tetrahedron. 75:2113-2117
A method for the semi-reduction of alkynoic acids through an α-borylation and subsequent protodeborylation mechanism has been developed. The transition metal-free protocol is achieved through the activation of bis(pinacolato)diboron by an in situ ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14dffc5fd619fe66971881ab0db8f9a
https://doi.org/10.1016/j.tet.2019.02.030
https://doi.org/10.1016/j.tet.2019.02.030
Publikováno v:
Organic letters. 22(17)
We report a transition-metal-free trans-selective semireduction of alkynes with pinacolborane and catalytic potassium tert-butoxide. A variety of 3-substituted primary and secondary propiolamides, including an analog of FK866, a potent nicotinamide m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50763fd7cf6df99c13f0a0a76da7ccee
https://pubmed.ncbi.nlm.nih.gov/32846095
https://pubmed.ncbi.nlm.nih.gov/32846095