Zobrazeno 1 - 10 of 582 pro vyhledávání: '"R. Jefferis"'
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Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma receptor I and influence the synthesis of its oligosaccharide chains
Autor: J Lund, N Takahashi, J D Pound, M Goodall, R Jefferis
Publikováno v: The Journal of Immunology. 157:4963-4969
Glycosylation at Asn297 within the CH2 domains of IgG is important for recognition by the effector ligands Fc gammaR and C. Protein engineering has been used to replace amino acid residues within the extensive oligosaccharide interaction site that co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c4b2e0fd62be1c6b193e8f1c702abc1
https://doi.org/10.4049/jimmunol.157.11.4963
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Anti-CD40 plus interleukin-4-activated human naive B cell lines express unmutated immunoglobulin genes with intraclonal heavy chain isotype variability
Autor: J van Dooren, Serge Lebecque, Françoise Rousset, Isabelle Durand, L Galibert, Jacques Banchereau, R Jefferis
Publikováno v: European Journal of Immunology. 25:733-737
Combination of anti-CD40 antibody and interleukin-4 (IL-4) induces B cell clonal expansion reminiscent of the T-dependent proliferation following antigenic challenge in vivo. We have analyzed the usage of CH genes and the presence or absence of somat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836cc55ebc6dc7be41cb74fadfd1d5dc
https://doi.org/10.1002/eji.1830250316
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6
A novel 13C isotopic labelling strategy for probing the structure and dynamics of glycan chains in situ on glycoproteins
Autor: A.M. Gilhespy-Muskett, S.W. Homans, R. Jefferis, J. Partridge
Publikováno v: Glycobiology. 4:485-489
A protocol is described for uniform 13C labelling of terminal galactose residues of the glycan chains of glycoproteins, using an enzymatic method which does not perturb the protein. The technique is illustrated by application to the biantennary N-lin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d194c729222f546173da0a715a98b94a
https://doi.org/10.1093/glycob/4.4.485
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7
Evaluation of monoclonal antibodies having specificity for human IgG subclasses: results of the 2nd IUIS/WHO collaborative study
Autor: R. Jefferis, C.B. Reimer, F. Skvaril, G.G. de Lange, D.M. Goodall, T.L. Bentley, D.J. Phillips, A. Vlug, S. Harada, J. Radl, E. Claassen, J.A. Boersma, J. Coolen
Publikováno v: Immunology Letters. 31:143-168
Following the 1st IUIS/WHO Collaborative Study of monoclonal anti-IgG subclass antibodies, a panel of WHO Specificity Reference Reagents (SRR) was established [Jefferis, R., et al. (1985) Immunol. Lett., 10, 223]. At the time, the hope was expressed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38619118734a42bd4c67cda2d5eae55
https://doi.org/10.1016/0165-2478(92)90141-a
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Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG
Autor: J Lund, G Winter, P T Jones, J D Pound, T Tanaka, M R Walker, P J Artymiuk, Y Arata, D R Burton, R Jefferis, J M Woof
Publikováno v: The Journal of Immunology. 147:2657-2662
Cellular receptors for IgG (Fc gamma R) mediate important protective functions. By using site-specific mutants of a chimeric antibody (mouse V H domain and L chain; human IgG3 C H domains), we have demonstrated that human Fc gamma RI interacts with a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9e97acd952e58db52c698868d8a7b98
https://doi.org/10.4049/jimmunol.147.8.2657
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