Zobrazeno 1 - 10
of 26
pro vyhledávání: '"R. John Lye"'
Autor:
Lingdan Chen, Charles R. Farber, R. John Lye, Brian H. Annex, Ayotunde O. Dokun, Mitsuharu Okutsu, Douglas A. Marchuk, Damian M. Craig, Surovi Hazarika, Svati H. Shah, W. Schuyler Jones
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 309:H790-H803
In prior studies from multiple groups, outcomes following experimental peripheral arterial disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with PAD, disease outcomes differ, even when there are similarities in ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735e5a9ba1f7137e119f0c3b9bf1c6e6
https://doi.org/10.1152/ajpheart.00803.2014
https://doi.org/10.1152/ajpheart.00803.2014
Autor:
R. John Lye, Warren J. Leonard, Ayotunde O. Dokun, Alexis Cunningham, Kevin Houston, Tao Wang, Brian H. Annex, Rosanne Spolski, Lingdan Chen, Surovi Hazarika
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1218-1225
Objective— Surgical hindlimb ischemia (HLI) in mice has become a valuable preclinical model to study peripheral arterial disease. We previously identified that the different phenotypic outcomes after HLI across inbred mouse strains is related to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fdac5fd6c6668fcd1e4fa0a7a25b1a
https://doi.org/10.1161/atvbaha.115.305476
https://doi.org/10.1161/atvbaha.115.305476
Autor:
Tao Wang, Surovi Hazarika, Achillieas N. Pitsillides, Brian H. Annex, Charles R. Farber, R. John Lye, Ayotunde O. Dokun
Publikováno v:
Circulation. 127:1818-1828
Background— MicroRNAs are key regulators of gene expression in response to injury, but there is limited knowledge of their role in ischemia-induced angiogenesis, such as in peripheral arterial disease. Here, we used an unbiased strategy and took ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab5c7a64865984c35d352871b5ea10
https://doi.org/10.1161/circulationaha.112.000860
https://doi.org/10.1161/circulationaha.112.000860
Autor:
Sean S Li, Arabindra B. Katwal, Brent A. French, R. John Lye, Bryan A. Piras, Elisa A. Ferrante, Surovi Hazarika, Zhen Yan, Prasad Konkalmatt, Brian H. Annex, John M. Sanders
Publikováno v:
Gene therapy
Targeting therapeutic gene expression to the skeletal muscle following intravenous (IV) administration is an attractive strategy for treating peripheral arterial disease (PAD), except that vector access to the ischemic limb could be a limiting factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c794c6b45cdb8f39920664b3096ee0
https://doi.org/10.1038/gt.2013.16
https://doi.org/10.1038/gt.2013.16
Autor:
R. John Lye, John M. Sanders, Brian H. Annex, Amina Saqib, Konkal Matt R. Prasad, Brent A. French, Arabindra B. Katwal
Publikováno v:
Journal of Vascular Surgery. 54:810-818
ObjectiveNeovascularization is a physiologic repair process that partly depends on nitric oxide. Extracellular superoxide dismutase (EcSOD) is the major scavenger of superoxide. It is an important regulator of nitric oxide bioavailability and thus pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d27694b173405484406e6c730973ec
https://doi.org/10.1016/j.jvs.2011.03.278
https://doi.org/10.1016/j.jvs.2011.03.278
Publikováno v:
Biology of Reproduction. 83:807-817
A fully developed, functional epididymis is important for male fertility. In particular, it is apparent that without the most proximal region, the initial segment (IS), infertility results. Therefore, it is important to understand the development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595aec4b3e847b5c3cf8faed51efcab6
https://doi.org/10.1095/biolreprod.110.085613
https://doi.org/10.1095/biolreprod.110.085613
Autor:
Warren J. Leonard, Kevin Houston, Tao Wang, Rosanne Spolski, Aditya Sharma, R. John Lye, Brian H. Annex, Alexis Cunningham, Ayotunde O. Dokun, Lingdan Chen
Publikováno v:
Vascular medicine (London, England). 21(2)
In most patients with symptomatic peripheral artery disease (PAD), severe stenosis in or occlusion of the major blood vessels that supply the legs make the amount of distal blood flow dependent on the capacity to induce angiogenesis and collateral ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1113847e7f731b81ced5f8098c7f127
https://pubmed.ncbi.nlm.nih.gov/26705256
https://pubmed.ncbi.nlm.nih.gov/26705256
Publikováno v:
Circulation. 132
Introduction: Ischemic skeletal muscle is preferentially targeted after IV injection of AAV9 in mouse models of hind-limb ischemia (HLI). Ischemia is known to induce desialylation of cell surface glycans, unmasking the cellular receptor for AAV9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcde4585a74b5ffcbcb319fdd503e3a9
https://doi.org/10.1161/circ.132.suppl_3.17327
https://doi.org/10.1161/circ.132.suppl_3.17327
Autor:
Gail A. Cornwall, Barry T. Hinton, Jacquelyn C. Labus, Ling Yang, Nelson Hsia, R. John Lye, Richard N. Day, Jennifer L. Kirby
Publikováno v:
Biology of Reproduction. 71:613-619
The mammalian epididymis plays a critical role in sperm maturation, a function dependent on testicular androgens. However, the function of the initial segment, the most proximal part of the epididymis, is also dependent on luminal factors of testicul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d7af405f465dcd45e009f2940348777
https://doi.org/10.1095/biolreprod.103.025635
https://doi.org/10.1095/biolreprod.103.025635
Publikováno v:
Molecular and Cellular Endocrinology. 216:75-82
In addition to the scientific issues associated with male contraception, there are a variety of other concerns that must be addressed before new male contraceptives reach the market. Cultural attitudes toward contraception will play a role both in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8d7c7ce423a309ae7b2fe127e989fb
https://doi.org/10.1016/j.mce.2003.10.071
https://doi.org/10.1016/j.mce.2003.10.071